Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1- Carboxymethyl-3-Pyrrolin-2-Ones

Publication type: Journal Article
Publication date: 2023-05-10
Springer Nature
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
5-Aryl-4-(4-halobenzoyl)-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones were obtained by a three-component reaction of methyl esters of p-halobenzoylpyruvic acids with a mixture of aromatic aldehyde and glycine in glacial acetic acid in the presence of anhydrous sodium acetate. The analgesic activity of the obtained compounds was studied using the hot-plate method. Their anti-inflammatory activity was determined using the aseptic carrageenan inflammation model. It was shown that all compounds under study exhibit pronounced analgesic activity while compound III also had pronounced anti-exudative activity.
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Pastukhova E. V. et al. Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1- Carboxymethyl-3-Pyrrolin-2-Ones // Pharmaceutical Chemistry Journal. 2023.
GOST all authors (up to 50) Copy
Pastukhova E. V., Chashchina S. V., Buldakova E. A., Gein V. L., Mokrushin I. G. Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1- Carboxymethyl-3-Pyrrolin-2-Ones // Pharmaceutical Chemistry Journal. 2023.
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TY - JOUR
DO - 10.1007/s11094-023-02870-9
UR - https://doi.org/10.1007/s11094-023-02870-9
TI - Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1- Carboxymethyl-3-Pyrrolin-2-Ones
T2 - Pharmaceutical Chemistry Journal
AU - Pastukhova, E V
AU - Chashchina, S V
AU - Buldakova, E A
AU - Gein, V L
AU - Mokrushin, I G
PY - 2023
DA - 2023/05/10
PB - Springer Nature
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2023_Pastukhova,
author = {E V Pastukhova and S V Chashchina and E A Buldakova and V L Gein and I G Mokrushin},
title = {Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1- Carboxymethyl-3-Pyrrolin-2-Ones},
journal = {Pharmaceutical Chemistry Journal},
year = {2023},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s11094-023-02870-9},
doi = {10.1007/s11094-023-02870-9}
}