Bulletin of Experimental Biology and Medicine, volume 161, issue 2, pages 308-311
Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium
E A Safonova
1
,
K A Lopatina
1
,
A V Vychuzhanina
1
,
L A Ermolaeva
1
,
T G Razina
1
,
E P Zueva
1
Publication type: Journal Article
Publication date: 2016-06-01
scimago Q3
wos Q4
SJR: 0.245
CiteScore: 1.5
Impact factor: 0.9
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
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