Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
M B Sokol
1, 2
,
Yu V Sycheva
1
,
N G Yabbarov
1, 2
,
A I Zabolotskii
1, 3
,
M D Mollaev
1, 4
,
M R Faustova
1, 2, 4
,
O G Tereshchenko
1
,
M V Fomicheva
1, 2
,
E D Nikolskaya
1, 2
1
Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2020-11-19
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer nanoparticles and a protein vector (recombinant third domain of alpha-fetoprotein) was developed. Paclitaxel was determined at wavelength 260 ± 2 nm. The proposed method showed specificity, linearity (R2 = 0.9948) in the range 80 – 120% of paclitaxel nominal load in the polymer matrix (0.18 mg/mL), accuracy, and precision. The developed method could be recommended for inclusion in regulatory documentation for quality control of paclitaxel nanoparticles conjugated with a protein vector.
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Sokol M. B. et al. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
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Sokol M. B., Sycheva Yu. V., Yabbarov N. G., Zabolotskii A. I., Mollaev M. D., Faustova M. R., Tereshchenko O. G., Fomicheva M. V., Nikolskaya E. D. Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles // Pharmaceutical Chemistry Journal. 2020. Vol. 54. No. 8. pp. 846-850.
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TY - JOUR
DO - 10.1007/s11094-020-02285-w
UR - https://doi.org/10.1007/s11094-020-02285-w
TI - Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
T2 - Pharmaceutical Chemistry Journal
AU - Sokol, M B
AU - Sycheva, Yu V
AU - Yabbarov, N G
AU - Zabolotskii, A I
AU - Mollaev, M D
AU - Faustova, M R
AU - Tereshchenko, O G
AU - Fomicheva, M V
AU - Nikolskaya, E D
PY - 2020
DA - 2020/11/19
PB - Springer Nature
SP - 846-850
IS - 8
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
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BibTex (up to 50 authors)
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@article{2020_Sokol,
author = {M B Sokol and Yu V Sycheva and N G Yabbarov and A I Zabolotskii and M D Mollaev and M R Faustova and O G Tereshchenko and M V Fomicheva and E D Nikolskaya},
title = {Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles},
journal = {Pharmaceutical Chemistry Journal},
year = {2020},
volume = {54},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s11094-020-02285-w},
number = {8},
pages = {846--850},
doi = {10.1007/s11094-020-02285-w}
}
Cite this
MLA
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Sokol, M. B., et al. “Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles.” Pharmaceutical Chemistry Journal, vol. 54, no. 8, Nov. 2020, pp. 846-850. https://doi.org/10.1007/s11094-020-02285-w.