Pharmaceutical Chemistry Journal

, том 54 , издание 8 , страницы 846-850

Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles

Тип публикации: Journal Article

Дата публикации: 2020-11-19

Springer Nature

Pharmaceutical Chemistry Journal

scimago Q4

wos Q4

БС3

SJR: 0.219

CiteScore: 1.4

Impact factor: 1.0

ISSN: 0091150X, 15739031

DOI: 10.1007/s11094-020-02285-w

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Drug Discovery

Pharmacology

Краткое описание

A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer nanoparticles and a protein vector (recombinant third domain of alpha-fetoprotein) was developed. Paclitaxel was determined at wavelength 260 ± 2 nm. The proposed method showed specificity, linearity (R2 = 0.9948) in the range 80 – 120% of paclitaxel nominal load in the polymer matrix (0.18 mg/mL), accuracy, and precision. The developed method could be recommended for inclusion in regulatory documentation for quality control of paclitaxel nanoparticles conjugated with a protein vector.

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Emergent Materials	Emergent Materials, 1, 50% Emergent Materials 1 публикация, 50%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 50% International Journal of Biological Macromolecules 1 публикация, 50%
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Sokol M. B. et al. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.

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Sokol M. B., Sycheva Yu. V., Yabbarov N. G., Zabolotskii A. I., Mollaev M. D., Faustova M. R., Tereshchenko O. G., Fomicheva M. V., Nikolskaya E. D. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.

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TY - JOUR

DO - 10.1007/s11094-020-02285-w

UR - https://doi.org/10.1007/s11094-020-02285-w

TI - Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles

T2 - Pharmaceutical Chemistry Journal

AU - Sokol, M B

AU - Sycheva, Yu V

AU - Yabbarov, N G

AU - Zabolotskii, A I

AU - Mollaev, M D

AU - Faustova, M R

AU - Tereshchenko, O G

AU - Fomicheva, M V

AU - Nikolskaya, E D

PY - 2020

DA - 2020/11/19

PB - Springer Nature

SP - 846-850

IS - 8

VL - 54

SN - 0091-150X

SN - 1573-9031

ER -

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@article{2020_Sokol,

author = {M B Sokol and Yu V Sycheva and N G Yabbarov and A I Zabolotskii and M D Mollaev and M R Faustova and O G Tereshchenko and M V Fomicheva and E D Nikolskaya},

title = {Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles},

journal = {Pharmaceutical Chemistry Journal},

year = {2020},

volume = {54},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1007/s11094-020-02285-w},

number = {8},

pages = {846--850},

doi = {10.1007/s11094-020-02285-w}

}

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Sokol, M. B., et al. “Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles.” Pharmaceutical Chemistry Journal, vol. 54, no. 8, Nov. 2020, pp. 846-850. https://doi.org/10.1007/s11094-020-02285-w.