Pharmaceutical Chemistry Journal

, volume 54 , issue 1 , pages 49-56

Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

M D Sapelnikov ¹

E D Nikolskaya ²

N. B. Morozova ³

E A Plotnikova ³

A. A. Pankratov ³

A V Efremenko ^{4, 5}

A. V. Panov ^{1, 6}

M A Grin ¹

R. I. Yakubovskaya ³

Hide authors affiliations Show authors affiliations: 6 affiliations

MIREA – Russian Technological University, 86 Prosp. Vernadskogo, Moscow, Russia |

All-Russia Scientific Center for Molecular Diagnostics and Therapy (ASCMDT), Moscow, Russia |

P. A. Herzen Moscow Oncology Research Institute, Branch of National Medical Research Center for Radiology, Ministry of Health of the RF, Moscow, Russia |

⁴

M. M. Shemyakin – Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia |

⁵

Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia |

⁶

Institute of Pharmaceutical Technologies, Moscow, Russia |

Publication type: Journal Article

Publication date: 2020-04-25

Springer Nature

Pharmaceutical Chemistry Journal

scimago Q4

wos Q4

SJR: 0.219

CiteScore: 1.4

Impact factor: 1.0

ISSN: 0091150X, 15739031

DOI: 10.1007/s11094-020-02154-6

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Drug Discovery

Pharmacology

Abstract

The production technology for nanoparticles based on a copolymer of lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) and intended for photodynamic therapy of malignant neoplasms of various etiology is optimized. An approach to reducing the average diameter of the resulting nanoparticles is proposed. The obtained DPBPI-PLGA nanoparticles had average diameter 142.3 ± 2.7 nm; ξ-potential 17.1 ± 3.42 mV; polydispersity index 0.095; and total DPBPI content in DPBPI-PLGA particles 17.4 mg/g. DPBPI-PLGA nanoparticles were produced for biological tests. The intracellular distribution of DPBPI in DPBPI-PLGA nanoparticles was studied in in vitro experiments on A549 cells. DPBPI accumulation kinetics in and elimination kinetics from the cells were also studied. DPBPI-PLGA showed high photoinduced cytotoxicity in in vitro experiments. DPBPI-PLGA nanoparticles exhibited antitumor activity in in vivo experiments in an S37 murine soft tissue sarcoma model.

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Sapelnikov M. D. et al. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.

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Sapelnikov M. D., Nikolskaya E. D., Morozova N. B., Plotnikova E. A., Pankratov A. A., Efremenko A. V., Panov A. V., Grin M. A., Yakubovskaya R. I. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s11094-020-02154-6

UR - https://doi.org/10.1007/s11094-020-02154-6

TI - Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

T2 - Pharmaceutical Chemistry Journal

AU - Sapelnikov, M D

AU - Nikolskaya, E D

AU - Morozova, N. B.

AU - Plotnikova, E A

AU - Pankratov, A. A.

AU - Efremenko, A V

AU - Panov, A. V.

AU - Grin, M A

AU - Yakubovskaya, R. I.

PY - 2020

DA - 2020/04/25

PB - Springer Nature

SP - 49-56

IS - 1

VL - 54

SN - 0091-150X

SN - 1573-9031

ER -

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BibTex (up to 50 authors) Copy

@article{2020_Sapelnikov,

author = {M D Sapelnikov and E D Nikolskaya and N. B. Morozova and E A Plotnikova and A. A. Pankratov and A V Efremenko and A. V. Panov and M A Grin and R. I. Yakubovskaya},

title = {Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide},

journal = {Pharmaceutical Chemistry Journal},

year = {2020},

volume = {54},

publisher = {Springer Nature},

month = {apr},

url = {https://doi.org/10.1007/s11094-020-02154-6},

number = {1},

pages = {49--56},

doi = {10.1007/s11094-020-02154-6}

}

MLA

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Sapelnikov, M. D., et al. “Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide.” Pharmaceutical Chemistry Journal, vol. 54, no. 1, Apr. 2020, pp. 49-56. https://doi.org/10.1007/s11094-020-02154-6.