Pharmaceutical Chemistry Journal

, volume 57 , issue 11 , pages 1703-1708

Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic

V V Eremina ¹

D A Kulagina ¹

S G Krylova ²

E. A. Kiseleva ²

T N Povetyeva ²

E P Zueva ²

N I Suslov ²

S. V. Sysolyatin ¹

V. V. Zhdanov ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences (IPCET SB RAS), Biysk, Russia |

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia |

Publication type: Journal Article

Publication date: 2024-02-01

Springer Nature

Pharmaceutical Chemistry Journal

scimago Q4

wos Q4

SJR: 0.219

CiteScore: 1.4

Impact factor: 1.0

ISSN: 0091150X, 15739031

DOI: 10.1007/s11094-024-03068-3

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Drug Discovery

Pharmacology

Abstract

A modified method for the synthesis of a promising non-narcotic analgesic agent of the hexaazaisowurtzitane class with pronounced anti-inflammatory activity is described. Methods for reducing the cost of the target substance are considered. The physicochemical characteristics are described. The efficacy and safety of the synthesized agent are shown in several animal models.

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Eremina V. V. et al. Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic // Pharmaceutical Chemistry Journal. 2024. Vol. 57. No. 11. pp. 1703-1708.

GOST all authors (up to 50) Copy

Eremina V. V., Kulagina D. A., Krylova S. G., Kiseleva E. A., Povetyeva T. N., Zueva E. P., Suslov N. I., Sysolyatin S. V., Zhdanov V. V. Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic // Pharmaceutical Chemistry Journal. 2024. Vol. 57. No. 11. pp. 1703-1708.

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TY - JOUR

DO - 10.1007/s11094-024-03068-3

UR - https://doi.org/10.1007/s11094-024-03068-3

TI - Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic

T2 - Pharmaceutical Chemistry Journal

AU - Eremina, V V

AU - Kulagina, D A

AU - Krylova, S G

AU - Kiseleva, E. A.

AU - Povetyeva, T N

AU - Zueva, E P

AU - Suslov, N I

AU - Sysolyatin, S. V.

AU - Zhdanov, V. V.

PY - 2024

DA - 2024/02/01

PB - Springer Nature

SP - 1703-1708

IS - 11

VL - 57

SN - 0091-150X

SN - 1573-9031

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2024_Eremina,

author = {V V Eremina and D A Kulagina and S G Krylova and E. A. Kiseleva and T N Povetyeva and E P Zueva and N I Suslov and S. V. Sysolyatin and V. V. Zhdanov},

title = {Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic},

journal = {Pharmaceutical Chemistry Journal},

year = {2024},

volume = {57},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1007/s11094-024-03068-3},

number = {11},

pages = {1703--1708},

doi = {10.1007/s11094-024-03068-3}

}

MLA

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Eremina, V. V., et al. “Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic.” Pharmaceutical Chemistry Journal, vol. 57, no. 11, Feb. 2024, pp. 1703-1708. https://doi.org/10.1007/s11094-024-03068-3.