Bulletin of Experimental Biology and Medicine, volume 169, issue 6, pages 825-830
Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance.
Dzhalilova D Sh
1
,
Kosyreva A M
1
,
Tsvetkov I S
1
,
Zolotova N A
1
,
Mkhitarov V A
1
,
Mikhailova L P
1
,
Publication type: Journal Article
Publication date: 2020-10-24
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
The morphological and functional peculiarities of the immune system are studied in adult male and female Wistar rats with high and low hypoxic resistance. Sex-specific differences in the subpopulation composition of the peripheral blood lymphocytes, not depending on the hypoxic resistance of animals, are detected: the males have lower absolute counts of T helpers and higher percentage of regulatory T cells than the females in the diestrus phase. Comparison of the morphofunctional status of the immune system in male and female (diestrus) rats with high resistance to hypoxia has shown a better developed subcapsular zone of the thymus, higher levels of anti-inflammatory cytokine TGF-β, and lower absolute counts of cytotoxic T lymphocytes in the peripheral blood in the males. Males with low hypoxic resistance have higher counts of phase II thymic bodies in comparison with low-resistant females. Hence, morphofunctional differences in the immune system of male and female rats with different hypoxic resistance are detected, which can determine the course of inflammatory diseases.
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Multidisciplinary Digital Publishing Institute (MDPI)
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Dzhalilova D. S. et al. Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance. // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 6. pp. 825-830.
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Dzhalilova D. S., Kosyreva A. M., Tsvetkov I. S., Zolotova N. A., Mkhitarov V. A., Mikhailova L. P., Makarova O. V. Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance. // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 6. pp. 825-830.
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TY - JOUR
DO - 10.1007/s10517-020-04989-1
UR - https://doi.org/10.1007%2Fs10517-020-04989-1
TI - Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance.
T2 - Bulletin of Experimental Biology and Medicine
AU - Dzhalilova, D Sh
AU - Kosyreva, A M
AU - Tsvetkov, I S
AU - Zolotova, N A
AU - Mkhitarov, V A
AU - Mikhailova, L P
AU - Makarova, O. V.
PY - 2020
DA - 2020/10/24 00:00:00
PB - Springer Nature
SP - 825-830
IS - 6
VL - 169
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2020_Dzhalilova,
author = {D Sh Dzhalilova and A M Kosyreva and I S Tsvetkov and N A Zolotova and V A Mkhitarov and L P Mikhailova and O. V. Makarova},
title = {Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance.},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2020},
volume = {169},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007%2Fs10517-020-04989-1},
number = {6},
pages = {825--830},
doi = {10.1007/s10517-020-04989-1}
}
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Dzhalilova, D. Sh, et al. “Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance..” Bulletin of Experimental Biology and Medicine, vol. 169, no. 6, Oct. 2020, pp. 825-830. https://doi.org/10.1007%2Fs10517-020-04989-1.