Bulletin of Experimental Biology and Medicine

, том 160 , издание 6 , страницы 835-839

Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis

E A Postovalova ^{1, 2}

D N Khochansky ²

N A Zolotova ^{1, 2}

Yu Gao ¹

O. V. Makarova ^{1, 2}

M T Dobrynina ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 2 аффилиации

Department of Cellular Biology and Histology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |

Institute of Human Morphology, Moscow, Russia |

Тип публикации: Journal Article

Дата публикации: 2016-04-01

Springer Nature

Bulletin of Experimental Biology and Medicine

Включен в RSCI

scimago Q3

wos Q4

БС2

SJR: 0.277

CiteScore: 1.5

Impact factor: 0.6

ISSN: 00074888, 15738221, 03659615, 24131008

DOI: 10.1007/s10517-016-3322-5

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PubMed ID: 27165070

General Biochemistry, Genetics and Molecular Biology

General Medicine

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Morphological changes in the mesenteric lymph nodes of male C57Bl/6 mice and subpopulation composition of lymphocytes in these nodes were studied in experimental acute and chronic ulcerative colitis induced by sodium dextran sulfate. Acute and chronic ulcerative colitis was associated with the development of reactive changes in the mesenteric lymph nodes. These changes were of mixed type and were characterized by follicular hyperplasia and sinus reaction. The content of CD19+ B cells in the mesenteric lymph nodes decreased in acute ulcerative colitis, while the content of CD3+CD8+ cytotoxic T cells increased, which presumably reflected activation of Th1 reactions. The increase in the count of CD4+CD25+FOXP3+ regulatory T cells and CD3+CD8+ cytotoxic T cells was due to intensive migration of lymphocytes from the thymus and the colonic compartment of the local immune system. Chronic ulcerative colitis was associated with higher levels of CD19+ B cells and CD3+CD4+ T helper cells in the mesenteric lymph nodes, which was characteristic of adoptive immunity reactions and chronization of the inflammatory process.

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Postovalova E. A. et al. Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis // Bulletin of Experimental Biology and Medicine. 2016. Vol. 160. No. 6. pp. 835-839.

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Postovalova E. A., Khochansky D. N., Zolotova N. A., Gao Yu., Makarova O. V., Dobrynina M. T. Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis // Bulletin of Experimental Biology and Medicine. 2016. Vol. 160. No. 6. pp. 835-839.

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TY - JOUR

DO - 10.1007/s10517-016-3322-5

UR - https://doi.org/10.1007/s10517-016-3322-5

TI - Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis

T2 - Bulletin of Experimental Biology and Medicine

AU - Postovalova, E A

AU - Khochansky, D N

AU - Zolotova, N A

AU - Gao, Yu

AU - Makarova, O. V.

AU - Dobrynina, M T

PY - 2016

DA - 2016/04/01

PB - Springer Nature

SP - 835-839

IS - 6

VL - 160

PMID - 27165070

SN - 0007-4888

SN - 1573-8221

SN - 0365-9615

SN - 2413-1008

ER -

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@article{2016_Postovalova,

author = {E A Postovalova and D N Khochansky and N A Zolotova and Yu Gao and O. V. Makarova and M T Dobrynina},

title = {Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis},

journal = {Bulletin of Experimental Biology and Medicine},

year = {2016},

volume = {160},

publisher = {Springer Nature},

month = {apr},

url = {https://doi.org/10.1007/s10517-016-3322-5},

number = {6},

pages = {835--839},

doi = {10.1007/s10517-016-3322-5}

}

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Postovalova, E. A., et al. “Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis.” Bulletin of Experimental Biology and Medicine, vol. 160, no. 6, Apr. 2016, pp. 835-839. https://doi.org/10.1007/s10517-016-3322-5.