Journal of Computational Neuroscience, volume 39, issue 1, pages 1-16
Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations
Publication type: Journal Article
Publication date: 2015-04-24
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 1.2
ISSN: 09295313, 15736873
Cellular and Molecular Neuroscience
Cognitive Neuroscience
Sensory Systems
Abstract
It is widely believed that the theta rhythm in the hippocampus is caused by the rhythmic input from the medial septum-diagonal band of Broca (MSDB). The main MSDB output is formed by GABAergic projection neurons which are divided into two subpopulations and fire at different phases of the hippocampal theta rhythm. The MSDB also contains projection cholinergic, glutamatergic, and non-projection GABAergic neurons. These cell populations innervate each other and also GABAergic projection neurons and participate in the formation of the synchronous rhythmic output to the hippocampus. The purpose of this study is to work out a model of interactions between all neural populations of the MSDB that underlie the formation of the synchronous septal theta signal. The model is built from biologically plausible neurons of the Hodgkin-Huxley type and its architecture reflects modern data on the morphology of neural connections in the MSDB. The model satisfies the following requirements: (1) a large portion of neurons is fast-spiking; (2) the subpopulations of GABAergic projection neurons contain endogenous pacemaker neurons; (3) the phase shift of activity between subpopulations of GABAergic projection neurons is equal to about 150°; and (4) the strengths of bidirectional connections between the subpopulations of GABAergic projection cells are different. It is shown that the theta rhythm generation can be performed by a system of glutamatergic and GABAergic non-projection neurons. We also show that bursting pacemaker neurons in the subpopulation of projection GABAergic neurons play a significant role in the formation of stable antiphase outputs from the MSDB to the hippocampus.
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Citations by publishers
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Elsevier
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3 publications, 25%
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3 publications, 25%
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Frontiers Media S.A.
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1 publication, 8.33%
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1
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mysin I., Kitchigina V. F., Kazanovich Y. Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations // Journal of Computational Neuroscience. 2015. Vol. 39. No. 1. pp. 1-16.
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Mysin I., Kitchigina V. F., Kazanovich Y. Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations // Journal of Computational Neuroscience. 2015. Vol. 39. No. 1. pp. 1-16.
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TY - JOUR
DO - 10.1007/s10827-015-0564-6
UR - https://doi.org/10.1007%2Fs10827-015-0564-6
TI - Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations
T2 - Journal of Computational Neuroscience
AU - Mysin, Ivan
AU - Kitchigina, Valentina F
AU - Kazanovich, Yakov
PY - 2015
DA - 2015/04/24 00:00:00
PB - Springer Nature
SP - 1-16
IS - 1
VL - 39
SN - 0929-5313
SN - 1573-6873
ER -
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@article{2015_Mysin,
author = {Ivan Mysin and Valentina F Kitchigina and Yakov Kazanovich},
title = {Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations},
journal = {Journal of Computational Neuroscience},
year = {2015},
volume = {39},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs10827-015-0564-6},
number = {1},
pages = {1--16},
doi = {10.1007/s10827-015-0564-6}
}
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Mysin, Ivan, et al. “Modeling synchronous theta activity in the medial septum: key role of local communications between different cell populations.” Journal of Computational Neuroscience, vol. 39, no. 1, Apr. 2015, pp. 1-16. https://doi.org/10.1007%2Fs10827-015-0564-6.