Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans
A.S Kulikov
1
,
M A Epishina
1
,
L V Batog
1
,
V Yu Rozhkov
1
,
N N Makhova
1
,
L D Konyushkin
1
,
M. N. Semenova
2
,
V. V. Semenov
1
Publication type: Journal Article
Publication date: 2013-03-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
PubMed ID:
32214776
General Chemistry
Abstract
A method of 3-amino-4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]furazan synthesis was optimized. Condensation of these compounds with 2,5-dimethoxytetrahydrofuran resulted in a series of previously unknown 4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]-3-(pyrrol-1-yl)furazans. All target compounds were evaluated for both antimitotic microtubule destabilizing effect in a phenotypic sea urchin embryo assay and cytotoxicity in a panel of 60 human cancer cell lines. Pyrrolyl derivatives of triazolylfurazans were determined as antiproliferative compounds. The most potent microtubule targeting compounds 7a and 7e are of interest for further trials as antineoplastic agents.
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Citations from 2025:
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Kulikov A. et al. Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans // Russian Chemical Bulletin. 2013. Vol. 62. No. 3. pp. 836-843.
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Kulikov A., Epishina M. A., Batog L. V., Rozhkov V. Yu., Makhova N. N., Konyushkin L. D., Semenova M. N., Semenov V. V. Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans // Russian Chemical Bulletin. 2013. Vol. 62. No. 3. pp. 836-843.
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TY - JOUR
DO - 10.1007/s11172-013-0113-2
UR - https://doi.org/10.1007/s11172-013-0113-2
TI - Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans
T2 - Russian Chemical Bulletin
AU - Kulikov, A.S
AU - Epishina, M A
AU - Batog, L V
AU - Rozhkov, V Yu
AU - Makhova, N N
AU - Konyushkin, L D
AU - Semenova, M. N.
AU - Semenov, V. V.
PY - 2013
DA - 2013/03/01
PB - Springer Nature
SP - 836-843
IS - 3
VL - 62
PMID - 32214776
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2013_Kulikov,
author = {A.S Kulikov and M A Epishina and L V Batog and V Yu Rozhkov and N N Makhova and L D Konyushkin and M. N. Semenova and V. V. Semenov},
title = {Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans},
journal = {Russian Chemical Bulletin},
year = {2013},
volume = {62},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s11172-013-0113-2},
number = {3},
pages = {836--843},
doi = {10.1007/s11172-013-0113-2}
}
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MLA
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Kulikov, A.S, et al. “Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans.” Russian Chemical Bulletin, vol. 62, no. 3, Mar. 2013, pp. 836-843. https://doi.org/10.1007/s11172-013-0113-2.