Pharmaceutical Chemistry Journal, том 54, издание 8, номера страниц: 846-850

Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles

Sokol M. B. 1, 2
, 
Sycheva Yu. V. 1
, 
Yabbarov N. G. 1, 2
, 
Zabolotskii A. I. 1, 3
, 
Mollaev M. D. 1, 4
, 
Faustova M. R. 1, 2, 4
, 
Tereshchenko O. G. 1
, 
Fomicheva M. V. 1, 2
, 
Nikol’skaya E. D. 1, 2
1
 
Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia
2
 
3
 
4
 
Тип документа: Journal Article
Дата публикации: 2020-11-19
Издатель: Springer Nature
Название журнала: Pharmaceutical Chemistry Journal
Квартиль по SCImago: Q4
Квартиль по Web of Science: Q4
Импакт-фактор 2021: 1.06
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer nanoparticles and a protein vector (recombinant third domain of alpha-fetoprotein) was developed. Paclitaxel was determined at wavelength 260 ± 2 nm. The proposed method showed specificity, linearity (R2 = 0.9948) in the range 80 – 120% of paclitaxel nominal load in the polymer matrix (0.18 mg/mL), accuracy, and precision. The developed method could be recommended for inclusion in regulatory documentation for quality control of paclitaxel nanoparticles conjugated with a protein vector.
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1. Sokol M.B. и др. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Т. 54. № 8. С. 846–850.
RIS |
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TY - JOUR

DO - 10.1007/s11094-020-02285-w

UR - http://dx.doi.org/10.1007/s11094-020-02285-w

TI - Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles

T2 - Pharmaceutical Chemistry Journal

AU - Sokol, M. B.

AU - Sycheva, Yu. V.

AU - Yabbarov, N. G.

AU - Zabolotskii, A. I.

AU - Mollaev, M. D.

AU - Faustova, M. R.

AU - Tereshchenko, O. G.

AU - Fomicheva, M. V.

AU - Nikol’skaya, E. D.

PY - 2020

DA - 2020/11

PB - Springer Science and Business Media LLC

SP - 846-850

IS - 8

VL - 54

SN - 0091-150X

SN - 1573-9031

ER -

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@article{Sokol_2020,

doi = {10.1007/s11094-020-02285-w},

url = {https://doi.org/10.1007%2Fs11094-020-02285-w},

year = 2020,

month = {nov},

publisher = {Springer Science and Business Media {LLC}},

volume = {54},

number = {8},

pages = {846--850},

author = {M. B. Sokol and Yu. V. Sycheva and N. G. Yabbarov and A. I. Zabolotskii and M. D. Mollaev and M. R. Faustova and O. G. Tereshchenko and M. V. Fomicheva and E. D. Nikol'skaya},

title = {Validation of a {UV}-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic{\textendash}Glycolic Acid) Copolymer Nanoparticles},

journal = {Pharmaceutical Chemistry Journal}

}

MLA
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Sokol, M. B. et al. “Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles.” Pharmaceutical Chemistry Journal 54.8 (2020): 846–850. Crossref. Web.