Pharmaceutical Chemistry Journal, том 54, издание 1, номера страниц: 49-56

Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

Sapel’nikov M. D. 1
, 
Nikol’skaya E. D. 2
, 
Morozova N. B. 3
, 
Plotnikova E. A. 3
, 
Pankratov A. A. 3
, 
Efremenko A. V. 4, 5
, 
Panov A. V. 1, 6
, 
Grin M. A. 1
, 
Yakubovskaya R. I. 3
1
 
2
 
All-Russia Scientific Center for Molecular Diagnostics and Therapy (ASCMDT), Moscow, Russia
3
 
P. A. Herzen Moscow Oncology Research Institute, Branch of National Medical Research Center for Radiology, Ministry of Health of the RF, Moscow, Russia
4
 
5
 
6
 
Institute of Pharmaceutical Technologies, Moscow, Russia
Тип документа: Journal Article
Дата публикации: 2020-04
Издатель: Springer Nature
Название журнала: Pharmaceutical Chemistry Journal
Квартиль по SCImago: Q4
Квартиль по Web of Science: Q4
Импакт-фактор 2021: 1.06
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
The production technology for nanoparticles based on a copolymer of lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) and intended for photodynamic therapy of malignant neoplasms of various etiology is optimized. An approach to reducing the average diameter of the resulting nanoparticles is proposed. The obtained DPBPI-PLGA nanoparticles had average diameter 142.3 ± 2.7 nm; ξ-potential 17.1 ± 3.42 mV; polydispersity index 0.095; and total DPBPI content in DPBPI-PLGA particles 17.4 mg/g. DPBPI-PLGA nanoparticles were produced for biological tests. The intracellular distribution of DPBPI in DPBPI-PLGA nanoparticles was studied in in vitro experiments on A549 cells. DPBPI accumulation kinetics in and elimination kinetics from the cells were also studied. DPBPI-PLGA showed high photoinduced cytotoxicity in in vitro experiments. DPBPI-PLGA nanoparticles exhibited antitumor activity in in vivo experiments in an S37 murine soft tissue sarcoma model.
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1. Sapel’nikov M.D. и др. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Т. 54. № 1. С. 49–56.
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TY - JOUR

DO - 10.1007/s11094-020-02154-6

UR - http://dx.doi.org/10.1007/s11094-020-02154-6

TI - Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

T2 - Pharmaceutical Chemistry Journal

AU - Sapel’nikov, M. D.

AU - Nikol’skaya, E. D.

AU - Morozova, N. B.

AU - Plotnikova, E. A.

AU - Pankratov, A. A.

AU - Efremenko, A. V.

AU - Panov, A. V.

AU - Grin, M. A.

AU - Yakubovskaya, R. I.

PY - 2020

DA - 2020/04

PB - Springer Science and Business Media LLC

SP - 49-56

IS - 1

VL - 54

SN - 0091-150X

SN - 1573-9031

ER -

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@article{Sapel_nikov_2020,

doi = {10.1007/s11094-020-02154-6},

url = {https://doi.org/10.1007%2Fs11094-020-02154-6},

year = 2020,

month = {apr},

publisher = {Springer Science and Business Media {LLC}},

volume = {54},

number = {1},

pages = {49--56},

author = {M. D. Sapel'nikov and E. D. Nikol'skaya and N. B. Morozova and E. A. Plotnikova and A. A. Pankratov and A. V. Efremenko and A. V. Panov and M. A. Grin and R. I. Yakubovskaya},

title = {Physicochemical and Biological Properties of a Nanostructured {IR}-Photosensitizer Based on Dipropoxybacteriopurpurinimide},

journal = {Pharmaceutical Chemistry Journal}

}

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Sapel’nikov, M. D. et al. “Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide.” Pharmaceutical Chemistry Journal 54.1 (2020): 49–56. Crossref. Web.