том 88 издание 2 страницы 157-160

The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

Тип публикацииJournal Article
Дата публикации1992-06-01
scimago Q1
wos Q1
БС1
SJR1.107
CiteScore6.7
Impact factor4
ISSN03009564, 14351463
Neurology
Psychiatry and Mental health
Biological Psychiatry
Neurology (clinical)
Краткое описание
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates.
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ГОСТ |
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Hyttel J. et al. The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer // Journal of Neural Transmission. 1992. Vol. 88. No. 2. pp. 157-160.
ГОСТ со всеми авторами (до 50) Скопировать
Hyttel J., Bges K. P., Perregaard J., S??nchez C. The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer // Journal of Neural Transmission. 1992. Vol. 88. No. 2. pp. 157-160.
RIS |
Цитировать
TY - JOUR
DO - 10.1007/bf01244820
UR - https://doi.org/10.1007/bf01244820
TI - The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer
T2 - Journal of Neural Transmission
AU - Hyttel, J.
AU - Bges, K P
AU - Perregaard, J.
AU - S??nchez, C
PY - 1992
DA - 1992/06/01
PB - Springer Nature
SP - 157-160
IS - 2
VL - 88
PMID - 1632943
SN - 0300-9564
SN - 1435-1463
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{1992_Hyttel,
author = {J. Hyttel and K P Bges and J. Perregaard and C S??nchez},
title = {The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer},
journal = {Journal of Neural Transmission},
year = {1992},
volume = {88},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/bf01244820},
number = {2},
pages = {157--160},
doi = {10.1007/bf01244820}
}
MLA
Цитировать
Hyttel, J., et al. “The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer.” Journal of Neural Transmission, vol. 88, no. 2, Jun. 1992, pp. 157-160. https://doi.org/10.1007/bf01244820.