Pharmaceutical Chemistry Journal, volume 54, issue 1, pages 49-56
Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide
Sapelnikov M D
1
,
Nikolskaya E D
2
,
Morozova N. B.
3
,
Plotnikova E A
3
,
Pankratov A. A.
3
,
Efremenko A V
4, 5
,
Panov A. V.
1, 6
,
Grin M A
1
,
Yakubovskaya R. I.
3
2
All-Russia Scientific Center for Molecular Diagnostics and Therapy (ASCMDT), Moscow, Russia
|
6
Institute of Pharmaceutical Technologies, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2020-04-25
Journal:
Pharmaceutical Chemistry Journal
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 0.9
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
The production technology for nanoparticles based on a copolymer of lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) and intended for photodynamic therapy of malignant neoplasms of various etiology is optimized. An approach to reducing the average diameter of the resulting nanoparticles is proposed. The obtained DPBPI-PLGA nanoparticles had average diameter 142.3 ± 2.7 nm; ξ-potential 17.1 ± 3.42 mV; polydispersity index 0.095; and total DPBPI content in DPBPI-PLGA particles 17.4 mg/g. DPBPI-PLGA nanoparticles were produced for biological tests. The intracellular distribution of DPBPI in DPBPI-PLGA nanoparticles was studied in in vitro experiments on A549 cells. DPBPI accumulation kinetics in and elimination kinetics from the cells were also studied. DPBPI-PLGA showed high photoinduced cytotoxicity in in vitro experiments. DPBPI-PLGA nanoparticles exhibited antitumor activity in in vivo experiments in an S37 murine soft tissue sarcoma model.
Citations by journals
1
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Photodiagnosis and Photodynamic Therapy
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Photodiagnosis and Photodynamic Therapy
1 publication, 100%
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1
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Citations by publishers
1
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|
Elsevier
|
Elsevier
1 publication, 100%
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1
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- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sapelnikov M. D. et al. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.
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Sapelnikov M. D., Nikolskaya E. D., Morozova N. B., Plotnikova E. A., Pankratov A. A., Efremenko A. V., Panov A. V., Grin M. A., Yakubovskaya R. I. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.
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TY - JOUR
DO - 10.1007/s11094-020-02154-6
UR - https://doi.org/10.1007%2Fs11094-020-02154-6
TI - Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide
T2 - Pharmaceutical Chemistry Journal
AU - Sapelnikov, M D
AU - Nikolskaya, E D
AU - Morozova, N. B.
AU - Plotnikova, E A
AU - Panov, A. V.
AU - Pankratov, A. A.
AU - Grin, M A
AU - Yakubovskaya, R. I.
AU - Efremenko, A V
PY - 2020
DA - 2020/04/25 00:00:00
PB - Springer Nature
SP - 49-56
IS - 1
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2020_Sapelnikov
author = {M D Sapelnikov and E D Nikolskaya and N. B. Morozova and E A Plotnikova and A. V. Panov and A. A. Pankratov and M A Grin and R. I. Yakubovskaya and A V Efremenko},
title = {Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide},
journal = {Pharmaceutical Chemistry Journal},
year = {2020},
volume = {54},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs11094-020-02154-6},
number = {1},
pages = {49--56},
doi = {10.1007/s11094-020-02154-6}
}
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Sapelnikov, M. D., et al. “Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide.” Pharmaceutical Chemistry Journal, vol. 54, no. 1, Apr. 2020, pp. 49-56. https://doi.org/10.1007%2Fs11094-020-02154-6.
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