Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)
Publication type: Journal Article
Publication date: 2019-06-12
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
N-sulfonylamino azinones has attracted the interest of numerous researchers and extensive investigations on their biological activities have been done. The present review provides an overview of the patents and reports filed during the last few years pertaining to the synthesis N-sulfonyl azinones as well as their biological and preclinical studies. A brief discussion on the significant biological findings is also provided. It has been established that N-sulfonylamino azinones is privileged heterocycles possessing diuretic, antihypertensive, anti-inflammatory, and anticancer and other biological activities. In particular, a new generation of competitive AMPA receptor antagonist based on N-sulfonylamino 1H-quinazoline-2,4-diones is promising useful in the treatment neurological disorders such as epilepsy and schizophrenia. The scope of these new advances has been also highlighted in this review.
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58
Total citations:
58
Citations from 2025:
5
(8.62%)
The most citing journal
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6
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Elgemeie G. H., Azzam R. A., Elsayed R. E. Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018) // Medicinal Chemistry Research. 2019. Vol. 28. No. 8. pp. 1099-1131.
GOST all authors (up to 50)
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Elgemeie G. H., Azzam R. A., Elsayed R. E. Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018) // Medicinal Chemistry Research. 2019. Vol. 28. No. 8. pp. 1099-1131.
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TY - JOUR
DO - 10.1007/s00044-019-02378-6
UR - https://doi.org/10.1007/s00044-019-02378-6
TI - Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)
T2 - Medicinal Chemistry Research
AU - Elgemeie, Galal H.
AU - Azzam, Rasha A
AU - Elsayed, Rasha E.
PY - 2019
DA - 2019/06/12
PB - Springer Nature
SP - 1099-1131
IS - 8
VL - 28
SN - 1054-2523
SN - 1554-8120
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Elgemeie,
author = {Galal H. Elgemeie and Rasha A Azzam and Rasha E. Elsayed},
title = {Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)},
journal = {Medicinal Chemistry Research},
year = {2019},
volume = {28},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s00044-019-02378-6},
number = {8},
pages = {1099--1131},
doi = {10.1007/s00044-019-02378-6}
}
Cite this
MLA
Copy
Elgemeie, Galal H., et al. “Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018).” Medicinal Chemistry Research, vol. 28, no. 8, Jun. 2019, pp. 1099-1131. https://doi.org/10.1007/s00044-019-02378-6.