Cellular and Molecular Neurobiology, volume 39, issue 6, pages 729-750

The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia

Gruzdev S K ¹

Yakovlev A. A. ^{2, 3}

Druzhkova T A ³

Guekht A. B. ^{3, 4}

Gulyaeva N. V. ^{2, 3}

Hide authors affiliations Show authors affiliations: 4 affiliations

Institute of Medicine, RUDN University, Moscow, Russia |

Institute of Higher nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |

Moscow Research & Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russia |

⁴

Russian National Research Medical University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2019-05-14

Springer Nature

Journal: Cellular and Molecular Neurobiology

Quartile SCImago

Quartile WOS

Impact factor: 4

ISSN: 02724340, 15736830

DOI: 10.1007/s10571-019-00684-6

Copy DOI

General Medicine

Cell Biology

Cellular and Molecular Neuroscience

Abstract

MicroRNAs (miRNAs) only recently have been recognized as promising molecules for both fundamental and clinical neuroscience. We provide a literature review of miRNA biomarker studies in three most prominent psychiatric disorders (depression, bipolar disorder and schizophrenia) with the particular focus on depression due to its social and healthcare importance. Our search resulted in 191 unique miRNAs across 35 human studies measuring miRNA levels in blood, serum or plasma. 30 miRNAs replicated in more than one study. Most miRNAs targeted neuroplasticity and neurodevelopment pathways. Various limitations do not allow us to make firm conclusions on clinical potential of studied miRNAs. Based on our results we discuss the rationale for future research investigations of exosomal mechanisms to overcome methodological caveats both in studying etiology and pathogenesis, and providing an objective back-up for clinical decisions.

By date By citations

Citations by journals

	1 2 3 4 5
Neurochemical Journal	Neurochemical Journal, 5, 10.87% Neurochemical Journal 5 publications, 10.87%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 8.7% International Journal of Molecular Sciences 4 publications, 8.7%
Journal of Translational Medicine	Journal of Translational Medicine, 2, 4.35% Journal of Translational Medicine 2 publications, 4.35%
Journal of Affective Disorders	Journal of Affective Disorders, 2, 4.35% Journal of Affective Disorders 2 publications, 4.35%
Bioengineered	Bioengineered, 2, 4.35% Bioengineered 2 publications, 4.35%
Journal of Biomaterials and Tissue Engineering	Journal of Biomaterials and Tissue Engineering, 1, 2.17% Journal of Biomaterials and Tissue Engineering 1 publication, 2.17%
Current Drug Targets	Current Drug Targets, 1, 2.17% Current Drug Targets 1 publication, 2.17%
Epigenomics	Epigenomics, 1, 2.17% Epigenomics 1 publication, 2.17%
Aging	Aging, 1, 2.17% Aging 1 publication, 2.17%
Schizophrenia	Schizophrenia, 1, 2.17% Schizophrenia 1 publication, 2.17%
Non-coding RNA	Non-coding RNA, 1, 2.17% Non-coding RNA 1 publication, 2.17%
Cells	Cells, 1, 2.17% Cells 1 publication, 2.17%
Genes	Genes, 1, 2.17% Genes 1 publication, 2.17%
Frontiers in Psychiatry	Frontiers in Psychiatry, 1, 2.17% Frontiers in Psychiatry 1 publication, 2.17%
Frontiers in Molecular Neuroscience	Frontiers in Molecular Neuroscience, 1, 2.17% Frontiers in Molecular Neuroscience 1 publication, 2.17%
Clinical and Translational Imaging	Clinical and Translational Imaging, 1, 2.17% Clinical and Translational Imaging 1 publication, 2.17%
Journal of Biomedical Science	Journal of Biomedical Science, 1, 2.17% Journal of Biomedical Science 1 publication, 2.17%
Translational Psychiatry	Translational Psychiatry, 1, 2.17% Translational Psychiatry 1 publication, 2.17%
European Archives of Psychiatry and Clinical Neuroscience	European Archives of Psychiatry and Clinical Neuroscience, 1, 2.17% European Archives of Psychiatry and Clinical Neuroscience 1 publication, 2.17%
Molecular Neurobiology	Molecular Neurobiology, 1, 2.17% Molecular Neurobiology 1 publication, 2.17%
Scientific Reports	Scientific Reports, 1, 2.17% Scientific Reports 1 publication, 2.17%
Neuropharmacology	Neuropharmacology, 1, 2.17% Neuropharmacology 1 publication, 2.17%
Progress in Neuro-Psychopharmacology and Biological Psychiatry	Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1, 2.17% Progress in Neuro-Psychopharmacology and Biological Psychiatry 1 publication, 2.17%
Journal of Psychiatric Research	Journal of Psychiatric Research, 1, 2.17% Journal of Psychiatric Research 1 publication, 2.17%
Molecular Biology	Molecular Biology, 1, 2.17% Molecular Biology 1 publication, 2.17%
World Journal of Biological Psychiatry	World Journal of Biological Psychiatry, 1, 2.17% World Journal of Biological Psychiatry 1 publication, 2.17%
IEEE Journal of Biomedical and Health Informatics	IEEE Journal of Biomedical and Health Informatics, 1, 2.17% IEEE Journal of Biomedical and Health Informatics 1 publication, 2.17%
IEEE Transactions on Nanobioscience	IEEE Transactions on Nanobioscience, 1, 2.17% IEEE Transactions on Nanobioscience 1 publication, 2.17%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 2.17% Frontiers in Molecular Biosciences 1 publication, 2.17%

	1 2 3 4 5

Citations by publishers

	1 2 3 4 5 6 7 8 9
Springer Nature	Springer Nature, 9, 19.57% Springer Nature 9 publications, 19.57%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 8, 17.39% Multidisciplinary Digital Publishing Institute (MDPI) 8 publications, 17.39%
Elsevier	Elsevier, 7, 15.22% Elsevier 7 publications, 15.22%
Pleiades Publishing	Pleiades Publishing, 6, 13.04% Pleiades Publishing 6 publications, 13.04%
Frontiers Media S.A.	Frontiers Media S.A., 3, 6.52% Frontiers Media S.A. 3 publications, 6.52%
Taylor & Francis	Taylor & Francis, 3, 6.52% Taylor & Francis 3 publications, 6.52%
IEEE	IEEE, 2, 4.35% IEEE 2 publications, 4.35%
American Scientific Publishers	American Scientific Publishers, 1, 2.17% American Scientific Publishers 1 publication, 2.17%
Bentham Science	Bentham Science, 1, 2.17% Bentham Science 1 publication, 2.17%
Future Medicine	Future Medicine, 1, 2.17% Future Medicine 1 publication, 2.17%
Impact Journals	Impact Journals, 1, 2.17% Impact Journals 1 publication, 2.17%
Cambridge University Press	Cambridge University Press, 1, 2.17% Cambridge University Press 1 publication, 2.17%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 2.17% American Chemical Society (ACS) 1 publication, 2.17%
	1 2 3 4 5 6 7 8 9

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0],"codes":[0,0,0,0,0,0],"imageUrls":["","","","","",""],"datasets":[{"label":"Citations number","data":[1,10,12,9,12,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["2.17","21.74","26.09","19.57","26.09","4.35"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Neurochemical Journal","International Journal of Molecular Sciences","Journal of Translational Medicine","Journal of Affective Disorders","Bioengineered","Journal of Biomaterials and Tissue Engineering","Current Drug Targets","Epigenomics","Aging","Schizophrenia","Non-coding RNA","Cells","Genes","Frontiers in Psychiatry","Frontiers in Molecular Neuroscience","Clinical and Translational Imaging","Journal of Biomedical Science","Translational Psychiatry","European Archives of Psychiatry and Clinical Neuroscience","Molecular Neurobiology","Scientific Reports","Neuropharmacology","Progress in Neuro-Psychopharmacology and Biological Psychiatry","Journal of Psychiatric Research","Molecular Biology","World Journal of Biological Psychiatry","IEEE Journal of Biomedical and Health Informatics","IEEE Transactions on Nanobioscience","Frontiers in Molecular Biosciences"],"ids":[25515,14627,18128,20079,22749,26589,8184,12707,780,28882,18908,25293,8879,5797,20786,7661,24316,15662,10540,24041,13767,21388,11814,20442,1134,18705,15676,2376,3133],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp"],"datasets":[{"label":"","data":[5,4,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[10.87,8.7,4.35,4.35,4.35,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17,2.17],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier","Pleiades Publishing","Frontiers Media S.A.","Taylor & Francis","IEEE","American Scientific Publishers","Bentham Science","Future Medicine","Impact Journals","Cambridge University Press","American Chemical Society (ACS)"],"ids":[8,202,17,101,208,18,6953,679,39,6949,342,1,40],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/cF81zWlLdkmYekymGuDcSdvgBGNKaIDoMoeJtHS1_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[9,8,7,6,3,3,2,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[19.57,17.39,15.22,13.04,6.52,6.52,4.35,2.17,2.17,2.17,2.17,2.17,2.17],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

Gruzdev S. K. et al. The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia // Cellular and Molecular Neurobiology. 2019. Vol. 39. No. 6. pp. 729-750.

GOST all authors (up to 50) Copy

Gruzdev S. K., Yakovlev A. A., Druzhkova T. A., Guekht A. B., Gulyaeva N. V. The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia // Cellular and Molecular Neurobiology. 2019. Vol. 39. No. 6. pp. 729-750.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1007/s10571-019-00684-6

UR - https://doi.org/10.1007%2Fs10571-019-00684-6

TI - The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia

T2 - Cellular and Molecular Neurobiology

AU - Gruzdev, S K

AU - Yakovlev, A. A.

AU - Druzhkova, T A

AU - Guekht, A. B.

AU - Gulyaeva, N. V.

PY - 2019

DA - 2019/05/14 00:00:00

PB - Springer Nature

SP - 729-750

IS - 6

VL - 39

SN - 0272-4340

SN - 1573-6830

ER -

BibTex |

Cite this

BibTex Copy

@article{2019_Gruzdev,

author = {S K Gruzdev and A. A. Yakovlev and T A Druzhkova and A. B. Guekht and N. V. Gulyaeva},

title = {The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia},

journal = {Cellular and Molecular Neurobiology},

year = {2019},

volume = {39},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1007%2Fs10571-019-00684-6},

number = {6},

pages = {729--750},

doi = {10.1007/s10571-019-00684-6}

}

MLA

Cite this

MLA Copy

Gruzdev, S. K., et al. “The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia.” Cellular and Molecular Neurobiology, vol. 39, no. 6, May. 2019, pp. 729-750. https://doi.org/10.1007%2Fs10571-019-00684-6.

Found error?

Publisher

Springer Nature

Journal

Cellular and Molecular Neurobiology

Quartile SCImago

Quartile WOS

Impact factor

ISSN

02724340 (Print)
15736830 (Electronic)

Labs

Laboratory of Functional Biochemistry of the Nervous System

Profiles