A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

Synthesis and transformations of compounds of group IV elements. • Aerobic oxidation; • SiO2-based aerogels; • Catalytic hydrosilylation; • Cross-combination and C-H activation; • HOF, MOF, COF; etc.

Synthesis, study of the structure and properties of super-crosslinked polymer sorbents.

Our group has proposed the concept of reducing addition without an external hydrogen source. In parallel, homogeneous and heterogeneous catalysts are being developed and their activity in carbon-carbon, carbon-nitrogen, carbon-oxygen bond formation reactions is being investigated.

Synthesis of organosilicon compounds of various structures

Novel types of hydrogen bonding involving organometallic compounds and transition metal hydridesIntermolecular interactions and reactivity of main group hydrides including polyhedral boron compounds. Supramolecular design based on macrocyclic pyrazolates of copper(I) or silver(I) and organometallic compoundsMetal-oxo clusters with organoelement and organic ligands.

Various derivatives of sydnonymines are synthesized in Department 109 of the INEOS RAS Laboratory of Fine Organic Synthesis.

The laboratory investigates approaches to the synthesis of mono- and polynuclear pi complexes of d- and f-elements. Special attention is paid to the study of the activity of synthesized metal complex compounds in homogeneous catalysis, as well as the use of products of catalytic reactions in photonics and biochemistry.

The main activities of the Center are related to the analytical applications of modern physico-chemical methods of studying matter (nuclear magnetic resonance spectroscopy, X-ray diffraction, mass spectrometry, optical spectroscopy, microscopy, electrochemistry, etc.) and their use to create materials with specified properties.

Laboratory No.135 is engaged in the synthesis of macrocyclic and acyclic chelators, as well as a comprehensive study of their complexing properties with respect to medical metal cations in order to create diagnostic and therapeutic radiopharmaceuticals based on them. For targeted delivery of the radionuclide complex to the affected area, bifunctional chelating agents and their conjugates with vector molecules such as peptides, antibodies and nanoparticles are being developed. Our research suggests an integrated approach to solving the task, starting from the design of the structure of chelators, the development of methods for their synthesis and ending with a complete analysis of their complexing characteristics. To do this, we use methods of HPLC, mass spectrometry, NMR spectroscopy, X-ray diffraction analysis, quantum chemical calculations, potentiometric and spectrophotometric titration, as well as radionuclide labeling and stability analyses in vitro and in vivo. In the course of our research, we identify the advantages and disadvantages of new ligands and identify patterns that affect their ability to bind a particular metal cation. The results obtained make it possible to expand the range of possible new radiopharmaceuticals for the diagnosis and treatment of oncological diseases, which is currently extremely relevant.

Synthesis and study of the reactivity of polyhedral boranes, carboranes and metallacarboranes. Development of new boron-containing materials and medicals.