Springer Nature
Bulletin of Experimental Biology and Medicine
,  volume 161 ,  issue 5 ,  pages 683-686

Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue

T G Borovskaya 1
, 
A M Dygai 1
, 
Yu A Shchemerova 1
, 
S I Kamalova 1
, 
V A Mashanova 1
, 
A V Vychuzhanina 1
, 
M E Poluektova 1
, 
P G Madonov 1
, 
D N Kinsht 1
, 
V E Goldberg 2
1
 
E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia | 
2
 
Publication type: Journal Article
Publication date: 2016-09-01
Springer Nature
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
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Borovskaya T. G. et al. Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue // Bulletin of Experimental Biology and Medicine. 2016. Vol. 161. No. 5. pp. 683-686.
GOST all authors (up to 50) Copy
Borovskaya T. G., Dygai A. M., Shchemerova Yu. A., Kamalova S. I., Mashanova V. A., Vychuzhanina A. V., Poluektova M. E., Madonov P. G., Kinsht D. N., Goldberg V. E. Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue // Bulletin of Experimental Biology and Medicine. 2016. Vol. 161. No. 5. pp. 683-686.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s10517-016-3485-0
UR - https://doi.org/10.1007/s10517-016-3485-0
TI - Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue
T2 - Bulletin of Experimental Biology and Medicine
AU - Borovskaya, T G
AU - Dygai, A M
AU - Shchemerova, Yu A
AU - Kamalova, S I
AU - Mashanova, V A
AU - Vychuzhanina, A V
AU - Poluektova, M E
AU - Madonov, P G
AU - Kinsht, D N
AU - Goldberg, V E
PY - 2016
DA - 2016/09/01
PB - Springer Nature
SP - 683-686
IS - 5
VL - 161
PMID - 27709383
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2016_Borovskaya,
author = {T G Borovskaya and A M Dygai and Yu A Shchemerova and S I Kamalova and V A Mashanova and A V Vychuzhanina and M E Poluektova and P G Madonov and D N Kinsht and V E Goldberg},
title = {Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2016},
volume = {161},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s10517-016-3485-0},
number = {5},
pages = {683--686},
doi = {10.1007/s10517-016-3485-0}
}
MLA
Cite this
MLA Copy
Borovskaya, T. G., et al. “Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue.” Bulletin of Experimental Biology and Medicine, vol. 161, no. 5, Sep. 2016, pp. 683-686. https://doi.org/10.1007/s10517-016-3485-0.