Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats
Yuliya V Soldatova
1
,
David A Areshidze
1, 2
,
Alexander V Zhilenkov
1
,
Olga A Kraevaya
1
,
Alexander S. Peregudov
3
,
Daria A Poletaeva
1
,
Irina I Faingold
1
,
Pavel A. Troshin
1
,
Raisa A Kotelnikova
1
Publication type: Journal Article
Publication date: 2021-08-27
scimago Q2
wos Q2
SJR: 0.469
CiteScore: 4.0
Impact factor: 2.6
ISSN: 13880764, 1572896X
General Chemistry
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
General Materials Science
Bioengineering
Modeling and Simulation
Abstract
Water-soluble pentaamino acid fullerene (C60) derivatives (PFD) are promising nanomaterials with a wide range of biomedical applications. The present study has shown that PFD-7 competitively inhibits aldose reductase and sorbitol dehydrogenase, enzymes of the polyol pathway of glucose metabolism, which are known to be associated with diabetic complications. Treatment with PFD-7 was associated with a decrease in blood glucose level and improvement pancreas and liver morphology in rats with type 2 diabetes mellitus (induced by a high fat diet and streptozotocin). The data obtained indicating the ability of pentaamino acid fullerene (C60) derivatives to exhibit a pronounced antidiabetic effect. Thus, PFD-7 may be considered to contribute significantly to treatment of type 2 diabetes mellitus and diabetic complications.
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6
Total citations:
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Citations from 2025:
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(50%)
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Soldatova Y. V. et al. Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats // Journal of Nanoparticle Research. 2021. Vol. 23. No. 9. 202
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Soldatova Y. V., Areshidze D. A., Zhilenkov A. V., Kraevaya O. A., Peregudov A. S., Poletaeva D. A., Faingold I. I., Troshin P. A., Kotelnikova R. A. Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats // Journal of Nanoparticle Research. 2021. Vol. 23. No. 9. 202
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TY - JOUR
DO - 10.1007/s11051-021-05313-2
UR - https://doi.org/10.1007/s11051-021-05313-2
TI - Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats
T2 - Journal of Nanoparticle Research
AU - Soldatova, Yuliya V
AU - Areshidze, David A
AU - Zhilenkov, Alexander V
AU - Kraevaya, Olga A
AU - Peregudov, Alexander S.
AU - Poletaeva, Daria A
AU - Faingold, Irina I
AU - Troshin, Pavel A.
AU - Kotelnikova, Raisa A
PY - 2021
DA - 2021/08/27
PB - Springer Nature
IS - 9
VL - 23
SN - 1388-0764
SN - 1572-896X
ER -
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BibTex (up to 50 authors)
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@article{2021_Soldatova,
author = {Yuliya V Soldatova and David A Areshidze and Alexander V Zhilenkov and Olga A Kraevaya and Alexander S. Peregudov and Daria A Poletaeva and Irina I Faingold and Pavel A. Troshin and Raisa A Kotelnikova},
title = {Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats},
journal = {Journal of Nanoparticle Research},
year = {2021},
volume = {23},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s11051-021-05313-2},
number = {9},
pages = {202},
doi = {10.1007/s11051-021-05313-2}
}
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