Metabolic Brain Disease, volume 32, issue 2, pages 577-583

Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder

Pochigaeva Ksenia ¹

Druzhkova Tatiana ¹

Yakovlev Alexander ^{1, 2}

Onufriev Mikhail ^{1, 2}

Grishkina Maria ¹

Chepelev Aleksey ¹

Guekht Alla ^{1, 3}

Gulyaeva Natalia ^{1, 2}

Hide authors affiliations Show authors affiliations: 3 affiliations

Healthcare Department of Moscow, Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia |

Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |

Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2017-01-07

Springer Nature

Journal: Metabolic Brain Disease

Quartile SCImago

Quartile WOS

Impact factor: 3.6

ISSN: 08857490, 15737365

DOI: 10.1007/s11011-017-9952-0

Copy DOI

Biochemistry

Cellular and Molecular Neuroscience

Neurology (clinical)

Abstract

Hair cortisol is regarded as a promising marker of hypothalamic-pituitary-adrenal axis (HPAA) activity alterations due to stress, somatic and mental health conditions. Hair cortisol was previously reported to be elevated in patients with depression, however the data related to remission and recurrent depressive episodes are different. In this study, levels of hair cortisol were assessed in female patients with major depressive disorder (MDD) and the validity of hair cortisol as a marker of HPAA activity in this condition was evaluated. Hair cortisol was measured in 1 cm hair segments of 21 female patients with MDD and 22 female age-matched controls using enzyme-immunoassay analysis. Concurrently, serum cortisol was assessed and psychological status was evaluated using 17-item Hamilton Depression Rating Scale (HAMD-17), Beck Depression Inventory (BDI) and the Spielberger state trait anxiety inventory (STAI). The levels of hair cortisol were significantly lower in the MDD group, while serum cortisol levels were significantly higher in patients, as compared with controls. A significant negative correlation was found between HAMD-17 scores and hair cortisol. Decreased hair cortisol found in female patients with MDD as compared to controls suggests downregulation of HPAA activity during the preceding month. Further studies are needed to investigate the profiles of hair cortisol at different stages of depressive disorder to establish this parameter as a handy clinical tool.

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Pochigaeva K. et al. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder // Metabolic Brain Disease. 2017. Vol. 32. No. 2. pp. 577-583.

GOST all authors (up to 50) Copy

Pochigaeva K., Druzhkova T., Yakovlev A., Onufriev M., Grishkina M., Chepelev A., Guekht A., Gulyaeva N. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder // Metabolic Brain Disease. 2017. Vol. 32. No. 2. pp. 577-583.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s11011-017-9952-0

UR - https://doi.org/10.1007%2Fs11011-017-9952-0

TI - Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder

T2 - Metabolic Brain Disease

AU - Pochigaeva, Ksenia

AU - Druzhkova, Tatiana

AU - Yakovlev, Alexander

AU - Onufriev, Mikhail

AU - Grishkina, Maria

AU - Chepelev, Aleksey

AU - Guekht, Alla

AU - Gulyaeva, Natalia

PY - 2017

DA - 2017/01/07 00:00:00

PB - Springer Nature

SP - 577-583

IS - 2

VL - 32

SN - 0885-7490

SN - 1573-7365

ER -

BibTex |

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BibTex Copy

@article{2017_Pochigaeva,

author = {Ksenia Pochigaeva and Tatiana Druzhkova and Alexander Yakovlev and Mikhail Onufriev and Maria Grishkina and Aleksey Chepelev and Alla Guekht and Natalia Gulyaeva},

title = {Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder},

journal = {Metabolic Brain Disease},

year = {2017},

volume = {32},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1007%2Fs11011-017-9952-0},

number = {2},

pages = {577--583},

doi = {10.1007/s11011-017-9952-0}

}

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Pochigaeva, Ksenia, et al. “Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder.” Metabolic Brain Disease, vol. 32, no. 2, Jan. 2017, pp. 577-583. https://doi.org/10.1007%2Fs11011-017-9952-0.

Found error?

Publisher

Springer Nature

Journal

Metabolic Brain Disease

Quartile SCImago

Quartile WOS

Impact factor

3.6

ISSN

08857490 (Print)
15737365 (Electronic)

Labs

Laboratory of Functional Biochemistry of the Nervous System

Profiles

Gulyaeva, Natalia V