Neuroscience and Behavioral Physiology, volume 51, issue 7, pages 893-914
Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends?
Publication type: Journal Article
Publication date: 2021-09-01
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 00970549, 1573899X
General Neuroscience
Abstract
Cannabinoids are natural compounds found in the hemp (Cannabis sativa). Scientific interest in cannabinoids arose after the discovery of the major psychoactive component in hemp, Δ9-tetrahydrocannabinol. Subsequent studies detected receptors in the brain subject to the actions of this compound, along with ligands for these receptors, i.e., endogenous cannabinoids (EC), which make up, along with the enzymes synthesizing, transporting, and degrading them, the endocannabinoid system (ECS). Interest in EC has consistently increased in recent years, especially after their important role in cognitive functions was discovered. They are regulators of synaptic transmission in the brain, mediate numerous forms of plasticity, and control neuron energy metabolism. EC exert influences using a series of mechanisms and interactions with neuromediators, neurotrophic factors, and neuropeptides. The main functions of EC in the brain are retrograde synaptic signaling and neuromodulation, which maintain cellular homeostasis. Information on the influences of cannabinoid drugs on cognitive functions is very contradictory. The cause of this may be that there are still inadequate strictly scientific data from clinical and sociological studies, while in animal experiments different authors use different methods and approaches for actions on the ECS. Thus, effects can differ depending on the substances used, their doses, and routes of administration, and the tasks and experimental conditions selected for testing. There is an extensive literature on the protective effect of ECS activation in neurodegenerative diseases in humans and models of cognitive deficit in animals. This review addresses data providing evidence of the influences of cannabinoid drugs and activation of the EC system on cognitive functions in the normal brain and in neurodegenerative diseases, Alzheimer’s disease, and temporal epilepsy. The possible causes of contradictions in existing data are also discussed.
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Advances in Experimental Medicine and Biology
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Advances in Experimental Medicine and Biology
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Springer Nature
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Springer Nature
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Kitchigina V. F. Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends? // Neuroscience and Behavioral Physiology. 2021. Vol. 51. No. 7. pp. 893-914.
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Kitchigina V. F. Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends? // Neuroscience and Behavioral Physiology. 2021. Vol. 51. No. 7. pp. 893-914.
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TY - JOUR
DO - 10.1007/s11055-021-01148-5
UR - https://doi.org/10.1007%2Fs11055-021-01148-5
TI - Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends?
T2 - Neuroscience and Behavioral Physiology
AU - Kitchigina, V. F.
PY - 2021
DA - 2021/09/01 00:00:00
PB - Springer Nature
SP - 893-914
IS - 7
VL - 51
SN - 0097-0549
SN - 1573-899X
ER -
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@article{2021_Kitchigina
author = {V. F. Kitchigina},
title = {Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends?},
journal = {Neuroscience and Behavioral Physiology},
year = {2021},
volume = {51},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007%2Fs11055-021-01148-5},
number = {7},
pages = {893--914},
doi = {10.1007/s11055-021-01148-5}
}
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Kitchigina, V. F.. “Cannabinoids, the Endocannabinoid System, and Cognitive Functions: Enemies or Friends?.” Neuroscience and Behavioral Physiology, vol. 51, no. 7, Sep. 2021, pp. 893-914. https://doi.org/10.1007%2Fs11055-021-01148-5.
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