Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

Sapel’nikov M.D., Nikol’skaya E.D., Morozova N.B., Plotnikova E.A., Pankratov A.A., Efremenko A.V., Panov A.V., Grin M.A., Yakubovskaya R.I.
Тип документаJournal Article
Дата публикации2020-04-25
Название журналаPharmaceutical Chemistry Journal
ИздательSpringer Nature
Квартиль по SCImagoQ4
Квартиль по Web of ScienceQ4
Импакт-фактор 20211.06
ISSN0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
The production technology for nanoparticles based on a copolymer of lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) and intended for photodynamic therapy of malignant neoplasms of various etiology is optimized. An approach to reducing the average diameter of the resulting nanoparticles is proposed. The obtained DPBPI-PLGA nanoparticles had average diameter 142.3 ± 2.7 nm; ξ-potential 17.1 ± 3.42 mV; polydispersity index 0.095; and total DPBPI content in DPBPI-PLGA particles 17.4 mg/g. DPBPI-PLGA nanoparticles were produced for biological tests. The intracellular distribution of DPBPI in DPBPI-PLGA nanoparticles was studied in in vitro experiments on A549 cells. DPBPI accumulation kinetics in and elimination kinetics from the cells were also studied. DPBPI-PLGA showed high photoinduced cytotoxicity in in vitro experiments. DPBPI-PLGA nanoparticles exhibited antitumor activity in in vivo experiments in an S37 murine soft tissue sarcoma model.
Пристатейные ссылки: 11
Цитируется в публикациях: 1
Synthesis and properties of Cu- and Pd-complexes of cyclen conjugates with pheophorbide and bacteriopheophorbide
Smirnov A.S., Grin M.A., Mironov A.F.
Fine Chemical Technologies 2020 цитирований: 5
Development of the technology for obtaining PLGA and dipropoxybateriopurpurinimide-based nanoparticles. Evaluation of physicochemical and biological properties of the obtained delivery system
Sapelnikov M.D., Nikolskaya E.D., Morozova N.B., Plotnikova E.A., Efremenko A.V., Panov A.V., Grin M.A., Yakubovskaya R.I.
Q3 Biomedical Photonics 2019 цитирований: 1
Open Access
Open access
Effects of Size and Surface Charge of Polymeric Nanoparticles on in Vitro and in Vivo Applications
Sadat S.M., Jahan S.T., Haddadi A.
Journal of Biomaterials and Nanobiotechnology 2016 цитирований: 75
Pathways of clathrin-independent endocytosis
Mayor S., Pagano R.E.
Q1 Nature Reviews Molecular Cell Biology 2007 цитирований: 1027
Метрики
Поделиться
Цитировать
ГОСТ |
Цитировать
1. Sapel’nikov M.D. и др. Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide // Pharmaceutical Chemistry Journal. 2020. Т. 54. № 1. С. 49–56.
RIS |
Цитировать

TY - JOUR

DO - 10.1007/s11094-020-02154-6

UR - http://dx.doi.org/10.1007/s11094-020-02154-6

TI - Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide

T2 - Pharmaceutical Chemistry Journal

AU - Sapel’nikov, M. D.

AU - Nikol’skaya, E. D.

AU - Morozova, N. B.

AU - Plotnikova, E. A.

AU - Pankratov, A. A.

AU - Efremenko, A. V.

AU - Panov, A. V.

AU - Grin, M. A.

AU - Yakubovskaya, R. I.

PY - 2020

DA - 2020/04

PB - Springer Science and Business Media LLC

SP - 49-56

IS - 1

VL - 54

SN - 0091-150X

SN - 1573-9031

ER -

BibTex |
Цитировать

@article{Sapel_nikov_2020,

doi = {10.1007/s11094-020-02154-6},

url = {https://doi.org/10.1007%2Fs11094-020-02154-6},

year = 2020,

month = {apr},

publisher = {Springer Science and Business Media {LLC}},

volume = {54},

number = {1},

pages = {49--56},

author = {M. D. Sapel'nikov and E. D. Nikol'skaya and N. B. Morozova and E. A. Plotnikova and A. A. Pankratov and A. V. Efremenko and A. V. Panov and M. A. Grin and R. I. Yakubovskaya},

title = {Physicochemical and Biological Properties of a Nanostructured {IR}-Photosensitizer Based on Dipropoxybacteriopurpurinimide},

journal = {Pharmaceutical Chemistry Journal}

}

MLA
Цитировать
Sapel’nikov, M. D. et al. “Physicochemical and Biological Properties of a Nanostructured IR-Photosensitizer Based on Dipropoxybacteriopurpurinimide.” Pharmaceutical Chemistry Journal 54.1 (2020): 49–56. Crossref. Web.