An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
Publication type: Journal Article
Publication date: 2012-07-20
scimago Q1
wos Q1
SJR: 0.871
CiteScore: 6.8
Impact factor: 4.3
ISSN: 07248741, 1573904X
PubMed ID:
22814904
Organic Chemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Pharmacology (medical)
Biotechnology
Abstract
Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabilizers. Colchicine binding site inhibitors (CBSI) exert their biological effects by inhibiting tubulin assembly and suppressing microtubule formation. A large number of molecules interacting with the colchicine binding site have been designed and synthesized with significant structural diversity. CBSIs have been modified as to chemical structure as well as pharmacokinetic properties, and tested in order to find a highly potent, low toxicity agent for treatment of cancers. CBSIs are believed to act by a common mechanism via binding to the colchicine site on tubulin. The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in our understanding of the actions of CBSIs.
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Metrics
655
Total citations:
655
Citations from 2024:
88
(13.44%)
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GOST
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Lu Y. et al. An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site // Pharmaceutical Research. 2012. Vol. 29. No. 11. pp. 2943-2971.
GOST all authors (up to 50)
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Lu Y., Chen* J., Xiao M., Li W., Miller D. D. An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site // Pharmaceutical Research. 2012. Vol. 29. No. 11. pp. 2943-2971.
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RIS
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TY - JOUR
DO - 10.1007/s11095-012-0828-z
UR - https://doi.org/10.1007/s11095-012-0828-z
TI - An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
T2 - Pharmaceutical Research
AU - Lu, Yan
AU - Chen*, Jianjun
AU - Xiao, Min
AU - Li, Wei
AU - Miller, Duane D
PY - 2012
DA - 2012/07/20
PB - Springer Nature
SP - 2943-2971
IS - 11
VL - 29
PMID - 22814904
SN - 0724-8741
SN - 1573-904X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2012_Lu,
author = {Yan Lu and Jianjun Chen* and Min Xiao and Wei Li and Duane D Miller},
title = {An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site},
journal = {Pharmaceutical Research},
year = {2012},
volume = {29},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007/s11095-012-0828-z},
number = {11},
pages = {2943--2971},
doi = {10.1007/s11095-012-0828-z}
}
Cite this
MLA
Copy
Lu, Yan, et al. “An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site.” Pharmaceutical Research, vol. 29, no. 11, Jul. 2012, pp. 2943-2971. https://doi.org/10.1007/s11095-012-0828-z.