Springer Nature
Bulletin of Experimental Biology and Medicine
,  volume 169 ,  issue 1 ,  pages 104-109

Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis

Publication type: Journal Article
Publication date: 2020-05-01
Springer Nature
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Morphological, morphometric, and ultrastructural analysis of the nerve fibers in the colon mucosa was performed in C57BL/6 mice at various terms of development of acute colitis induced by dextran sodium sulphate. The nerve fibers were labeled with antibodies to pan-neuronal marker βIII-tubulin. The progression of inflammatory and ulcerative processes in the mucosa on days 3-5 was associated with hyperplasia and hypertrophy of nerve fibers that peaked on day 7 after colitis induction. Ultrastructural analysis at all terms of colitis development showed moderate degeneration of axons. Thus, hypertrophy and hyperplasia of the nervous fibers in colon mucosa in experimental acute colitis correlated with aggravation of the ulcerative process in the mucosa. These changes are determined by alteration of histoarchitectonics and regenerative processes in the mucosa.
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Khochanskiy D. N. et al. Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 1. pp. 104-109.
GOST all authors (up to 50) Copy
Khochanskiy D. N., Mkhitarov V. A., Sladkopevtsev A. S., Chernikov V. P., Mikhailova L. P., Dobrynina M. T., Makarova O. V. Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 1. pp. 104-109.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s10517-020-04834-5
UR - https://doi.org/10.1007/s10517-020-04834-5
TI - Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis
T2 - Bulletin of Experimental Biology and Medicine
AU - Khochanskiy, D N
AU - Mkhitarov, V A
AU - Sladkopevtsev, A S
AU - Chernikov, V P
AU - Mikhailova, L P
AU - Dobrynina, M T
AU - Makarova, O. V.
PY - 2020
DA - 2020/05/01
PB - Springer Nature
SP - 104-109
IS - 1
VL - 169
PMID - 32488782
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Khochanskiy,
author = {D N Khochanskiy and V A Mkhitarov and A S Sladkopevtsev and V P Chernikov and L P Mikhailova and M T Dobrynina and O. V. Makarova},
title = {Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2020},
volume = {169},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s10517-020-04834-5},
number = {1},
pages = {104--109},
doi = {10.1007/s10517-020-04834-5}
}
MLA
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MLA Copy
Khochanskiy, D. N., et al. “Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis.” Bulletin of Experimental Biology and Medicine, vol. 169, no. 1, May. 2020, pp. 104-109. https://doi.org/10.1007/s10517-020-04834-5.