Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids
E D Nikolskaya
1
,
O A Zhunina
1
,
N G Yabbarov
1
,
V. A. Zenin
1
,
O G Tereshchenko
1
,
M V Fomicheva
1
,
M B Sokol
1
,
A. V. Lobanov
2
,
E S. Severin
1
1
OJSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation
|
Publication type: Journal Article
Publication date: 2017-10-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Polymer particles containing carboplatin (CPt) were developed by the inclusion of this antitumor agent in a copolymer of lactic and glycolic acids (PLGA-COOH 50/50). The polymer particles were found to have a spherical form with an average diameter not exceeding 200 nm, the ζ-potential is equal to–32.2±1 mV. The CPt-loaded polymer particles possess a cytotoxic activity against human small cell and non-small cell lung carcinoma (lines H69 and A549), as well as against mouse mammary adenocarcinoma (line Ca755). The results of the in vivo studies carried out on female mice of line C57Bl/6 with inoculated mouse melanoma of line B16 showed increasing of lifespan of the animals and inhibition of tumor growth for groups treated with the polymer particles, as compared to the animals treated with the drug substance CPt.
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Nikolskaya E. D. et al. Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids // Russian Chemical Bulletin. 2017. Vol. 66. No. 10. pp. 1867-1872.
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Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Zenin V. A., Tereshchenko O. G., Fomicheva M. V., Sokol M. B., Lobanov A. V., Severin E. S. Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids // Russian Chemical Bulletin. 2017. Vol. 66. No. 10. pp. 1867-1872.
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TY - JOUR
DO - 10.1007/s11172-017-1959-5
UR - https://doi.org/10.1007/s11172-017-1959-5
TI - Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids
T2 - Russian Chemical Bulletin
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Zenin, V. A.
AU - Tereshchenko, O G
AU - Fomicheva, M V
AU - Sokol, M B
AU - Lobanov, A. V.
AU - Severin, E S.
PY - 2017
DA - 2017/10/01
PB - Springer Nature
SP - 1867-1872
IS - 10
VL - 66
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2017_Nikolskaya,
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and V. A. Zenin and O G Tereshchenko and M V Fomicheva and M B Sokol and A. V. Lobanov and E S. Severin},
title = {Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids},
journal = {Russian Chemical Bulletin},
year = {2017},
volume = {66},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s11172-017-1959-5},
number = {10},
pages = {1867--1872},
doi = {10.1007/s11172-017-1959-5}
}
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MLA
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Nikolskaya, E. D., et al. “Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids.” Russian Chemical Bulletin, vol. 66, no. 10, Oct. 2017, pp. 1867-1872. https://doi.org/10.1007/s11172-017-1959-5.