Bulletin of Experimental Biology and Medicine, volume 168, issue 3, pages 390-394
Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia
Fridman I A
1
,
Ponomarenko E A
1
,
Makarova O. V.
1
,
Postovalova E A
1
,
Zolotova N A
1
,
Khochanskiy D N
1
,
Mkhitarov V A
1
,
Tsvetkov I S
1
,
Publication type: Journal Article
Publication date: 2020-01-15
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
The features of B16 melanoma progression in male C57BL/6 mice with initially high and low resistance to hypoxia were studied. To assess the resistance to hypoxia, the mice were placed in a low-pressure chamber at a simulated altitude of 10,000 m. One month after testing, B16 melanoma was inoculated to high- and low-resistant animals. In 19 days after melanoma transplantation, the severity of melanoma progression was assessed by morphological and immunofluorescent methods. The expression of vegf-a and hif-1a in the liver of melanomabearing and control mice was evaluated by real-time PCR. Tumor growth progression was more pronounced in low-resistant mice, which was seen from high weight of the primary tumor node, relative necrosis area, proliferation rates (mitotic index and number of Ki-67+ cells), and expression of vegf-a gene in the liver. In high-resistant to hypoxia animals, the number of caspase-3+ cells dying by apoptosis was higher. The data on more rapid melanoma progression in mice with low resistance to hypoxia should be considered during the search of new prognostic markers and methods for therapy of malignant neoplasms.
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Fridman I. A. et al. Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia // Bulletin of Experimental Biology and Medicine. 2020. Vol. 168. No. 3. pp. 390-394.
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Fridman I. A., Ponomarenko E. A., Makarova O. V., Postovalova E. A., Zolotova N. A., Khochanskiy D. N., Mkhitarov V. A., Tsvetkov I. S., Kosyreva A. M. Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia // Bulletin of Experimental Biology and Medicine. 2020. Vol. 168. No. 3. pp. 390-394.
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TY - JOUR
DO - 10.1007/s10517-020-04716-w
UR - https://doi.org/10.1007%2Fs10517-020-04716-w
TI - Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia
T2 - Bulletin of Experimental Biology and Medicine
AU - Fridman, I A
AU - Ponomarenko, E A
AU - Zolotova, N A
AU - Khochanskiy, D N
AU - Mkhitarov, V A
AU - Tsvetkov, I S
AU - Kosyreva, A M
AU - Makarova, O. V.
AU - Postovalova, E A
PY - 2020
DA - 2020/01/15 00:00:00
PB - Springer Nature
SP - 390-394
IS - 3
VL - 168
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2020_Fridman,
author = {I A Fridman and E A Ponomarenko and N A Zolotova and D N Khochanskiy and V A Mkhitarov and I S Tsvetkov and A M Kosyreva and O. V. Makarova and E A Postovalova},
title = {Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2020},
volume = {168},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007%2Fs10517-020-04716-w},
number = {3},
pages = {390--394},
doi = {10.1007/s10517-020-04716-w}
}
Cite this
MLA
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Fridman, I. A., et al. “Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to Hypoxia.” Bulletin of Experimental Biology and Medicine, vol. 168, no. 3, Jan. 2020, pp. 390-394. https://doi.org/10.1007%2Fs10517-020-04716-w.