Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia
Publication type: Journal Article
Publication date: 2018-10-23
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
30353332
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
We studied the expression of Hif-1α, Nf-κb, and Vegf genes in the liver and serum levels of HIF-1α, erythropoietin, VEGF, TGF-β, 8-isoprostane, and corticosterone in Wistar rats with different resistance to hypoxia in 5 and 90 min after acute exposure to hypobaric hypoxia. In 5 min after hypoxic exposure, Hif-1α expression in the liver and serum levels of erythropoietin, VEGF, and TGF-β in high-resistant rats were higher than in low-resistant animals. In highresistant rats, the increment in expression of Nf-κb gene responsible for the control over the inflammatory processes was more pronounced than in low-resistant animals. In 90 min after hypoxic exposure, the serum levels of HIF-1α, erythropoietin, VEGF, and TGF-β returned to normal in high-resistant rats, while in low-resistant animals, an increase in 8-isoprostane and TGF-β concentrations was observed. The rats with different resistance to hypoxia were characterized by different changes in biomolecular parameters determining predilection to inflammatory diseases.
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Dzhalilova D. S. et al. Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia // Bulletin of Experimental Biology and Medicine. 2018. Vol. 165. No. 6. pp. 781-785.
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Dzhalilova D. S., Diatroptov M. E., Tsvetkov I. S., Makarova O. V., Kuznetsov S. L. Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia // Bulletin of Experimental Biology and Medicine. 2018. Vol. 165. No. 6. pp. 781-785.
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TY - JOUR
DO - 10.1007/s10517-018-4264-x
UR - https://doi.org/10.1007/s10517-018-4264-x
TI - Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia
T2 - Bulletin of Experimental Biology and Medicine
AU - Dzhalilova, D S
AU - Diatroptov, M E
AU - Tsvetkov, I S
AU - Makarova, O. V.
AU - Kuznetsov, S. L.
PY - 2018
DA - 2018/10/23
PB - Springer Nature
SP - 781-785
IS - 6
VL - 165
PMID - 30353332
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2018_Dzhalilova,
author = {D S Dzhalilova and M E Diatroptov and I S Tsvetkov and O. V. Makarova and S. L. Kuznetsov},
title = {Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2018},
volume = {165},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s10517-018-4264-x},
number = {6},
pages = {781--785},
doi = {10.1007/s10517-018-4264-x}
}
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MLA
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Dzhalilova, D. S., et al. “Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia.” Bulletin of Experimental Biology and Medicine, vol. 165, no. 6, Oct. 2018, pp. 781-785. https://doi.org/10.1007/s10517-018-4264-x.