Pharmaceutical Chemistry Journal, volume 54, issue 8, pages 846-850

Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles

Publication typeJournal Article
Publication date2020-11-19
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor0.9
ISSN0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer nanoparticles and a protein vector (recombinant third domain of alpha-fetoprotein) was developed. Paclitaxel was determined at wavelength 260 ± 2 nm. The proposed method showed specificity, linearity (R2 = 0.9948) in the range 80 – 120% of paclitaxel nominal load in the polymer matrix (0.18 mg/mL), accuracy, and precision. The developed method could be recommended for inclusion in regulatory documentation for quality control of paclitaxel nanoparticles conjugated with a protein vector.

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Emergent Materials
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Emergent Materials
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Springer Nature
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Springer Nature
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Sokol M. B. et al. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
GOST all authors (up to 50) Copy
Sokol M. B., Sycheva Yu. V., Yabbarov N. G., Zabolotskii A. I., Mollaev M. D., Faustova M. R., Tereshchenko O. G., Fomicheva M. V., Nikolskaya E. D. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11094-020-02285-w
UR - https://doi.org/10.1007%2Fs11094-020-02285-w
TI - Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
T2 - Pharmaceutical Chemistry Journal
AU - Zabolotskii, A I
AU - Tereshchenko, O G
AU - Fomicheva, M V
AU - Nikolskaya, E D
AU - Sycheva, Yu V
AU - Yabbarov, N G
AU - Mollaev, M D
AU - Faustova, M R
AU - Sokol, M B
PY - 2020
DA - 2020/11/19 00:00:00
PB - Springer Nature
SP - 846-850
IS - 8
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
BibTex |
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@article{2020_Sokol
author = {A I Zabolotskii and O G Tereshchenko and M V Fomicheva and E D Nikolskaya and Yu V Sycheva and N G Yabbarov and M D Mollaev and M R Faustova and M B Sokol},
title = {Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles},
journal = {Pharmaceutical Chemistry Journal},
year = {2020},
volume = {54},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007%2Fs11094-020-02285-w},
number = {8},
pages = {846--850},
doi = {10.1007/s11094-020-02285-w}
}
MLA
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MLA Copy
Sokol, M. B., et al. “Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles.” Pharmaceutical Chemistry Journal, vol. 54, no. 8, Nov. 2020, pp. 846-850. https://doi.org/10.1007%2Fs11094-020-02285-w.
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