Laboratory of Biochemical Fundamentals of Pharmacology and Tumor Models

The main direction of scientific research in the laboratory is the study of new agents with antitumor activity and models for evaluating the antitumor effect. To carry out research, in addition to standard equipment, the laboratory has specially equipped facilities for breeding and keeping immunodeficient animals, as well as a Bank of tumor materials (cell cultures and strains of transplanted animal tumors) and a Collection of human tumor strains

The laboratory conducts research on the mechanisms of action and specific antitumor activity of new antitumor agents and tumor treatment methods on tumor growth models, including human tumor xenographs in immunodeficient Balb/c nude mice and Danio rerio embryos of its own breeding.

In 2018-2021, research in the laboratory was supported by grants:

• RNF project No. 18-75-10008: "Study of changes in the profile of steroid hormones and the mechanism of antitumor action of new steroid inhibitors of SUR17A1 and their metabolites for individualization of prostate cancer therapy" Project completion period is 2018-2021.
• Grant of the President of the Russian Federation MD-1780.2017.7, on the topic "Studying the effectiveness of L-methionine gamma lyase in human tumor models in vivo under the control of markers of apoptosis and cell proliferation". The deadline for completing the work on the grant is 2017-2018.