Springer Nature
Metabolomics
,  volume 19 ,  issue 6 ,  publication number 53

Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid

Eulalia Olesti 1, 2, 3
, 
Julien Boccard 1, 2, 3
, 
Rita Rahban 3, 4
, 
Sergey Girel 1, 2
, 
Natalia E Moskaleva 5
, 
Fanny Zufferey 3, 6
, 
Michel F. Rossier 3, 6, 7
, 
Serge Nef 3, 4
, 
Serge Rudaz 1, 2, 3
, 
Víctor González Ruiz 1, 2, 3, 8
1
 
2
 
3
 
Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland | 
4
 
5
 
6
 
Service of Clinical Chemistry & Toxicology, Central Institute of Hospitals, Hospital of Valais, Sion, Switzerland | 
7
 
8
 
Publication type: Journal Article
Publication date: 2023-06-05
Springer Nature
scimago Q2
wos Q2
SJR: 0.835
CiteScore: 5.5
Impact factor: 3.3
ISSN: 15733882, 15733890
Biochemistry
Clinical Biochemistry
Endocrinology, Diabetes and Metabolism
Abstract
Introduction

A decrease in sperm cell count has been observed along the last several decades, especially in the most developed regions of the world. The use of metabolomics to study the composition of the seminal fluid is a promising approach to gain access to the molecular mechanisms underlying this fact.

Objectives

In the present work, we aimed at relating metabolomic profiles of young healthy men to their semen quality parameters obtained from conventional microscopic analysis.

Methods

An untargeted metabolomics approach focusing on low- to mid-polarity compounds was used to analyze a subset of seminal fluid samples from a cohort of over 2700 young healthy men.

Results

Our results show that a broad metabolic profiling comprising several families of compounds (including acyl-carnitines, steroids, and other lipids) can contribute to effectively distinguish samples provided by individuals exhibiting low or high absolute sperm counts.

Conclusion

A number of metabolites involved in sexual development and function, signaling, and energy metabolism were highlighted as being distinctive of samples coming from either group, proving untargeted metabolomics as a promising tool to better understand the pathophysiological processes responsible for male fertility impairment.

Found 
Found 

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GOST Copy
Olesti E. et al. Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid // Metabolomics. 2023. Vol. 19. No. 6. 53
GOST all authors (up to 50) Copy
Olesti E., Boccard J., Rahban R., Girel S., Moskaleva N. E., Zufferey F., Rossier M. F., Nef S., Rudaz S., González Ruiz V. Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid // Metabolomics. 2023. Vol. 19. No. 6. 53
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s11306-023-02020-y
UR - https://doi.org/10.1007/s11306-023-02020-y
TI - Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid
T2 - Metabolomics
AU - Olesti, Eulalia
AU - Boccard, Julien
AU - Rahban, Rita
AU - Girel, Sergey
AU - Moskaleva, Natalia E
AU - Zufferey, Fanny
AU - Rossier, Michel F.
AU - Nef, Serge
AU - Rudaz, Serge
AU - González Ruiz, Víctor
PY - 2023
DA - 2023/06/05
PB - Springer Nature
IS - 6
VL - 19
PMID - 37271779
SN - 1573-3882
SN - 1573-3890
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Olesti,
author = {Eulalia Olesti and Julien Boccard and Rita Rahban and Sergey Girel and Natalia E Moskaleva and Fanny Zufferey and Michel F. Rossier and Serge Nef and Serge Rudaz and Víctor González Ruiz},
title = {Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid},
journal = {Metabolomics},
year = {2023},
volume = {19},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s11306-023-02020-y},
number = {6},
pages = {53},
doi = {10.1007/s11306-023-02020-y}
}