Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship
Тип публикации: Journal Article
Дата публикации: 2015-12-01
scimago Q3
БС2
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
A series of acyclic onium uracil derivatives was synthesized, including 1,3-bis[5-(alkyldiethylammonio)pentyl]-5(6)-substituted uracil dibromides and isostructural macrocyclic compounds (isomeric cis- and trans-pyrimidinophanes bearing onium groups in the decamethylene chains). The compounds were found to exhibit considerable bacteriostatic and fungistatic activity. The onium uracil derivatives were found to make a specific contribution to the antimicrobial action: the bacteriostatic and fungistatic activities of the compounds are determined by their topology, the nature of a substituent at atom C(5) of the uracil ring and a substituent in the onium group. The mechanism of antimicrobial action and cytotoxicity of uracil onium derivatives were studied.
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Semenov V. E. et al. Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship // Russian Chemical Bulletin. 2015. Vol. 64. No. 12. pp. 2885-2896.
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Semenov V. E., Voloshina A. D., Kulik N. V., Strobykina A. S., Giniyatullin R. Kh., Saifina L., Nikolaev A. E., Krylova E. S., Zobov V., Reznik V. Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship // Russian Chemical Bulletin. 2015. Vol. 64. No. 12. pp. 2885-2896.
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TY - JOUR
DO - 10.1007/s11172-015-1243-5
UR - https://doi.org/10.1007/s11172-015-1243-5
TI - Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship
T2 - Russian Chemical Bulletin
AU - Semenov, V E
AU - Voloshina, A D
AU - Kulik, N V
AU - Strobykina, A S
AU - Giniyatullin, R Kh
AU - Saifina, L.F.
AU - Nikolaev, A E
AU - Krylova, E S
AU - Zobov, V.V.
AU - Reznik, V.S.
PY - 2015
DA - 2015/12/01
PB - Springer Nature
SP - 2885-2896
IS - 12
VL - 64
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2015_Semenov,
author = {V E Semenov and A D Voloshina and N V Kulik and A S Strobykina and R Kh Giniyatullin and L.F. Saifina and A E Nikolaev and E S Krylova and V.V. Zobov and V.S. Reznik},
title = {Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship},
journal = {Russian Chemical Bulletin},
year = {2015},
volume = {64},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-015-1243-5},
number = {12},
pages = {2885--2896},
doi = {10.1007/s11172-015-1243-5}
}
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MLA
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Semenov, V. E., et al. “Macrocyclic and acyclic 1,3-bis[5-(trialkylammonio)pentyl]-5(6)-substituted uracil dibromides: synthesis, antimicrobial properties, and the structure—activity relationship.” Russian Chemical Bulletin, vol. 64, no. 12, Dec. 2015, pp. 2885-2896. https://doi.org/10.1007/s11172-015-1243-5.