Metabolomics, volume 19, issue 9, publication number 77
Metabolomics of head and neck cancer in biofluids: an integrative systematic review
Chuchueva Natalia
1, 2
,
Carta Filippo
3
,
Nguyen Hoang N
2
,
Luevano Jennifer
4
,
Lewis Isaiah A.
4
,
Rios‐Castillo Israel
5
,
Fanos Vassilios
6
,
King Emma
7, 8
,
Swistushkin Valery
2
,
Reshetov Igor
2
,
Rusetsky Yury
1, 9
,
Shestakova Ksenia
10, 11
,
Moskaleva Natalia
10, 11
,
Mariani Cinzia
3
,
Castillo Carniglia Alvaro
12, 13
,
Grapov Dmitry
14
,
Fahrmann Johannes
15
,
La Frano Michael R
4, 16, 17
,
Puxeddu Roberto
18, 19
,
Appolonova Svetlana A
11, 20
,
Brito Alex
10, 11
4
Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, USA
|
5
Medical School, University of Panama, Panama City, Panama
|
8
Department of Otolaryngology, Poole Hospital National Health Service Foundation Trust, Poole, UK
|
12
Society and Health Research Center, Facultad de Ciencias Sociales y Artes, Universidad Mayor, Santiago, Chile
|
13
Millennium Nucleus for the Evaluation and Analysis of Drug Policies (nDP) and Millennium Nucleus on Sociomedicine (SocioMed), Santiago, Chile
|
14
CDS-Creative Data Solutions, Colfax, USA
|
15
MD Anderson Cancer Center, Houston, USA
|
16
Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, USA
|
17
Roy J.Carver Metabolomics Core Facility, University of Illinois, Urbana-Champaign, USA
|
19
King’s College Hospital London, Dubai, United Arab Emirates
|
20
Russian Center of Forensic-Medical Expertise of Ministry of Health, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2023-08-29
Journal:
Metabolomics
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.6
ISSN: 15733882, 15733890
Biochemistry
Clinical Biochemistry
Endocrinology, Diabetes and Metabolism
Abstract
Head and neck cancer (HNC) is the fifth most common cancer globally. Diagnosis at early stages are critical to reduce mortality and improve functional and esthetic outcomes associated with HNC. Metabolomics is a promising approach for discovery of biomarkers and metabolic pathways for risk assessment and early detection of HNC. To summarize and consolidate the available evidence on metabolomics and HNC in plasma/serum, saliva, and urine. A systematic search of experimental research was executed using PubMed and Web of Science. Available data on areas under the curve was extracted. Metabolic pathway enrichment analysis were performed to identify metabolic pathways altered in HNC. Fifty-four studies were eligible for data extraction (33 performed in plasma/serum, 15 in saliva and 6 in urine). Metabolites with high discriminatory performance for detection of HNC included single metabolites and combination panels of several lysoPCs, pyroglutamate, glutamic acid, glucose, tartronic acid, arachidonic acid, norvaline, linoleic acid, propionate, acetone, acetate, choline, glutamate and others. The glucose-alanine cycle and the urea cycle were the most altered pathways in HNC, among other pathways (i.e. gluconeogenesis, glycine and serine metabolism, alanine metabolism, etc.). Specific metabolites that can potentially serve as complementary less- or non-invasive biomarkers, as well as metabolic pathways integrating the data from the available studies, are presented. The present work highlights utility of metabolite-based biomarkers for risk assessment, early detection, and prognostication of HNC, as well as facilitates incorporation of available metabolomics studies into multi-omics data integration and big data analytics for personalized health.
Citations by journals
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Metabolites
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Metabolites
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 100%
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Chuchueva N. et al. Metabolomics of head and neck cancer in biofluids: an integrative systematic review // Metabolomics. 2023. Vol. 19. No. 9. 77
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Chuchueva N., Carta F., Nguyen H. N., Luevano J., Lewis I. A., Rios‐Castillo I., Fanos V., King E., Swistushkin V., Reshetov I., Rusetsky Y., Shestakova K., Moskaleva N., Mariani C., Castillo Carniglia A., Grapov D., Fahrmann J., La Frano M. R., Puxeddu R., Appolonova S. A., Brito A. Metabolomics of head and neck cancer in biofluids: an integrative systematic review // Metabolomics. 2023. Vol. 19. No. 9. 77
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TY - JOUR
DO - 10.1007/s11306-023-02038-2
UR - https://doi.org/10.1007%2Fs11306-023-02038-2
TI - Metabolomics of head and neck cancer in biofluids: an integrative systematic review
T2 - Metabolomics
AU - Chuchueva, Natalia
AU - Carta, Filippo
AU - Nguyen, Hoang N
AU - Luevano, Jennifer
AU - Lewis, Isaiah A.
AU - Rios‐Castillo, Israel
AU - Fanos, Vassilios
AU - King, Emma
AU - Swistushkin, Valery
AU - Reshetov, Igor
AU - Rusetsky, Yury
AU - Shestakova, Ksenia
AU - Moskaleva, Natalia
AU - Mariani, Cinzia
AU - Castillo Carniglia, Alvaro
AU - Grapov, Dmitry
AU - Fahrmann, Johannes
AU - La Frano, Michael R
AU - Puxeddu, Roberto
AU - Appolonova, Svetlana A
AU - Brito, Alex
PY - 2023
DA - 2023/08/29 00:00:00
PB - Springer Nature
IS - 9
VL - 19
SN - 1573-3882
SN - 1573-3890
ER -
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@article{2023_Chuchueva,
author = {Natalia Chuchueva and Filippo Carta and Hoang N Nguyen and Jennifer Luevano and Isaiah A. Lewis and Israel Rios‐Castillo and Vassilios Fanos and Emma King and Valery Swistushkin and Igor Reshetov and Yury Rusetsky and Ksenia Shestakova and Natalia Moskaleva and Cinzia Mariani and Alvaro Castillo Carniglia and Dmitry Grapov and Johannes Fahrmann and Michael R La Frano and Roberto Puxeddu and Svetlana A Appolonova and Alex Brito},
title = {Metabolomics of head and neck cancer in biofluids: an integrative systematic review},
journal = {Metabolomics},
year = {2023},
volume = {19},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007%2Fs11306-023-02038-2},
number = {9},
doi = {10.1007/s11306-023-02038-2}
}