Springer Nature
Neuroscience and Behavioral Physiology
,  volume 42 ,  issue 6 ,  pages 582-587

Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo

Publication type: Journal Article
Publication date: 2012-07-01
Springer Nature
scimago Q4
SJR: 0.183
CiteScore: 0.7
Impact factor: —
ISSN: 00970549, 1573899X
General Neuroscience
Abstract
The effects of intracerebral intraventricular administration of the nonselective cannabinoid CB1 receptor WIN 55.212-2 (1 μM, 2 μl) on seizure activity were studied in conscious guinea pigs. Changes in local field potential and convulsive discharges evoked by electrical stimulation of the perforant path were recorded simultaneously in the hippocampus, entorhinal cortex, medial septal area, and amygdala after prior administration of WIN 55.212-2 or the organic solvent DMSO. In 80% of tests, WIN 55.212-2 was found to block the development of seizure activity. Repeated injections of agonist for 30 days increased the amplitude of local field potentials and the power of the theta rhythm in all structures recorded. Administration of kainic acid provoked status epilepticus in control animals, while status epilepticus did not arise in guinea pigs given daily agonist injections for 25–30 days. The possible mechanisms of the protective effects of WIN 55.212-2 are discussed.
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Shubina L. V., Kichigina V. F. Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo // Neuroscience and Behavioral Physiology. 2012. Vol. 42. No. 6. pp. 582-587.
GOST all authors (up to 50) Copy
Shubina L. V., Kichigina V. F. Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo // Neuroscience and Behavioral Physiology. 2012. Vol. 42. No. 6. pp. 582-587.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11055-012-9604-0
UR - https://doi.org/10.1007/s11055-012-9604-0
TI - Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo
T2 - Neuroscience and Behavioral Physiology
AU - Shubina, L. V.
AU - Kichigina, V F
PY - 2012
DA - 2012/07/01
PB - Springer Nature
SP - 582-587
IS - 6
VL - 42
SN - 0097-0549
SN - 1573-899X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2012_Shubina,
author = {L. V. Shubina and V F Kichigina},
title = {Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo},
journal = {Neuroscience and Behavioral Physiology},
year = {2012},
volume = {42},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007/s11055-012-9604-0},
number = {6},
pages = {582--587},
doi = {10.1007/s11055-012-9604-0}
}
MLA
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MLA Copy
Shubina, L. V., et al. “Protective effects of the CB1 receptor agonist WIN 55.212-2 during development of seizure activity in the brain in models of temporal epilepsy in vivo.” Neuroscience and Behavioral Physiology, vol. 42, no. 6, Jul. 2012, pp. 582-587. https://doi.org/10.1007/s11055-012-9604-0.