Laboratory of Immunomorphology of Inflammation
Publications
115
Citations
2 460
h-index
25
Authorization required.
The laboratory was established in 1999. The scientific direction of the laboratory is the study of cellular and molecular mechanisms of inflammatory and immune response depending on gender, age, and the body's resistance to hypoxia.
Methods: microscopy, description of histological preparations, PCR, IHC, ELISA, flow cytofluorimetry, cultural methods.
Experimental models: acute and chronic ulcerative colitis, systemic inflammatory response, colon cancer, chronic prostatitis, glioblastoma, melanoma, cold stress, in vivo and in vitro hypoxia modeling.
- Real-time PCR (qPCR)
- Flow cytometry
- Morphometry
- Fluorescence microscopy
- Immunohistochemistry (IHC)
- Histochemistry
- Cell and tissue culture
- Enzyme-linked immunosorbent assay (ELISA)
Research directions
Morphofunctional features of colon cancer depending on initial resistance to hypoxia
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The severity of the course of many diseases, including tumor ones, depends on the initial resistance of the body to hypoxia, which is not taken into account during therapy. Our work investigates the mechanisms of colon cancer in animals with different resistance to hypoxia.
The contribution of microplastic particle consumption to the development of inflammatory bowel diseases
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Environmental pollution by microplastics is a global problem that has arisen due to the extensive production and use of plastic. Our work evaluates the ability of microplastics to induce inflammatory reactions in the colon and exacerbate the pathological process in colitis, which will allow for the first time to give an objective assessment of the risk of environmental pollution and food for human health.
Features of systemic inflammatory response in animals with different resistance to hypoxia
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It is known that organisms differ in their resistance to hypoxia and in the severity of the course of a systemic inflammatory reaction. This is largely due to the different levels of HIF-1 protein, which causes a reaction to hypoxic effects. In our work, the mechanisms of the course of a systemic inflammatory reaction in animals with different resistance to hypoxia are investigated.
Publications and patents
2023
—
2024
| Джалилова Джулия Шавкатовна
2022
—
2023
| Золотова Наталья Александровна
Partners
Lab address
Москва, ул. Цюрупы, д.3
Authorization required.