Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Laboratory of Biotechnologies and Nanostructures for targeted drug delivery

Nanotechnology Oncology Cell Biology

Head of Laboratory

Nikolskaya, Elena D

PhD in Chemistry

Publications

Citations

277

h-index

Authorization required.

Lab website

Development of nanoscale targeted drug delivery systems.

As delivery systems, we develop, optimize and scale the technology for producing polymer particles.

We carry out a full range of preclinical tests in vitro and in vivo.

We analyze drugs using various physico-chemical and biological methods, develop and optimize analytical techniques, and perform validation. Analysis using HPLC.

Production of recombinant proteins and peptides.

Writing and execution of various accounting and regulatory documents.

High-efficiency liquid chromatography (HPLC)
Spectrophotometry
Enzyme-linked immunosorbent assay (ELISA)
Western blot
Flow cytometry
Cell and tissue culture
Working with laboratory animals
Various methods for the production of biomaterials/biocomposites, supramolecular complexes and sols of nanoparticles.
Affinity chromatography
Subtle organic synthesis
Thin-layer chromatography
UV spectroscopy
Extraction
Solid-phase extraction
Column chromatography
Working with bacterial strains
Isolation and purification of target proteins
Ultracentrifugation
Recombinant protein expression
PCR
Gel electrophoresis

Elena Nikolskaya 🤝

Head of Laboratory

Nikita Yabbarov

Senior Researcher

Maria Sokol

Junior researcher

Mariia Mollaeva

Junior researcher

Margarita Chirkina

Junior researcher

Research directions

Obtaining nanoscale targeted delivery systems

Publications and patents

Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells

Journal of Biomedical Materials Research - Part B Applied Biomaterials (Q2), 2018, Citations: 35

Metalloporphyrins in Medicine: From History to Recent Trends.

ACS Applied Bio Materials (Q1), 2020, Citations: 26

Type of pH sensitive linker reveals different time-dependent intracellular localization, in vitro and in vivo efficiency in alpha-fetoprotein receptor targeted doxorubicin conjugate

International Journal of Pharmaceutics (Q1), 2019, Citations: 17

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

International Journal of Molecular Sciences (Q1), 2021, Citations: 17

High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy

Free Radical Biology and Medicine (Q1), 2019, Citations: 15

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Antioxidants (Q1), 2021, Citations: 13

By date By citations

Высокоэффективный способ получения лекарственной формы адресного действия для терапии злокачественных новообразований

Елена Дмитриевна Никольская, Никита Григорьевич Яббаров, Мария Борисовна Сокол, Ольга Александровна Жунина, Мария Романовна Фаустова, Артур Игоревич Заболотский, Маргарита Викторовна Фомичева, Мурад Давлетович Моллаев, Татьяна Анатольевна Помазкова, Михаил Александрович Сапелкин

RU2727924C1, 2020

Конъюгат противоопухолевых препаратов с рекомбинантным альфа-фетопротеином и его функциональными фрагментами и способ их получения

Елена Дмитриевна Никольская, Никита Григорьевич Яббаров, Ольга Александровна Жунина, Евгений Сергеевич Северин

RU2630974C1, 2017

Фармацевтическая композиция для химиотерапии онкологических заболеваний и способ ее получения

Надежда Вадимовна Гукасова, Ольга Александровна Жунина, Елена Дмитриевна Никольская, Александр Васильевич Помазков, Михаил Александрович Сапелкин, Евгений Сергеевич Северин, Оксана Геннадьевна Терещенко, Никита Григорьевич Яббаров

RU2617511C1, 2017

Josamycin-based pharmaceutical composition and a process for preparing the same

Elena Nikolskaya, Evgeny VORONTSOV, Evgenij SEVERIN, Victor GULENKO, Maxim Mitrokhin, Maksim IURCHENKO, Nikita PANKOV

WO2015071543, 2015

Совместное инкапсулирование препаратов в наночастицы как новая стратегия комбинированной терапии злокачественных новообразований молочной железы

2022 — 2023

| Никольская Елена Дмитриевна