Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells
Masayuki Ninomiya
1
,
Kyohei Nishida
1
,
Kaori Tanaka
2, 3
,
Kunitomo WATANABE
2, 3
,
Mamoru Koketsu
1
1
Publication type: Journal Article
Publication date: 2012-08-02
scimago Q1
wos Q3
SJR: 0.569
CiteScore: 5.7
Impact factor: 2.5
ISSN: 13403443, 18610293
PubMed ID:
22855403
Molecular Medicine
Abstract
Flavonoids are widely occurring polyphenols that are found in plants. The aim of this study was to investigate the structure–activity relationships of 5,7-dihydroxyflavones, with a focus on the effect of B ring structure substitution on the antiproliferative effects of the compounds in human leukemia HL-60 cells. We prepared a series of 5,7-dihydroxyflavones and evaluated their ability to inhibit the proliferation of HL-60 cells by using the MTT assay. The apoptosis- and cell differentiation-inducing ability of the most potent flavones were investigated using staining and morphological analyses. This study explored the antileukemic and chemopreventive potency of 5,7-dihydroxyflavones, particularly diosmetin and chrysoeriol, which have both hydroxy and methoxy groups on the B ring.
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Total citations:
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Citations from 2024:
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(16.67%)
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GOST
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Ninomiya M. et al. Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells // Journal of Natural Medicines. 2012. Vol. 67. No. 3. pp. 460-467.
GOST all authors (up to 50)
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Ninomiya M., Nishida K., Tanaka K., WATANABE K., Koketsu M. Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells // Journal of Natural Medicines. 2012. Vol. 67. No. 3. pp. 460-467.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11418-012-0697-0
UR - https://doi.org/10.1007/s11418-012-0697-0
TI - Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells
T2 - Journal of Natural Medicines
AU - Ninomiya, Masayuki
AU - Nishida, Kyohei
AU - Tanaka, Kaori
AU - WATANABE, Kunitomo
AU - Koketsu, Mamoru
PY - 2012
DA - 2012/08/02
PB - Springer Nature
SP - 460-467
IS - 3
VL - 67
PMID - 22855403
SN - 1340-3443
SN - 1861-0293
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Ninomiya,
author = {Masayuki Ninomiya and Kyohei Nishida and Kaori Tanaka and Kunitomo WATANABE and Mamoru Koketsu},
title = {Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells},
journal = {Journal of Natural Medicines},
year = {2012},
volume = {67},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s11418-012-0697-0},
number = {3},
pages = {460--467},
doi = {10.1007/s11418-012-0697-0}
}
Cite this
MLA
Copy
Ninomiya, Masayuki, et al. “Structure–activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells.” Journal of Natural Medicines, vol. 67, no. 3, Aug. 2012, pp. 460-467. https://doi.org/10.1007/s11418-012-0697-0.