Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction
Alexander Barashkin
1
,
Vladislav Polyakov
1
,
German Kotovsky
1
,
Nikita Karpov
1
,
Sofia Mefedova
1
,
Bogdan Zagribelny
1, 2
,
Yan Ivanenkov
2
,
Marina Kalinina
3
,
Dmitry Skvortsov
1, 4
,
Victor Tafeenko
1
,
Nikolay Zyk
1
,
Alexander Majouga
1, 5, 6
,
Тип публикации: Journal Article
Дата публикации: 2020-06-01
scimago Q4
wos Q4
БС3
SJR: 0.243
CiteScore: 2.7
Impact factor: 1.0
ISSN: 00093122, 15738353
Organic Chemistry
Краткое описание
A series of novel hydantoin-based dispiroindolinones as potential small-molecule inhibitors of p53–MDM2 protein–protein interaction were synthesized by two methods, using 2-arylidenehydantoins as starting materials. Some compounds demonstrate moderate cytotoxicity against cancer cell lines with IC50 in micromolar concentration range, which is comparable to nutlin-3. Two of the synthesized dispiroindolinones show p53-related activity in p53 reporter activation test.
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Beloglazkina A. et al. Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 747-755.
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Beloglazkina A., Barashkin A., Polyakov V., Kotovsky G., Karpov N., Mefedova S., Zagribelny B., Ivanenkov Y., Kalinina M., Skvortsov D., Tafeenko V., Zyk N., Majouga A., Beloglazkina E. Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 747-755.
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TY - JOUR
DO - 10.1007/s10593-020-02726-0
UR - https://link.springer.com/10.1007/s10593-020-02726-0
TI - Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction
T2 - Chemistry of Heterocyclic Compounds
AU - Beloglazkina, Anastasia
AU - Barashkin, Alexander
AU - Polyakov, Vladislav
AU - Kotovsky, German
AU - Karpov, Nikita
AU - Mefedova, Sofia
AU - Zagribelny, Bogdan
AU - Ivanenkov, Yan
AU - Kalinina, Marina
AU - Skvortsov, Dmitry
AU - Tafeenko, Victor
AU - Zyk, Nikolay
AU - Majouga, Alexander
AU - Beloglazkina, Elena
PY - 2020
DA - 2020/06/01
PB - Springer Nature
SP - 747-755
IS - 6
VL - 56
SN - 0009-3122
SN - 1573-8353
ER -
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@article{2020_Beloglazkina,
author = {Anastasia Beloglazkina and Alexander Barashkin and Vladislav Polyakov and German Kotovsky and Nikita Karpov and Sofia Mefedova and Bogdan Zagribelny and Yan Ivanenkov and Marina Kalinina and Dmitry Skvortsov and Victor Tafeenko and Nikolay Zyk and Alexander Majouga and Elena Beloglazkina},
title = {Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction},
journal = {Chemistry of Heterocyclic Compounds},
year = {2020},
volume = {56},
publisher = {Springer Nature},
month = {jun},
url = {https://link.springer.com/10.1007/s10593-020-02726-0},
number = {6},
pages = {747--755},
doi = {10.1007/s10593-020-02726-0}
}
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MLA
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Beloglazkina, Anastasia, et al. “Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction.” Chemistry of Heterocyclic Compounds, vol. 56, no. 6, Jun. 2020, pp. 747-755. https://link.springer.com/10.1007/s10593-020-02726-0.