Tetrazoles as carboxylic acid isosteres: chemistry and biology
Publication type: Journal Article
Publication date: 2013-05-24
scimago Q3
wos Q3
SJR: 0.364
CiteScore: 3.7
Impact factor: 1.6
ISSN: 13883127, 15731111, 09230750
General Chemistry
Condensed Matter Physics
Food Science
Abstract
Tetrazoles are often used as metabolism-resistant isosteric replacements for carboxylic acids in SAR-driven medicinal chemistry analogue syntheses. Tetrazoles have not been found in nature; with rare exceptions, these compounds do not exhibit appreciable biological activity, but they are at the same time resistant to biological degradation. This property makes it possible to use tetrazoles as isosteric substituents of various functional groups in the development of biologically active substances. The tetrazole motif has been used in various drug pharmacophores as a suitable replacement of carboxylic acid moiety and different methods have been used for the synthesis of tetrazoles using different reaction conditions. This review tries to give a vivid look on the different synthetic methods, using catalysts or different reagents for the synthesis of tetrazoles. The biological importance of tetrazoles has also been highlighted.
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112
Total citations:
112
Citations from 2025:
9
(8.04%)
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GOST
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Malik M. A. et al. Tetrazoles as carboxylic acid isosteres: chemistry and biology // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2013. Vol. 78. No. 1-4. pp. 15-37.
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Malik M. A., Wani M. Y., Al-Thabaiti S. A., Shiekh R. A. Tetrazoles as carboxylic acid isosteres: chemistry and biology // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2013. Vol. 78. No. 1-4. pp. 15-37.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s10847-013-0334-x
UR - https://doi.org/10.1007/s10847-013-0334-x
TI - Tetrazoles as carboxylic acid isosteres: chemistry and biology
T2 - Journal of Inclusion Phenomena and Macrocyclic Chemistry
AU - Malik, Maqsood Ahmad
AU - Wani, Mohmmad Younus
AU - Al-Thabaiti, Shaeel Ahmed
AU - Shiekh, Rayees Ahmad
PY - 2013
DA - 2013/05/24
PB - Springer Nature
SP - 15-37
IS - 1-4
VL - 78
SN - 1388-3127
SN - 1573-1111
SN - 0923-0750
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Malik,
author = {Maqsood Ahmad Malik and Mohmmad Younus Wani and Shaeel Ahmed Al-Thabaiti and Rayees Ahmad Shiekh},
title = {Tetrazoles as carboxylic acid isosteres: chemistry and biology},
journal = {Journal of Inclusion Phenomena and Macrocyclic Chemistry},
year = {2013},
volume = {78},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s10847-013-0334-x},
number = {1-4},
pages = {15--37},
doi = {10.1007/s10847-013-0334-x}
}
Cite this
MLA
Copy
Malik, Maqsood Ahmad, et al. “Tetrazoles as carboxylic acid isosteres: chemistry and biology.” Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 78, no. 1-4, May. 2013, pp. 15-37. https://doi.org/10.1007/s10847-013-0334-x.