Cellular and Molecular Neurobiology, volume 36, issue 6, pages 839-849
Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent
Peregud Danil I
1, 2
,
Yakovlev Alexander A
2
,
Stepanichev Mikhail Yu.
2
,
Onufriev Mikhail V.
2
,
Panchenko Leonid F
1, 3
,
Publication type: Journal Article
Publication date: 2015-09-07
Journal:
Cellular and Molecular Neurobiology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4
ISSN: 02724340, 15736830
General Medicine
Cell Biology
Cellular and Molecular Neuroscience
Abstract
Nitric oxide (NO) mediates pharmacological effects of opiates including dependence and abstinence. Modulation of NO synthesis during the induction phase of morphine dependence affects manifestations of morphine withdrawal syndrome, though little is known about mechanisms underlying this phenomenon. Neurotrophic and growth factors are involved in neuronal adaptation during opiate dependence. NO-dependent modulation of morphine dependence may be mediated by changes in expression and activity of neurotrophic and/or growth factors in the brain. Here, we studied the effects of NO synthesis inhibition during the induction phase of morphine dependence on the expression of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and insulin-like growth factor 1 (IGF1) as well as their receptors in rat brain regions after spontaneous morphine withdrawal in dependent animals. Morphine dependence in rats was induced within 6 days by 12 injections of morphine in increasing doses (10–100 mg/kg), and NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME) (10 mg/kg) was given 1 h before each morphine injection. The expression of the BDNF, GDNF, NGF, IGF1, and their receptors in the frontal cortex, striatum, hippocampus, and midbrain was assessed 40 h after morphine withdrawal. L-NAME treatment during morphine intoxication resulted in an aggravation of the spontaneous morphine withdrawal severity. Morphine withdrawal was accompanied by upregulation of BDNF, IGF1, and their receptors TrkB and IGF1R, respectively, on the mRNA level in the frontal cortex, and only BDNF in hippocampus and midbrain. L-NAME administration during morphine intoxication decreased abstinence-induced upregulation of these mRNAs in the frontal cortex, hippocampus and midbrain. L-NAME prevented from abstinence-induced elevation of mature but not pro-form of BDNF polypeptide in the frontal cortex. While morphine abstinence did not affect TrkB protein levels as well as its phosphorylation status, inhibition of NO synthesis decreased levels of phosphorylated TrkB after withdrawal. Thus, NO signaling during induction of dependence may be involved in the mechanisms of BDNF expression and processing at abstinence, thereby affecting signaling through TrkB in the frontal cortex.
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Peregud D. I. et al. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent // Cellular and Molecular Neurobiology. 2015. Vol. 36. No. 6. pp. 839-849.
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Peregud D. I., Yakovlev A. A., Stepanichev M. Y., Onufriev M. V., Panchenko L. F., Gulyaeva N. V. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent // Cellular and Molecular Neurobiology. 2015. Vol. 36. No. 6. pp. 839-849.
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TY - JOUR
DO - 10.1007/s10571-015-0267-6
UR - https://doi.org/10.1007%2Fs10571-015-0267-6
TI - Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent
T2 - Cellular and Molecular Neurobiology
AU - Peregud, Danil I
AU - Yakovlev, Alexander A
AU - Stepanichev, Mikhail Yu.
AU - Onufriev, Mikhail V.
AU - Panchenko, Leonid F
AU - Gulyaeva, Natalia V
PY - 2015
DA - 2015/09/07 00:00:00
PB - Springer Nature
SP - 839-849
IS - 6
VL - 36
SN - 0272-4340
SN - 1573-6830
ER -
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@article{2015_Peregud,
author = {Danil I Peregud and Alexander A Yakovlev and Mikhail Yu. Stepanichev and Mikhail V. Onufriev and Leonid F Panchenko and Natalia V Gulyaeva},
title = {Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent},
journal = {Cellular and Molecular Neurobiology},
year = {2015},
volume = {36},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007%2Fs10571-015-0267-6},
number = {6},
pages = {839--849},
doi = {10.1007/s10571-015-0267-6}
}
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Peregud, Danil I., et al. “Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent.” Cellular and Molecular Neurobiology, vol. 36, no. 6, Sep. 2015, pp. 839-849. https://doi.org/10.1007%2Fs10571-015-0267-6.
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