Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins
S. D. Varfolomeev
1, 2
,
S V Lushchekina
1
,
A. V. Nemukhin
1, 2
,
A M Kulakova
2
,
E D Kots
1, 2
,
G. F. Makhaeva
3
,
H. Delacour
4
,
O Lockridge
5
,
P. MASSON
6
4
Department of Biology, Bégin Military Teaching Hospital, Saint Mandé, France
|
Publication type: Journal Article
Publication date: 2016-06-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular polymorphism on the activity of key human esterases, in particular, cholinesterases and carboxylesterase, responsible for hydrolytic metabolism of ester-containing drugs, is analyzed. A method was developed, which involves supercomputer-assisted modeling as a tool for assessment of molecular mechanism of the impact of point mutations on the catalytic activity of enzymes. This work is a part of a study aimed at elaboration of the concept and methods of personalized medicine.
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Total citations:
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Citations from 2024:
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(22%)
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GOST
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Varfolomeev S. D. et al. Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins // Russian Chemical Bulletin. 2016. Vol. 65. No. 6. pp. 1592-1607.
GOST all authors (up to 50)
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Varfolomeev S. D., Lushchekina S. V., Nemukhin A. V., Kulakova A. M., Kots E. D., Makhaeva G. F., Delacour H., Lockridge O., MASSON P. Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins // Russian Chemical Bulletin. 2016. Vol. 65. No. 6. pp. 1592-1607.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11172-016-1487-8
UR - https://doi.org/10.1007/s11172-016-1487-8
TI - Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins
T2 - Russian Chemical Bulletin
AU - Varfolomeev, S. D.
AU - Lushchekina, S V
AU - Nemukhin, A. V.
AU - Kulakova, A M
AU - Kots, E D
AU - Makhaeva, G. F.
AU - Delacour, H.
AU - Lockridge, O
AU - MASSON, P.
PY - 2016
DA - 2016/06/01
PB - Springer Nature
SP - 1592-1607
IS - 6
VL - 65
SN - 1066-5285
SN - 1573-9171
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Varfolomeev,
author = {S. D. Varfolomeev and S V Lushchekina and A. V. Nemukhin and A M Kulakova and E D Kots and G. F. Makhaeva and H. Delacour and O Lockridge and P. MASSON},
title = {Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins},
journal = {Russian Chemical Bulletin},
year = {2016},
volume = {65},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s11172-016-1487-8},
number = {6},
pages = {1592--1607},
doi = {10.1007/s11172-016-1487-8}
}
Cite this
MLA
Copy
Varfolomeev, S. D., et al. “Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins.” Russian Chemical Bulletin, vol. 65, no. 6, Jun. 2016, pp. 1592-1607. https://doi.org/10.1007/s11172-016-1487-8.
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