Archives of Pharmacal Research

, том 32 , издание 6 , страницы 851-855

Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes

Eun Ju Choi ^{1, 2}

Hak Cheol Kwon ¹

Young Chang Sohn ²

Chun-Woo Nam ³

Hyun Bong Park ^{1, 4}

Cheol Young Kim ¹

Hyun-Ok Yang ^{1, 5}

Скрыть аффилиации авторов Показать аффилиации авторов: 5 аффилиаций

Korea Institute of Science and Technology, Gangneung Institute, Gangneung, Korea |

Faculty of Marine Bioscience and Technology, Kangnung-Wonju National University, Gangneung, Korea |

National Institute of Highland Agriculture, Pyeongchang, Korea |

⁴

Faculty of Natural Science, Kangnung-Wonju National University, Gangneung, Korea |

⁵

KIST Gangneung Institute, Gangneung, Korea |

Тип публикации: Journal Article

Дата публикации: 2009-06-25

Pharmaceutical Society of Korea

Archives of Pharmacal Research

scimago Q1

wos Q1

БС1

SJR: 1.870

CiteScore: 14.4

Impact factor: 7.5

ISSN: 02536269, 19763786

DOI: 10.1007/s12272-009-1606-2

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PubMed ID: 19557362

Organic Chemistry

Drug Discovery

Molecular Medicine

Краткое описание

A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 μg/mL and 50 μg/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent ‘hangovers’ after alcohol intake.

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Choi E. J. et al. Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes // Archives of Pharmacal Research. 2009. Vol. 32. No. 6. pp. 851-855.

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Choi E. J., Kwon H. C., Sohn Y. C., Nam C., Park H. B., Kim C. Y., Yang H. Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes // Archives of Pharmacal Research. 2009. Vol. 32. No. 6. pp. 851-855.

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TY - JOUR

DO - 10.1007/s12272-009-1606-2

UR - https://doi.org/10.1007/s12272-009-1606-2

TI - Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes

T2 - Archives of Pharmacal Research

AU - Choi, Eun Ju

AU - Kwon, Hak Cheol

AU - Sohn, Young Chang

AU - Nam, Chun-Woo

AU - Park, Hyun Bong

AU - Kim, Cheol Young

AU - Yang, Hyun-Ok

PY - 2009

DA - 2009/06/25

PB - Pharmaceutical Society of Korea

SP - 851-855

IS - 6

VL - 32

PMID - 19557362

SN - 0253-6269

SN - 1976-3786

ER -

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@article{2009_Choi,

author = {Eun Ju Choi and Hak Cheol Kwon and Young Chang Sohn and Chun-Woo Nam and Hyun Bong Park and Cheol Young Kim and Hyun-Ok Yang},

title = {Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes},

journal = {Archives of Pharmacal Research},

year = {2009},

volume = {32},

publisher = {Pharmaceutical Society of Korea},

month = {jun},

url = {https://doi.org/10.1007/s12272-009-1606-2},

number = {6},

pages = {851--855},

doi = {10.1007/s12272-009-1606-2}

}

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Choi, Eun Ju, et al. “Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes.” Archives of Pharmacal Research, vol. 32, no. 6, Jun. 2009, pp. 851-855. https://doi.org/10.1007/s12272-009-1606-2.

Издатель

Pharmaceutical Society of Korea

Журнал

Archives of Pharmacal Research

scimago Q1

wos Q1

БС1

SJR

1.870

CiteScore

14.4

Impact factor

7.5

ISSN

02536269 (Print)

19763786 (Electronic)