Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts
Vadim S. Pokrovsky
1, 2
,
N Yu Anisimova
1
,
D Zh Davydov
1
,
S V Bazhenov
3, 4
,
N V Bulushova
3
,
G B Zavilgelsky
3
,
V Y Kotova
3
,
I. V. Manukhov
3, 4
Publication type: Journal Article
Publication date: 2018-06-15
scimago Q1
wos Q2
SJR: 1.074
CiteScore: 6.9
Impact factor: 2.7
ISSN: 01676997, 15730646
PubMed ID:
29948359
Oncology
Pharmacology
Pharmacology (medical)
Abstract
The anti-cancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer models in vitro and in vivo. The calculated EC50 values for MGL were 4.4 U/ml for A549, 7.5 U/ml for SK-BR3, 2.4 U/ml for SKOV3, and 0.4 U/ml for MCF7 cells. The combination of doxorubicin (DOX) and MGL was more effective for A549 human lung cancer growth inhibition than either agent alone in vitro and in vivo. MGL reduced the EC50 of doxorubicin from 35.9 μg/mL to 0.01–0.265 μg/mL. The growth inhibitory effect of DOX + MGL on A549 xenografts in vivo was reflective of the results obtained in vitro. The inhibition rate of tumor growth in the combined arm was 57%, significantly higher than that in the doxorubicin (p = 0.033)-alone arm.
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GOST
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Pokrovsky V. S. et al. Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts // Investigational New Drugs. 2018. Vol. 37. No. 2. pp. 201-209.
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Pokrovsky V. S., Yu Anisimova N., Zh Davydov D., Bazhenov S. V., Bulushova N. V., Zavilgelsky G. B., Kotova V. Y., Manukhov I. V. Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts // Investigational New Drugs. 2018. Vol. 37. No. 2. pp. 201-209.
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RIS
Copy
TY - JOUR
DO - 10.1007/s10637-018-0619-4
UR - https://link.springer.com/10.1007/s10637-018-0619-4
TI - Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts
T2 - Investigational New Drugs
AU - Pokrovsky, Vadim S.
AU - Yu Anisimova, N
AU - Zh Davydov, D
AU - Bazhenov, S V
AU - Bulushova, N V
AU - Zavilgelsky, G B
AU - Kotova, V Y
AU - Manukhov, I. V.
PY - 2018
DA - 2018/06/15
PB - Springer Nature
SP - 201-209
IS - 2
VL - 37
PMID - 29948359
SN - 0167-6997
SN - 1573-0646
ER -
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BibTex (up to 50 authors)
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@article{2018_Pokrovsky,
author = {Vadim S. Pokrovsky and N Yu Anisimova and D Zh Davydov and S V Bazhenov and N V Bulushova and G B Zavilgelsky and V Y Kotova and I. V. Manukhov},
title = {Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts},
journal = {Investigational New Drugs},
year = {2018},
volume = {37},
publisher = {Springer Nature},
month = {jun},
url = {https://link.springer.com/10.1007/s10637-018-0619-4},
number = {2},
pages = {201--209},
doi = {10.1007/s10637-018-0619-4}
}
Cite this
MLA
Copy
Pokrovsky, Vadim S., et al. “Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.” Investigational New Drugs, vol. 37, no. 2, Jun. 2018, pp. 201-209. https://link.springer.com/10.1007/s10637-018-0619-4.