Medicinal Chemistry Research

, volume 25 , issue 1 , pages 30-39

nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα

Vladimir A. D'yakonov ¹

Lilya U. Dzhemileva ²

Aleksey A Makarov ¹

Alfiya R Mulyukova ¹

Dmitry S. Baev ³

Elza K. Khusnutdinova ⁴

Tatiana G. Tolstikova ³

Usein M. Dzhemilev ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Institute of Petrochemistry and Catalysis of Russian Academy of Sciences, Ufa, Russian Federation |

Department of Immunology and Human’s Reproductive Health, Bashkir State Medical University, Ufa, Russian Federation |

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation |

⁴

Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation |

Publication type: Journal Article

Publication date: 2015-09-15

Springer Nature

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR: 0.470

CiteScore: 5.1

Impact factor: 3.1

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-015-1446-1

Copy DOI

Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

Abstract

An original, effective approach to the stereoselective method for the synthesis of higher unsaturated acids containing a 1Z,5Z-diene group in 61–75 % yields and with >98 % selectivity based on the new intermolecular Cp2TiCl2-catalyzed cross-cyclomagnesiation of terminal aliphatic and O-containing 1,2-diene with Grignard reagents has been developed. The inhibitory action of the obtained dienoic acids on the human topoisomerase I and II was studied. Resorting to the data of molecular docking, a probable mechanism of inhibition was proposed.

Found

22 citations

Dzhemileva Lilya

🥼

DSc in Health sciences, associate professor

128 publications, 1 277 citations, 70 reviews

h-index: 21

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Institute of Physiologically Active Compounds of the Russian Academy of Science

Mendeleev University of Chemical Technology of Russia

Endocrinology Research Centre

1 citation

Padial Natalia

PhD, lecturer

62 publications, 2 477 citations, 8 reviews

h-index: 26

University of Valencia

Top-30

Journals

	1 2 3 4
Russian Journal of Organic Chemistry	Russian Journal of Organic Chemistry, 4, 9.52% Russian Journal of Organic Chemistry 4 publications, 9.52%
Mendeleev Communications	Mendeleev Communications, 3, 7.14% Mendeleev Communications 3 publications, 7.14%
ACS Omega	ACS Omega, 3, 7.14% ACS Omega 3 publications, 7.14%
Russian Chemical Bulletin	Russian Chemical Bulletin, 3, 7.14% Russian Chemical Bulletin 3 publications, 7.14%
Tetrahedron	Tetrahedron, 2, 4.76% Tetrahedron 2 publications, 4.76%
Bioorganic Chemistry	Bioorganic Chemistry, 2, 4.76% Bioorganic Chemistry 2 publications, 4.76%
Studies in Natural Products Chemistry	Studies in Natural Products Chemistry, 2, 4.76% Studies in Natural Products Chemistry 2 publications, 4.76%
Журнал органической химии	Журнал органической химии, 2, 4.76% Журнал органической химии 2 publications, 4.76%
Pharmaceuticals	Pharmaceuticals, 1, 2.38% Pharmaceuticals 1 publication, 2.38%
Cancers	Cancers, 1, 2.38% Cancers 1 publication, 2.38%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.38% International Journal of Molecular Sciences 1 publication, 2.38%
Phytochemistry Reviews	Phytochemistry Reviews, 1, 2.38% Phytochemistry Reviews 1 publication, 2.38%
Tetrahedron Letters	Tetrahedron Letters, 1, 2.38% Tetrahedron Letters 1 publication, 2.38%
Steroids	Steroids, 1, 2.38% Steroids 1 publication, 2.38%
European Journal of Organic Chemistry	European Journal of Organic Chemistry, 1, 2.38% European Journal of Organic Chemistry 1 publication, 2.38%
ChemistrySelect	ChemistrySelect, 1, 2.38% ChemistrySelect 1 publication, 2.38%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 2.38% Chemistry - A European Journal 1 publication, 2.38%
Journal of Natural Products	Journal of Natural Products, 1, 2.38% Journal of Natural Products 1 publication, 2.38%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 2.38% Organic and Biomolecular Chemistry 1 publication, 2.38%
Metallomics	Metallomics, 1, 2.38% Metallomics 1 publication, 2.38%
The 26th International Electronic Conference on Synthetic Organic Chemistry	The 26th International Electronic Conference on Synthetic Organic Chemistry, 1, 2.38% The 26th International Electronic Conference on Synthetic Organic Chemistry 1 publication, 2.38%
MolBank	MolBank, 1, 2.38% MolBank 1 publication, 2.38%
Doklady Chemistry	Doklady Chemistry, 1, 2.38% Doklady Chemistry 1 publication, 2.38%
Доклады Российской академии наук Химия науки о материалах	Доклады Российской академии наук Химия науки о материалах, 1, 2.38% Доклады Российской академии наук Химия науки о материалах 1 publication, 2.38%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.38% Russian Chemical Reviews 1 publication, 2.38%
	1 2 3 4

Publishers

	1 2 3 4 5 6 7 8 9
Elsevier	Elsevier, 9, 21.43% Elsevier 9 publications, 21.43%
MDPI	MDPI, 7, 16.67% MDPI 7 publications, 16.67%
Pleiades Publishing	Pleiades Publishing, 5, 11.9% Pleiades Publishing 5 publications, 11.9%
Springer Nature	Springer Nature, 4, 9.52% Springer Nature 4 publications, 9.52%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 9.52% American Chemical Society (ACS) 4 publications, 9.52%
OOO Zhurnal "Mendeleevskie Soobshcheniya"	OOO Zhurnal "Mendeleevskie Soobshcheniya", 3, 7.14% OOO Zhurnal "Mendeleevskie Soobshcheniya" 3 publications, 7.14%
Wiley	Wiley, 3, 7.14% Wiley 3 publications, 7.14%
Akademizdatcenter Nauka	Akademizdatcenter Nauka, 2, 4.76% Akademizdatcenter Nauka 2 publications, 4.76%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.38% Royal Society of Chemistry (RSC) 1 publication, 2.38%
Oxford University Press	Oxford University Press, 1, 2.38% Oxford University Press 1 publication, 2.38%
The Russian Academy of Sciences	The Russian Academy of Sciences, 1, 2.38% The Russian Academy of Sciences 1 publication, 2.38%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.38% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.38%
	1 2 3 4 5 6 7 8 9

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

D'yakonov V. A. et al. nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα // Medicinal Chemistry Research. 2015. Vol. 25. No. 1. pp. 30-39.

GOST all authors (up to 50) Copy

D'yakonov V. A., Dzhemileva L. U., Makarov A. A., Mulyukova A. R., Baev D. S., Khusnutdinova E. K., Tolstikova T. G., Dzhemilev U. M. nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα // Medicinal Chemistry Research. 2015. Vol. 25. No. 1. pp. 30-39.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1007/s00044-015-1446-1

UR - https://doi.org/10.1007/s00044-015-1446-1

TI - nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα

T2 - Medicinal Chemistry Research

AU - D'yakonov, Vladimir A.

AU - Dzhemileva, Lilya U.

AU - Makarov, Aleksey A

AU - Mulyukova, Alfiya R

AU - Baev, Dmitry S.

AU - Khusnutdinova, Elza K.

AU - Tolstikova, Tatiana G.

AU - Dzhemilev, Usein M.

PY - 2015

DA - 2015/09/15

PB - Springer Nature

SP - 30-39

IS - 1

VL - 25

SN - 1054-2523

SN - 1554-8120

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2015_D'yakonov,

author = {Vladimir A. D'yakonov and Lilya U. Dzhemileva and Aleksey A Makarov and Alfiya R Mulyukova and Dmitry S. Baev and Elza K. Khusnutdinova and Tatiana G. Tolstikova and Usein M. Dzhemilev},

title = {nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα},

journal = {Medicinal Chemistry Research},

year = {2015},

volume = {25},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1007/s00044-015-1446-1},

number = {1},

pages = {30--39},

doi = {10.1007/s00044-015-1446-1}

}

MLA

Cite this

MLA Copy

D'yakonov, Vladimir A., et al. “nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα.” Medicinal Chemistry Research, vol. 25, no. 1, Sep. 2015, pp. 30-39. https://doi.org/10.1007/s00044-015-1446-1.

Publisher

Springer Nature

Journal

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR

0.470

CiteScore

5.1

Impact factor

3.1

ISSN

10542523 (Print)

15548120 (Electronic)

Profiles