Russian Chemical Bulletin, volume 66, issue 10, pages 1867-1872
Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids
Nikolskaya E D
1
,
Zhunina O A
1
,
Yabbarov N G
1
,
Zenin V. A.
1
,
Tereshchenko O G
1
,
Fomicheva M V
1
,
Sokol M B
1
,
Lobanov A. V.
2
,
Severin E S.
1
1
OJSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation
|
Publication type: Journal Article
Publication date: 2017-10-01
Journal:
Russian Chemical Bulletin
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.7
ISSN: 10665285, 15739171
General Chemistry
Abstract
Polymer particles containing carboplatin (CPt) were developed by the inclusion of this antitumor agent in a copolymer of lactic and glycolic acids (PLGA-COOH 50/50). The polymer particles were found to have a spherical form with an average diameter not exceeding 200 nm, the ζ-potential is equal to–32.2±1 mV. The CPt-loaded polymer particles possess a cytotoxic activity against human small cell and non-small cell lung carcinoma (lines H69 and A549), as well as against mouse mammary adenocarcinoma (line Ca755). The results of the in vivo studies carried out on female mice of line C57Bl/6 with inoculated mouse melanoma of line B16 showed increasing of lifespan of the animals and inhibition of tumor growth for groups treated with the polymer particles, as compared to the animals treated with the drug substance CPt.
Citations by journals
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1
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Russian Chemical Bulletin
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Russian Chemical Bulletin
1 publication, 50%
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Physics of Atomic Nuclei
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Physics of Atomic Nuclei
1 publication, 50%
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1
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Citations by publishers
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1
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Springer Nature
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Springer Nature
1 publication, 50%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 50%
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1
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Nikolskaya E. D. et al. Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids // Russian Chemical Bulletin. 2017. Vol. 66. No. 10. pp. 1867-1872.
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Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Zenin V. A., Tereshchenko O. G., Fomicheva M. V., Sokol M. B., Lobanov A. V., Severin E. S. Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids // Russian Chemical Bulletin. 2017. Vol. 66. No. 10. pp. 1867-1872.
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TY - JOUR
DO - 10.1007/s11172-017-1959-5
UR - https://doi.org/10.1007%2Fs11172-017-1959-5
TI - Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids
T2 - Russian Chemical Bulletin
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Zenin, V. A.
AU - Tereshchenko, O G
AU - Fomicheva, M V
AU - Lobanov, A. V.
AU - Severin, E S.
AU - Sokol, M B
PY - 2017
DA - 2017/10/01 00:00:00
PB - Springer Nature
SP - 1867-1872
IS - 10
VL - 66
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2017_Nikolskaya,
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and V. A. Zenin and O G Tereshchenko and M V Fomicheva and A. V. Lobanov and E S. Severin and M B Sokol},
title = {Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids},
journal = {Russian Chemical Bulletin},
year = {2017},
volume = {66},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007%2Fs11172-017-1959-5},
number = {10},
pages = {1867--1872},
doi = {10.1007/s11172-017-1959-5}
}
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MLA
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Nikolskaya, E. D., et al. “Antitumor activity of carboplatin in the composition of a copolymer of lactic and glycolic acids.” Russian Chemical Bulletin, vol. 66, no. 10, Oct. 2017, pp. 1867-1872. https://doi.org/10.1007%2Fs11172-017-1959-5.