Journal of Cancer Research and Clinical Oncology, volume 147, issue 1, pages 49-59

Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors

Lazarevich Natalia L. 2, 3
Kustova Inna F. 2
Shavochkina Daria A 2
Moroz Ekaterina A. 4
Kudashkin Nikolay E. 4
Patyutko Yuriy I 4
Metelin Alexey V 5
Kim Eduard F 5
Zatsepin Timofei S 1, 7
Rubtsova Maria P 1, 7
Publication typeJournal Article
Publication date2020-09-12
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor3.6
ISSN01715216, 14321335
Cancer Research
Oncology
General Medicine
Abstract
Purpose Liver cancers are among the deadliest malignancies due to a limited efficacy of early diagnostics, the lack of appropriate biomarkers and insufficient discrimination of different types of tumors by classic and molecular methods. In this study, we searched for novel long non-coding RNA (lncRNA) as well as validated several known candidates suitable as probable biomarkers for primary liver tumors of various etiology. Methods We described a novel lncRNA HELIS (aka “HEalthy LIver Specific”) and estimated its expression by RT-qPCR in 82 paired tissue samples from patients with hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), combined HCC-CCA, pediatric hepatoblastoma (HBL) and non-malignant hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH). Additionally, we examined expression of cancer-associated lncRNAs HULC, MALAT1, UCA1, CYTOR, LINC01093 and H19, which were previously studied mainly in HCC. Results We demonstrated that down-regulation of HELIS strongly correlates with carcinogenesis; whereas in tumors with non-hepatocyte origin (HBL, CCA) or in a number of poorly differentiated HCC, this lncRNA is not expressed. We showed that recently discovered LINC01093 is dramatically down-regulated in all malignant liver cancers; while in benign tumors LINC01093 expression is just twice decreased in comparison to adjacent samples. Conclusion Our study revealed that among all measured biomarkers only down-regulated HELIS and LINC01093, up-regulated CYTOR and dysregulated HULC are perspective for differential diagnostics of liver cancers; whereas others demonstrated discordant results and cannot be considered as potential universal biomarkers for this purpose.

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Burenina O. Y. et al. Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors // Journal of Cancer Research and Clinical Oncology. 2020. Vol. 147. No. 1. pp. 49-59.
GOST all authors (up to 50) Copy
Burenina O. Y., Lazarevich N. L., Kustova I. F., Shavochkina D. A., Moroz E. A., Kudashkin N. E., Patyutko Y. I., Metelin A. V., Kim E. F., Skvortsov D. A., Zatsepin T. S., Rubtsova M. P., Dontsova O. A. Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors // Journal of Cancer Research and Clinical Oncology. 2020. Vol. 147. No. 1. pp. 49-59.
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TY - JOUR
DO - 10.1007/s00432-020-03378-5
UR - https://doi.org/10.1007%2Fs00432-020-03378-5
TI - Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors
T2 - Journal of Cancer Research and Clinical Oncology
AU - Burenina, Olga Y
AU - Lazarevich, Natalia L.
AU - Kustova, Inna F.
AU - Shavochkina, Daria A
AU - Moroz, Ekaterina A.
AU - Kudashkin, Nikolay E.
AU - Patyutko, Yuriy I
AU - Metelin, Alexey V
AU - Kim, Eduard F
AU - Skvortsov, Dmitry A.
AU - Zatsepin, Timofei S
AU - Rubtsova, Maria P
AU - Dontsova, Olga A.
PY - 2020
DA - 2020/09/12 00:00:00
PB - Springer Nature
SP - 49-59
IS - 1
VL - 147
SN - 0171-5216
SN - 1432-1335
ER -
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@article{2020_Burenina
author = {Olga Y Burenina and Natalia L. Lazarevich and Inna F. Kustova and Daria A Shavochkina and Ekaterina A. Moroz and Nikolay E. Kudashkin and Yuriy I Patyutko and Alexey V Metelin and Eduard F Kim and Dmitry A. Skvortsov and Timofei S Zatsepin and Maria P Rubtsova and Olga A. Dontsova},
title = {Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors},
journal = {Journal of Cancer Research and Clinical Oncology},
year = {2020},
volume = {147},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007%2Fs00432-020-03378-5},
number = {1},
pages = {49--59},
doi = {10.1007/s00432-020-03378-5}
}
MLA
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MLA Copy
Burenina, Olga Y., et al. “Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors.” Journal of Cancer Research and Clinical Oncology, vol. 147, no. 1, Sep. 2020, pp. 49-59. https://doi.org/10.1007%2Fs00432-020-03378-5.
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