Synthesis of 8-carboxamide-substituted angelicin derivatives
S. R. Klyatskina
1
,
A S Olshanova
1
,
N. D. Dagaev
1
,
N I Vorozhtsov
1
,
D A Skvortsov
1
,
D A Vasilenko
1
,
E B Averina
1
,
N. V. Zyk
1
,
Publication type: Journal Article
Publication date: 2023-07-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
A method for the synthesis of 4-methyl-2-oxo-9-phenyl-2H-furo[2,3-h]chromene-8-carboxylic acid amides combining in the structure the angelicin core with heterocyclic fragments at the amide nitrogen atom was developed. The cytotoxic activity of the obtained amides against the MCF7 (breast adenocarcinoma), A549 (non-small cell lung cancer), VA-13 (embryonic lung fibroblast cells) and HEK293T (embryonic kidney cells) cell lines was studied. In contrast to the previously described highly toxic angelicin derivatives with aryl- and hetarylcarbonyl substituents at position 8, the synthesized amides demonstrated in in vitro experiments in these cell lines the IC50abs values ranging within 2–100 µmol L−1. The cytotoxicity and selectivity of the action of this group of derivatives were found to be significantly affected by the substituent at position 5′ of the angelicin moiety.
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Klyatskina S. R. et al. Synthesis of 8-carboxamide-substituted angelicin derivatives // Russian Chemical Bulletin. 2023. Vol. 72. No. 7. pp. 1598-1605.
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Klyatskina S. R., Olshanova A. S., Dagaev N. D., Vorozhtsov N. I., Skvortsov D. A., Vasilenko D. A., Averina E. B., Zyk N. V., Beloglazkina E. K. Synthesis of 8-carboxamide-substituted angelicin derivatives // Russian Chemical Bulletin. 2023. Vol. 72. No. 7. pp. 1598-1605.
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TY - JOUR
DO - 10.1007/s11172-023-3939-2
UR - https://link.springer.com/10.1007/s11172-023-3939-2
TI - Synthesis of 8-carboxamide-substituted angelicin derivatives
T2 - Russian Chemical Bulletin
AU - Klyatskina, S. R.
AU - Olshanova, A S
AU - Dagaev, N. D.
AU - Vorozhtsov, N I
AU - Skvortsov, D A
AU - Vasilenko, D A
AU - Averina, E B
AU - Zyk, N. V.
AU - Beloglazkina, E K
PY - 2023
DA - 2023/07/01
PB - Springer Nature
SP - 1598-1605
IS - 7
VL - 72
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2023_Klyatskina,
author = {S. R. Klyatskina and A S Olshanova and N. D. Dagaev and N I Vorozhtsov and D A Skvortsov and D A Vasilenko and E B Averina and N. V. Zyk and E K Beloglazkina},
title = {Synthesis of 8-carboxamide-substituted angelicin derivatives},
journal = {Russian Chemical Bulletin},
year = {2023},
volume = {72},
publisher = {Springer Nature},
month = {jul},
url = {https://link.springer.com/10.1007/s11172-023-3939-2},
number = {7},
pages = {1598--1605},
doi = {10.1007/s11172-023-3939-2}
}
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MLA
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Klyatskina, S. R., et al. “Synthesis of 8-carboxamide-substituted angelicin derivatives.” Russian Chemical Bulletin, vol. 72, no. 7, Jul. 2023, pp. 1598-1605. https://link.springer.com/10.1007/s11172-023-3939-2.