Bulletin of Experimental Biology and Medicine, volume 160, issue 6, pages 835-839
Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis
Postovalova E A
1, 2
,
Khochansky D N
2
,
Zolotova N A
1, 2
,
Gao Yu
1
,
Makarova O. V.
1, 2
,
Dobrynina M T
1
Publication type: Journal Article
Publication date: 2016-04-01
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Morphological changes in the mesenteric lymph nodes of male C57Bl/6 mice and subpopulation composition of lymphocytes in these nodes were studied in experimental acute and chronic ulcerative colitis induced by sodium dextran sulfate. Acute and chronic ulcerative colitis was associated with the development of reactive changes in the mesenteric lymph nodes. These changes were of mixed type and were characterized by follicular hyperplasia and sinus reaction. The content of CD19+ B cells in the mesenteric lymph nodes decreased in acute ulcerative colitis, while the content of CD3+CD8+ cytotoxic T cells increased, which presumably reflected activation of Th1 reactions. The increase in the count of CD4+CD25+FOXP3+ regulatory T cells and CD3+CD8+ cytotoxic T cells was due to intensive migration of lymphocytes from the thymus and the colonic compartment of the local immune system. Chronic ulcerative colitis was associated with higher levels of CD19+ B cells and CD3+CD4+ T helper cells in the mesenteric lymph nodes, which was characteristic of adoptive immunity reactions and chronization of the inflammatory process.
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Postovalova E. A. et al. Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis // Bulletin of Experimental Biology and Medicine. 2016. Vol. 160. No. 6. pp. 835-839.
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Postovalova E. A., Khochansky D. N., Zolotova N. A., Gao Yu., Makarova O. V., Dobrynina M. T. Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis // Bulletin of Experimental Biology and Medicine. 2016. Vol. 160. No. 6. pp. 835-839.
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TY - JOUR
DO - 10.1007/s10517-016-3322-5
UR - https://doi.org/10.1007%2Fs10517-016-3322-5
TI - Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis
T2 - Bulletin of Experimental Biology and Medicine
AU - Khochansky, D N
AU - Zolotova, N A
AU - Gao, Yu
AU - Dobrynina, M T
AU - Makarova, O. V.
AU - Postovalova, E A
PY - 2016
DA - 2016/04/01 00:00:00
PB - Springer Nature
SP - 835-839
IS - 6
VL - 160
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2016_Postovalova,
author = {D N Khochansky and N A Zolotova and Yu Gao and M T Dobrynina and O. V. Makarova and E A Postovalova},
title = {Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2016},
volume = {160},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs10517-016-3322-5},
number = {6},
pages = {835--839},
doi = {10.1007/s10517-016-3322-5}
}
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Postovalova, E. A., et al. “Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis.” Bulletin of Experimental Biology and Medicine, vol. 160, no. 6, Apr. 2016, pp. 835-839. https://doi.org/10.1007%2Fs10517-016-3322-5.