Pharmaceutical Chemistry Journal, volume 54, issue 1, pages 49-56

Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

Sapelnikov M D 1
Morozova N. B. 3
Plotnikova E A 3
Pankratov A. A. 3
Efremenko A V 4, 5
Panov A. V. 1, 6
Grin M A 1
Yakubovskaya R. I. 3
Publication typeJournal Article
Publication date2020-04-25
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor0.9
ISSN0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
The production technology for nanoparticles based on a copolymer of lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) and intended for photodynamic therapy of malignant neoplasms of various etiology is optimized. An approach to reducing the average diameter of the resulting nanoparticles is proposed. The obtained DPBPI-PLGA nanoparticles had average diameter 142.3 ± 2.7 nm; ξ-potential 17.1 ± 3.42 mV; polydispersity index 0.095; and total DPBPI content in DPBPI-PLGA particles 17.4 mg/g. DPBPI-PLGA nanoparticles were produced for biological tests. The intracellular distribution of DPBPI in DPBPI-PLGA nanoparticles was studied in in vitro experiments on A549 cells. DPBPI accumulation kinetics in and elimination kinetics from the cells were also studied. DPBPI-PLGA showed high photoinduced cytotoxicity in in vitro experiments. DPBPI-PLGA nanoparticles exhibited antitumor activity in in vivo experiments in an S37 murine soft tissue sarcoma model.

Citations by journals

1
Photodiagnosis and Photodynamic Therapy
Photodiagnosis and Photodynamic Therapy, 1, 100%
Photodiagnosis and Photodynamic Therapy
1 publication, 100%
1

Citations by publishers

1
Elsevier
Elsevier, 1, 100%
Elsevier
1 publication, 100%
1
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Sapelnikov M. D. et al. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.
GOST all authors (up to 50) Copy
Sapelnikov M. D., Nikolskaya E. D., Morozova N. B., Plotnikova E. A., Pankratov A. A., Efremenko A. V., Panov A. V., Grin M. A., Yakubovskaya R. I. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 1. pp. 49-56.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s11094-020-02154-6
UR - https://doi.org/10.1007%2Fs11094-020-02154-6
TI - Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide
T2 - Pharmaceutical Chemistry Journal
AU - Sapelnikov, M D
AU - Nikolskaya, E D
AU - Morozova, N. B.
AU - Plotnikova, E A
AU - Panov, A. V.
AU - Pankratov, A. A.
AU - Grin, M A
AU - Yakubovskaya, R. I.
AU - Efremenko, A V
PY - 2020
DA - 2020/04/25 00:00:00
PB - Springer Nature
SP - 49-56
IS - 1
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Sapelnikov
author = {M D Sapelnikov and E D Nikolskaya and N. B. Morozova and E A Plotnikova and A. V. Panov and A. A. Pankratov and M A Grin and R. I. Yakubovskaya and A V Efremenko},
title = {Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide},
journal = {Pharmaceutical Chemistry Journal},
year = {2020},
volume = {54},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs11094-020-02154-6},
number = {1},
pages = {49--56},
doi = {10.1007/s11094-020-02154-6}
}
MLA
Cite this
MLA Copy
Sapelnikov, M. D., et al. “Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide.” Pharmaceutical Chemistry Journal, vol. 54, no. 1, Apr. 2020, pp. 49-56. https://doi.org/10.1007%2Fs11094-020-02154-6.
Found error?