Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis
Publication type: Journal Article
Publication date: 2018-08-19
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
30123951
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
We studied changes in the expression of mRNA for mucins and claudins in the medial part of the colon in male C57Bl/6 mice on the model of acute and chronic colitis induced by substitution of drinking water with 1% solution of dextran sodium sulphate for 5 days. In acute colitis, the expression of the main structural component of glycocalyx, mucin Muc3, decreased and expression of pore-forming claudin Cldn2 increased, which reflected enhanced permeability of tight junctions. In the chronic colitis group, in comparison with the normal group, we observed an increase in expression of mRNA of main structural mucus component Muc2, enhanced of expression of Muc1 associated with carcinogenesis, and reduced expression of Muc13, which led to a more severe course of colitis; the expression of pore-forming claudin Cldn2 was elevated. These findings indicate that the imbalance in the expression of mucins and claudins plays an important role in the mechanisms of development of acute and chronic colitis.
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Zolotova N. A. et al. Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis // Bulletin of Experimental Biology and Medicine. 2018. Vol. 165. No. 4. pp. 434-437.
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Zolotova N. A., Polikarpova A. V., Khochanskii D. N., Makarova O. V., Mikhailova L. P. Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis // Bulletin of Experimental Biology and Medicine. 2018. Vol. 165. No. 4. pp. 434-437.
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TY - JOUR
DO - 10.1007/s10517-018-4187-6
UR - https://doi.org/10.1007/s10517-018-4187-6
TI - Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis
T2 - Bulletin of Experimental Biology and Medicine
AU - Zolotova, N A
AU - Polikarpova, A V
AU - Khochanskii, D N
AU - Makarova, O. V.
AU - Mikhailova, L P
PY - 2018
DA - 2018/08/19
PB - Springer Nature
SP - 434-437
IS - 4
VL - 165
PMID - 30123951
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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BibTex (up to 50 authors)
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@article{2018_Zolotova,
author = {N A Zolotova and A V Polikarpova and D N Khochanskii and O. V. Makarova and L P Mikhailova},
title = {Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2018},
volume = {165},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s10517-018-4187-6},
number = {4},
pages = {434--437},
doi = {10.1007/s10517-018-4187-6}
}
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MLA
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Zolotova, N. A., et al. “Expression of Mucins and Claudins in the Colon during Acute and Chronic Experimental Colitis.” Bulletin of Experimental Biology and Medicine, vol. 165, no. 4, Aug. 2018, pp. 434-437. https://doi.org/10.1007/s10517-018-4187-6.