Bulletin of Experimental Biology and Medicine, volume 161, issue 5, pages 683-686
Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue
T G Borovskaya
1
,
A M Dygai
1
,
Yu A Shchemerova
1
,
S I Kamalova
1
,
V A Mashanova
1
,
A V Vychuzhanina
1
,
M E Poluektova
1
,
P G Madonov
1
,
D N Kinsht
1
,
V E Goldberg
2
1
E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia
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Publication type: Journal Article
Publication date: 2016-09-01
scimago Q3
wos Q4
SJR: 0.245
CiteScore: 1.5
Impact factor: 0.9
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
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