Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Laboratory of Biotechnologies and Nanostructures for targeted drug delivery

Nanotechnology Oncology Cell Biology
Head of Laboratory

Nikolskaya, Elena D

PhD in Chemistry
CoLab Scopus
Publications
56
Citations
225
h-index
7
Publications
57
Citations
250
h-index
8
Authorization required.
Lab website
Lab team

Development of nanoscale targeted drug delivery systems.

As delivery systems, we develop, optimize and scale the technology for producing polymer particles.

We carry out a full range of preclinical tests in vitro and in vivo.

We analyze drugs using various physico-chemical and biological methods, develop and optimize analytical techniques, and perform validation. Analysis using HPLC.

Production of recombinant proteins and peptides.

Writing and execution of various accounting and regulatory documents.

  1. High-efficiency liquid chromatography (HPLC)
  2. Spectrophotometry
  3. Enzyme-linked immunosorbent assay (ELISA)
  4. Western blot
  5. Flow cytometry
  6. Cell and tissue culture
  7. Working with laboratory animals
  8. Various methods for the production of biomaterials/biocomposites, supramolecular complexes and sols of nanoparticles.
  9. Affinity chromatography
  10. Subtle organic synthesis
  11. Thin-layer chromatography
  12. UV spectroscopy
  13. Extraction
  14. Solid-phase extraction
  15. Column chromatography
  16. Working with bacterial strains
  17. Isolation and purification of target proteins
  18. Ultracentrifugation
  19. Recombinant protein expression
  20. PCR
  21. Gel electrophoresis
Elena Nikolskaya 🤝
Head of Laboratory
Yabbarov, Nikita G
Nikita Yabbarov
Senior Researcher
Sokol, Maria B
Maria Sokol
Junior researcher
Mollaeva, Mariia R
Mariia Mollaeva
Junior researcher
Chirkina, Margarita V
Margarita Chirkina
Junior researcher

Research directions

Obtaining nanoscale targeted delivery systems

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Publications and patents

By date By citations
Елена Дмитриевна Никольская, Никита Григорьевич Яббаров, Мария Борисовна Сокол, Ольга Александровна Жунина, Мария Романовна Фаустова, Артур Игоревич Заболотский, Маргарита Викторовна Фомичева, Мурад Давлетович Моллаев, Татьяна Анатольевна Помазкова, Михаил Александрович Сапелкин
RU2727924C1, 2020
Елена Дмитриевна Никольская, Никита Григорьевич Яббаров, Ольга Александровна Жунина, Евгений Сергеевич Северин
RU2630974C1, 2017
Надежда Вадимовна Гукасова, Ольга Александровна Жунина, Елена Дмитриевна Никольская, Александр Васильевич Помазков, Михаил Александрович Сапелкин, Евгений Сергеевич Северин, Оксана Геннадьевна Терещенко, Никита Григорьевич Яббаров
RU2617511C1, 2017
Elena Nikolskaya, Evgeny VORONTSOV, Evgenij SEVERIN, Victor GULENKO, Maxim Mitrokhin, Maksim IURCHENKO, Nikita PANKOV
WO2015071543, 2015

Partners

Lomonosov Moscow State University
Mendeleev University of Chemical Technology of Russia
MIREA - Russian Technological University (RTU MIREA)
N.N. Semenov Federal Research Center for Chemical Physics RAS
Moscow Institute of Physics and Technology
National Research Centre "Kurchatov Institute"
Bach Institute of Biochemistry
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Lab address

ул. Косыгина, 4, Москва, 119334
Authorization required.