Springer Nature
Pharmaceutical Chemistry Journal
,  volume 57 ,  issue 11 ,  pages 1815-1821

Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma

S. N. Baskhanova 1, 2
, 
M. V. Savitskii 2, 3
, 
N E Moskaleva 1
, 
V M Samoylov 4
, 
N. L. Lubenec 5
, 
S I Luyksaar 5
, 
A V Soloveva 5
, 
C. A. Zolotov 5
, 
N A Zigangirova 5
, 
S A Appolonova 1, 3
1
 
2
 
3
 
4
 
5
 
Publication type: Journal Article
Publication date: 2024-02-01
Springer Nature
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
An HPLC-MS/MS technique for quantitative determination of the new antibacterial drug fluorothiazinone in human blood plasma using an internal standard was developed and validated. The validation protocol proved the selectivity, accuracy, and precision of the method and the lack of significant carryover, matrix, and sample-dilution effects. The calibration curve was linear in the concentration range 0.1 – 300 ng/mL with a correlation coefficient r2 > 0.9990. The lower limit of quantitation was 0.1 ng/mL. The studied analyte was shown to be stable during storage in a stock solution (for 6 h at room temperature) and in plasma samples (for 6 h at room temperature, after three freeze–thaw cycles, and for 30 d at –70°C) and in an autosampler after sample preparation (for 24 h at +10°C).
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Baskhanova S. N. et al. Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma // Pharmaceutical Chemistry Journal. 2024. Vol. 57. No. 11. pp. 1815-1821.
GOST all authors (up to 50) Copy
Baskhanova S. N., Savitskii M. V., Moskaleva N. E., Samoylov V. M., Lubenec N. L., Luyksaar S. I., Soloveva A. V., Zolotov C. A., Zigangirova N. A., Appolonova S. A. Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma // Pharmaceutical Chemistry Journal. 2024. Vol. 57. No. 11. pp. 1815-1821.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11094-024-03083-4
UR - https://doi.org/10.1007/s11094-024-03083-4
TI - Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma
T2 - Pharmaceutical Chemistry Journal
AU - Baskhanova, S. N.
AU - Savitskii, M. V.
AU - Moskaleva, N E
AU - Samoylov, V M
AU - Lubenec, N. L.
AU - Luyksaar, S I
AU - Soloveva, A V
AU - Zolotov, C. A.
AU - Zigangirova, N A
AU - Appolonova, S A
PY - 2024
DA - 2024/02/01
PB - Springer Nature
SP - 1815-1821
IS - 11
VL - 57
SN - 0091-150X
SN - 1573-9031
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Baskhanova,
author = {S. N. Baskhanova and M. V. Savitskii and N E Moskaleva and V M Samoylov and N. L. Lubenec and S I Luyksaar and A V Soloveva and C. A. Zolotov and N A Zigangirova and S A Appolonova},
title = {Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma},
journal = {Pharmaceutical Chemistry Journal},
year = {2024},
volume = {57},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s11094-024-03083-4},
number = {11},
pages = {1815--1821},
doi = {10.1007/s11094-024-03083-4}
}
MLA
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MLA Copy
Baskhanova, S. N., et al. “Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma.” Pharmaceutical Chemistry Journal, vol. 57, no. 11, Feb. 2024, pp. 1815-1821. https://doi.org/10.1007/s11094-024-03083-4.