Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
3
University of Arizonc, Tucson, USA
|
Publication type: Journal Article
Publication date: 1989-02-01
scimago Q1
wos Q1
SJR: 2.299
CiteScore: 12.5
Impact factor: 6.2
ISSN: 1420682X, 14209071
PubMed ID:
2920809
Molecular Biology
Pharmacology
Cell Biology
Molecular Medicine
Cellular and Molecular Neuroscience
Abstract
The African treeCombretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502–3 μM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50≈0.003 μM and human colon cancer cell lines [(e.g. LoVo (ED50=0.005 μg/ml), HT29 (ED50 0.02 μg/ml, Colo 205 (ED50=0.07 μg/ml), DLD-1 (ED50=0.005 μg/ml) and HCT-15 (ED50=0.0009 μg/ml)] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
10
20
30
40
50
60
70
|
|
|
European Journal of Medicinal Chemistry
69 publications, 10.03%
|
|
|
Bioorganic and Medicinal Chemistry
52 publications, 7.56%
|
|
|
Journal of Medicinal Chemistry
51 publications, 7.41%
|
|
|
Bioorganic and Medicinal Chemistry Letters
45 publications, 6.54%
|
|
|
ChemMedChem
18 publications, 2.62%
|
|
|
Bioorganic Chemistry
16 publications, 2.33%
|
|
|
Journal of Natural Products
14 publications, 2.03%
|
|
|
MedChemComm
13 publications, 1.89%
|
|
|
Tetrahedron Letters
10 publications, 1.45%
|
|
|
RSC Advances
9 publications, 1.31%
|
|
|
Journal of Organic Chemistry
8 publications, 1.16%
|
|
|
Scientific Reports
8 publications, 1.16%
|
|
|
Tetrahedron
7 publications, 1.02%
|
|
|
Pharmaceuticals
7 publications, 1.02%
|
|
|
Organic and Biomolecular Chemistry
7 publications, 1.02%
|
|
|
European Journal of Organic Chemistry
6 publications, 0.87%
|
|
|
Russian Chemical Bulletin
6 publications, 0.87%
|
|
|
Molecules
6 publications, 0.87%
|
|
|
Medicinal Chemistry Research
6 publications, 0.87%
|
|
|
Journal of Enzyme Inhibition and Medicinal Chemistry
6 publications, 0.87%
|
|
|
Anti-Cancer Drugs
5 publications, 0.73%
|
|
|
British Journal of Cancer
5 publications, 0.73%
|
|
|
Studies in Natural Products Chemistry
5 publications, 0.73%
|
|
|
Cancer Chemotherapy and Pharmacology
4 publications, 0.58%
|
|
|
International Journal of Cancer
4 publications, 0.58%
|
|
|
Archiv der Pharmazie
4 publications, 0.58%
|
|
|
Natural Product Reports
4 publications, 0.58%
|
|
|
Expert Opinion on Therapeutic Patents
4 publications, 0.58%
|
|
|
Synthesis
4 publications, 0.58%
|
|
|
10
20
30
40
50
60
70
|
Publishers
|
50
100
150
200
250
300
|
|
|
Elsevier
263 publications, 38.23%
|
|
|
American Chemical Society (ACS)
93 publications, 13.52%
|
|
|
Wiley
87 publications, 12.65%
|
|
|
Springer Nature
66 publications, 9.59%
|
|
|
Royal Society of Chemistry (RSC)
37 publications, 5.38%
|
|
|
Taylor & Francis
32 publications, 4.65%
|
|
|
MDPI
24 publications, 3.49%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
8 publications, 1.16%
|
|
|
Bentham Science Publishers Ltd.
7 publications, 1.02%
|
|
|
American Association for Cancer Research (AACR)
6 publications, 0.87%
|
|
|
Georg Thieme Verlag KG
6 publications, 0.87%
|
|
|
Spandidos Publications
4 publications, 0.58%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
3 publications, 0.44%
|
|
|
Impact Journals
3 publications, 0.44%
|
|
|
SAGE
3 publications, 0.44%
|
|
|
Public Library of Science (PLoS)
3 publications, 0.44%
|
|
|
Pleiades Publishing
3 publications, 0.44%
|
|
|
American Society of Clinical Oncology (ASCO)
3 publications, 0.44%
|
|
|
Mary Ann Liebert
2 publications, 0.29%
|
|
|
Pharmaceutical Society of Japan
2 publications, 0.29%
|
|
|
Frontiers Media S.A.
2 publications, 0.29%
|
|
|
Society for Translational Oncology
2 publications, 0.29%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 0.29%
|
|
|
Hindawi Limited
2 publications, 0.29%
|
|
|
American Society of Hematology
2 publications, 0.29%
|
|
|
S. Karger AG
2 publications, 0.29%
|
|
|
International Union of Crystallography (IUCr)
1 publication, 0.15%
|
|
|
IOP Publishing
1 publication, 0.15%
|
|
|
Neoplasia Press
1 publication, 0.15%
|
|
|
50
100
150
200
250
300
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
689
Total citations:
689
Citations from 2024:
43
(6.25%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Pettit G. R. et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4 // Cellular and Molecular Life Sciences. 1989. Vol. 45. No. 2. pp. 209-211.
GOST all authors (up to 50)
Copy
Pettit G. R., Singh S. B., Hamel E., Lin C. M., Alberts D. S., Garcia Kendal D. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4 // Cellular and Molecular Life Sciences. 1989. Vol. 45. No. 2. pp. 209-211.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/BF01954881
UR - https://doi.org/10.1007/BF01954881
TI - Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
T2 - Cellular and Molecular Life Sciences
AU - Pettit, G R
AU - Singh, S. B.
AU - Hamel, E.
AU - Lin, C. M.
AU - Alberts, D. S.
AU - Garcia Kendal, D
PY - 1989
DA - 1989/02/01
PB - Springer Nature
SP - 209-211
IS - 2
VL - 45
PMID - 2920809
SN - 1420-682X
SN - 1420-9071
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1989_Pettit,
author = {G R Pettit and S. B. Singh and E. Hamel and C. M. Lin and D. S. Alberts and D Garcia Kendal},
title = {Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4},
journal = {Cellular and Molecular Life Sciences},
year = {1989},
volume = {45},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/BF01954881},
number = {2},
pages = {209--211},
doi = {10.1007/BF01954881}
}
Cite this
MLA
Copy
Pettit, G. R., et al. “Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.” Cellular and Molecular Life Sciences, vol. 45, no. 2, Feb. 1989, pp. 209-211. https://doi.org/10.1007/BF01954881.