Journal of Inclusion Phenomena and Macrocyclic Chemistry

, volume 102 , issue 1-2 , pages 55-64

Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity

Mahsa Yazdani ^{1, 2}

Omid Tavakoli ²

Mehdi Khoobi ^{3, 4}

Yi Shuan Wu ⁵

Mohammad Ali Faramarzi ⁶

Elham Gholibegloo ³

Shabnam Farkhondeh ³

Hide authors affiliations Show authors affiliations: 6 affiliations

Mechanical Engineering Department, School of Computing and Engineering, University of Missouri-Kansas City, Kansas City, USA |

School of Chemical Engineering, College of engineering, University of Tehran, Tehran, Iran |

Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran |

⁴

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran |

⁵

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, USA |

⁶

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran |

Publication type: Journal Article

Publication date: 2021-08-25

Springer Nature

Journal of Inclusion Phenomena and Macrocyclic Chemistry

scimago Q3

wos Q3

SJR: 0.364

CiteScore: 3.7

Impact factor: 1.6

ISSN: 13883127, 15731111, 09230750

DOI: 10.1007/s10847-021-01100-7

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General Chemistry

Condensed Matter Physics

Food Science

Abstract

Beta-carotene (BC) is a vitamin A precursor and has potential anticancer benefits, but the delivery of BC is hindered by its low solubility and storage instability. To overcome these challenges, this study investigated the use of fabricated cyclodextrin-based nanosponges (CDNS) using different ratios of two cross-linkers, epiclon (EPI) and hexamethylene diisocyanate (HMDI) to form inclusion complex with BC. The ratios of crosslinkers to βCD for two most optimaly encapsulated CDNSs-BC were determined to be 2:1 for EPI and 4:1 for HMDI with loading efficiency of 61.46% and 59.61%, respectively. The charachterization tests were carefully done for two optimal CDNSs. Encapsulation significantly improved the solubility by ~ 10 folds, 30-day storage stability by 40% compared to BCs. The in vitro release of the two encapsulated products showed no burst release. The MTT assay revealed a variable increase in cytotoxic effect in both normal and cancer cells compared to free BC. Overall, the CDNSs appear to be promising carriers for the delivery of BCs.

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GOST |

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Yazdani M. et al. Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2021. Vol. 102. No. 1-2. pp. 55-64.

GOST all authors (up to 50) Copy

Yazdani M., Tavakoli O., Khoobi M., Wu Y. S., Faramarzi M. A., Gholibegloo E., Farkhondeh S. Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2021. Vol. 102. No. 1-2. pp. 55-64.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1007/s10847-021-01100-7

UR - https://doi.org/10.1007/s10847-021-01100-7

TI - Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity

T2 - Journal of Inclusion Phenomena and Macrocyclic Chemistry

AU - Yazdani, Mahsa

AU - Tavakoli, Omid

AU - Khoobi, Mehdi

AU - Wu, Yi Shuan

AU - Faramarzi, Mohammad Ali

AU - Gholibegloo, Elham

AU - Farkhondeh, Shabnam

PY - 2021

DA - 2021/08/25

PB - Springer Nature

SP - 55-64

IS - 1-2

VL - 102

SN - 1388-3127

SN - 1573-1111

SN - 0923-0750

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Yazdani,

author = {Mahsa Yazdani and Omid Tavakoli and Mehdi Khoobi and Yi Shuan Wu and Mohammad Ali Faramarzi and Elham Gholibegloo and Shabnam Farkhondeh},

title = {Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity},

journal = {Journal of Inclusion Phenomena and Macrocyclic Chemistry},

year = {2021},

volume = {102},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1007/s10847-021-01100-7},

number = {1-2},

pages = {55--64},

doi = {10.1007/s10847-021-01100-7}

}

MLA

Cite this

MLA Copy

Yazdani, Mahsa, et al. “Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity.” Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 102, no. 1-2, Aug. 2021, pp. 55-64. https://doi.org/10.1007/s10847-021-01100-7.

Publisher

Springer Nature

Journal

Journal of Inclusion Phenomena and Macrocyclic Chemistry

scimago Q3

wos Q3

SJR

0.364

CiteScore

3.7

Impact factor

1.6

ISSN

13883127 (Print)

15731111 (Electronic)

09230750 (Print)