Pharmaceutical Chemistry Journal, volume 54, issue 8, pages 846-850
Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
Sokol M B
1, 2
,
Sycheva Yu V
1
,
Yabbarov N G
1, 2
,
Zabolotskii A I
1, 3
,
Mollaev M D
1, 4
,
Faustova M R
1, 2, 4
,
Tereshchenko O G
1
,
Fomicheva M V
1, 2
,
Nikolskaya E D
1, 2
1
Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2020-11-19
Journal:
Pharmaceutical Chemistry Journal
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 0.9
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer nanoparticles and a protein vector (recombinant third domain of alpha-fetoprotein) was developed. Paclitaxel was determined at wavelength 260 ± 2 nm. The proposed method showed specificity, linearity (R2 = 0.9948) in the range 80 – 120% of paclitaxel nominal load in the polymer matrix (0.18 mg/mL), accuracy, and precision. The developed method could be recommended for inclusion in regulatory documentation for quality control of paclitaxel nanoparticles conjugated with a protein vector.
Citations by journals
1
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Emergent Materials
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Emergent Materials
1 publication, 100%
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1
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Citations by publishers
1
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Springer Nature
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Springer Nature
1 publication, 100%
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1
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Sokol M. B. et al. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
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Sokol M. B., Sycheva Yu. V., Yabbarov N. G., Zabolotskii A. I., Mollaev M. D., Faustova M. R., Tereshchenko O. G., Fomicheva M. V., Nikolskaya E. D. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
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TY - JOUR
DO - 10.1007/s11094-020-02285-w
UR - https://doi.org/10.1007%2Fs11094-020-02285-w
TI - Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
T2 - Pharmaceutical Chemistry Journal
AU - Zabolotskii, A I
AU - Tereshchenko, O G
AU - Fomicheva, M V
AU - Nikolskaya, E D
AU - Sycheva, Yu V
AU - Yabbarov, N G
AU - Mollaev, M D
AU - Faustova, M R
AU - Sokol, M B
PY - 2020
DA - 2020/11/19 00:00:00
PB - Springer Nature
SP - 846-850
IS - 8
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2020_Sokol
author = {A I Zabolotskii and O G Tereshchenko and M V Fomicheva and E D Nikolskaya and Yu V Sycheva and N G Yabbarov and M D Mollaev and M R Faustova and M B Sokol},
title = {Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles},
journal = {Pharmaceutical Chemistry Journal},
year = {2020},
volume = {54},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007%2Fs11094-020-02285-w},
number = {8},
pages = {846--850},
doi = {10.1007/s11094-020-02285-w}
}
Cite this
MLA
Copy
Sokol, M. B., et al. “Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles.” Pharmaceutical Chemistry Journal, vol. 54, no. 8, Nov. 2020, pp. 846-850. https://doi.org/10.1007%2Fs11094-020-02285-w.