Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation
Ekaterina A. Nimenko
1
,
Radik R Shafikov
1, 2
,
Nikolay Y Zyk
1
,
Sergei A Evteev
3
,
Natalia S Dashkova
1
,
Yan A Ivanenkov
1, 3, 4, 5
,
Alexander G. Majouga
1, 4, 6
,
Aleksei E Machulkin
1
5
Publication type: Journal Article
Publication date: 2022-12-21
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
An improved series of ligands targeting prostatic specific membrane antigen has been reported. Varying compounds and their biological parameters were due to changes in the linker structure. Highly selective compounds with nanomolar IC50 values were obtained. As an example, a conjugate with Sulfo-Cy5 and MMAE was obtained and pre-studied.
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9
Total citations:
9
Citations from 2025:
4
(44.44%)
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GOST
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Uspenskaya A. A. et al. Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation // Medicinal Chemistry Research. 2022. Vol. 32. No. 1. pp. 32-37.
GOST all authors (up to 50)
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Uspenskaya A. A., Nimenko E. A., Shafikov R. R., Zyk N. Y., Evteev S. A., Dashkova N. S., Ivanenkov Y. A., Majouga A. G., Skvortsov D. A., Garanina A. S., Beloglazkina E. K., Machulkin A. E. Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation // Medicinal Chemistry Research. 2022. Vol. 32. No. 1. pp. 32-37.
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TY - JOUR
DO - 10.1007/s00044-022-03002-w
UR - https://link.springer.com/10.1007/s00044-022-03002-w
TI - Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation
T2 - Medicinal Chemistry Research
AU - Uspenskaya, Anastasia A.
AU - Nimenko, Ekaterina A.
AU - Shafikov, Radik R
AU - Zyk, Nikolay Y
AU - Evteev, Sergei A
AU - Dashkova, Natalia S
AU - Ivanenkov, Yan A
AU - Majouga, Alexander G.
AU - Skvortsov, Dmitry A.
AU - Garanina, Anastasiia S
AU - Beloglazkina, Elena K
AU - Machulkin, Aleksei E
PY - 2022
DA - 2022/12/21
PB - Springer Nature
SP - 32-37
IS - 1
VL - 32
SN - 1054-2523
SN - 1554-8120
ER -
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BibTex (up to 50 authors)
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@article{2022_Uspenskaya,
author = {Anastasia A. Uspenskaya and Ekaterina A. Nimenko and Radik R Shafikov and Nikolay Y Zyk and Sergei A Evteev and Natalia S Dashkova and Yan A Ivanenkov and Alexander G. Majouga and Dmitry A. Skvortsov and Anastasiia S Garanina and Elena K Beloglazkina and Aleksei E Machulkin},
title = {Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation},
journal = {Medicinal Chemistry Research},
year = {2022},
volume = {32},
publisher = {Springer Nature},
month = {dec},
url = {https://link.springer.com/10.1007/s00044-022-03002-w},
number = {1},
pages = {32--37},
doi = {10.1007/s00044-022-03002-w}
}
Cite this
MLA
Copy
Uspenskaya, Anastasia A., et al. “Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation.” Medicinal Chemistry Research, vol. 32, no. 1, Dec. 2022, pp. 32-37. https://link.springer.com/10.1007/s00044-022-03002-w.