Medicinal Chemistry Research

, том 25 , издание 1 , страницы 30-39

nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα

Тип публикации: Journal Article

Дата публикации: 2015-09-15

Springer Nature

Medicinal Chemistry Research

SCImago Q2

WOS Q2

БС2

SJR: 0.501

CiteScore: 5.5

Impact factor: 3.5

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-015-1446-1

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Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

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An original, effective approach to the stereoselective method for the synthesis of higher unsaturated acids containing a 1Z,5Z-diene group in 61–75 % yields and with >98 % selectivity based on the new intermolecular Cp2TiCl2-catalyzed cross-cyclomagnesiation of terminal aliphatic and O-containing 1,2-diene with Grignard reagents has been developed. The inhibitory action of the obtained dienoic acids on the human topoisomerase I and II was studied. Resorting to the data of molecular docking, a probable mechanism of inhibition was proposed.

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D'yakonov V. A. et al. nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα // Medicinal Chemistry Research. 2015. Vol. 25. No. 1. pp. 30-39.

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D'yakonov V. A., Dzhemileva L. U., Makarov A. A., Mulyukova A. R., Baev D. S., Khusnutdinova E. K., Tolstikova T. G., Dzhemilev U. M. nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα // Medicinal Chemistry Research. 2015. Vol. 25. No. 1. pp. 30-39.

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TY - JOUR

DO - 10.1007/s00044-015-1446-1

UR - https://doi.org/10.1007/s00044-015-1446-1

TI - nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα

T2 - Medicinal Chemistry Research

AU - D'yakonov, Vladimir A.

AU - Dzhemileva, Lilya U.

AU - Makarov, Aleksey A

AU - Mulyukova, Alfiya R

AU - Baev, Dmitry S.

AU - Khusnutdinova, Elza K.

AU - Tolstikova, Tatiana G.

AU - Dzhemilev, Usein M.

PY - 2015

DA - 2015/09/15

PB - Springer Nature

SP - 30-39

IS - 1

VL - 25

SN - 1054-2523

SN - 1554-8120

ER -

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@article{2015_D'yakonov,

author = {Vladimir A. D'yakonov and Lilya U. Dzhemileva and Aleksey A Makarov and Alfiya R Mulyukova and Dmitry S. Baev and Elza K. Khusnutdinova and Tatiana G. Tolstikova and Usein M. Dzhemilev},

title = {nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα},

journal = {Medicinal Chemistry Research},

year = {2015},

volume = {25},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1007/s00044-015-1446-1},

number = {1},

pages = {30--39},

doi = {10.1007/s00044-015-1446-1}

}

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MLA Скопировать

D'yakonov, Vladimir A., et al. “nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα.” Medicinal Chemistry Research, vol. 25, no. 1, Sep. 2015, pp. 30-39. https://doi.org/10.1007/s00044-015-1446-1.

Издатель

Springer Nature

Журнал

Medicinal Chemistry Research

SCImago Q2

WOS Q2

БС2

SJR

0.501

CiteScore

5.5

Impact factor