Springer Nature
Russian Chemical Bulletin
,  том 64 ,  издание 7 ,  страницы 1560-1563

Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs

Тип публикации: Journal Article
Дата публикации: 2015-07-01
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ISSN: 10665285, 15739171
General Chemistry
Краткое описание
A series of 2-aryl-5-arylmethylidene-1,3-oxazol-5(4H)-ones and 2-aryl-5-arylmethylidene-N-methyl-3,5-dihydro-4H-imidazol-4-ones was synthesized as structural analogs of combret- astatin A-4 (a compound possessing antitumor activity). (5Z)-5-[(4-Methoxyphenyl)methyl-idene]-3-methyl-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one was found to exhibit the highest cytotoxicity against cells of human A549 lung carcinoma line (EC50 = 6±0.8 μmol L−1).
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Barskaia E. S. et al. Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs // Russian Chemical Bulletin. 2015. Vol. 64. No. 7. pp. 1560-1563.
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Barskaia E. S., Beloglazkina A. A., Wobith B., Zefirov N. A., Majouga A. G., Beloglazkina E. K., Zyk N. V., Kuznetsov S. A., Zefirova O. N. Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs // Russian Chemical Bulletin. 2015. Vol. 64. No. 7. pp. 1560-1563.
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TY - JOUR
DO - 10.1007/s11172-015-1041-0
UR - http://link.springer.com/10.1007/s11172-015-1041-0
TI - Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs
T2 - Russian Chemical Bulletin
AU - Barskaia, E S
AU - Beloglazkina, A A
AU - Wobith, B
AU - Zefirov, N A
AU - Majouga, A G
AU - Beloglazkina, E K
AU - Zyk, N. V.
AU - Kuznetsov, S. A.
AU - Zefirova, O N
PY - 2015
DA - 2015/07/01
PB - Springer Nature
SP - 1560-1563
IS - 7
VL - 64
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2015_Barskaia,
author = {E S Barskaia and A A Beloglazkina and B Wobith and N A Zefirov and A G Majouga and E K Beloglazkina and N. V. Zyk and S. A. Kuznetsov and O N Zefirova},
title = {Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs},
journal = {Russian Chemical Bulletin},
year = {2015},
volume = {64},
publisher = {Springer Nature},
month = {jul},
url = {http://link.springer.com/10.1007/s11172-015-1041-0},
number = {7},
pages = {1560--1563},
doi = {10.1007/s11172-015-1041-0}
}
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Barskaia, E. S., et al. “Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs.” Russian Chemical Bulletin, vol. 64, no. 7, Jul. 2015, pp. 1560-1563. http://link.springer.com/10.1007/s11172-015-1041-0.