Russian Chemical Bulletin

, том 67 , издание 4 , страницы 747-756

Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance

Тип публикации: Journal Article

Дата публикации: 2018-04-01

Springer Nature

Russian Chemical Bulletin

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БС2

SJR: 0.305

CiteScore: 2.8

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ISSN: 10665285, 15739171

DOI: 10.1007/s11172-018-2132-5

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General Chemistry

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Method for the synthesis of polymeric nanoparticles (NP) with encapsulated daunorubicin (DNR) was developed on the basis of double emulsion solvent evaporation technique using biodegradable poly(lactide-co-glycolide) (PLGA), which is aimed at customization of pharmacokinetic properties of the preparation, enhanced accumulation of DNR in tumor cells and prolongation of its action. The obtained polymer nanoparticles (DNR-PLGA) had average size ranging around 138±36 nm, with zeta-potential of –25.3 mV and the polydispersity index (PDI) of 0.072. The release kinetics of DNR from polymer nanoparticles at pH 7.4 and 5.0 has been studied. In vitro studies showed similar specific activity of DNR- PLGA in K562 and MCF-7 cancer cell lines together with an increase in activity in K562 Adr and MCF-7 Adr cell lines, which are anthracycline resistant, by 1.6 and 3.4 times. The study demonstrated the efficacy of the developed PLGA-based DNR delivery system in the improvement of antitumor effect of DNR, overcoming multidrug resistance in cancer cells, and also in the decrease in nonspecific toxicity of the preparation.

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Никольская Елена

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Институт биохимической физики им. Н.М. Эмануэля РАН

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Current Pharmaceutical Design	Current Pharmaceutical Design, 1, 12.5% Current Pharmaceutical Design 1 публикация, 12.5%
Russian Chemical Bulletin	Russian Chemical Bulletin, 1, 12.5% Russian Chemical Bulletin 1 публикация, 12.5%
Critical Reviews in Therapeutic Drug Carrier Systems	Critical Reviews in Therapeutic Drug Carrier Systems, 1, 12.5% Critical Reviews in Therapeutic Drug Carrier Systems 1 публикация, 12.5%
Antibiotiki i Khimioterapiya	Antibiotiki i Khimioterapiya, 1, 12.5% Antibiotiki i Khimioterapiya 1 публикация, 12.5%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 12.5% Biochemistry (Moscow) 1 публикация, 12.5%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 1, 12.5% Biochemical and Biophysical Research Communications 1 публикация, 12.5%
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Nikolskaya E. D. et al. Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance // Russian Chemical Bulletin. 2018. Vol. 67. No. 4. pp. 747-756.

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Nikolskaya E. D., Faustova M. R., Mollaev M. D., Zhunina O. A., Sokol M. B., Yabbarov N. G., Gukasova N. V., Lobanov A. V., Shvets V. I., Severin E. S. Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance // Russian Chemical Bulletin. 2018. Vol. 67. No. 4. pp. 747-756.

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TY - JOUR

DO - 10.1007/s11172-018-2132-5

UR - https://doi.org/10.1007/s11172-018-2132-5

TI - Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance

T2 - Russian Chemical Bulletin

AU - Nikolskaya, E D

AU - Faustova, M R

AU - Mollaev, M D

AU - Zhunina, O A

AU - Sokol, M B

AU - Yabbarov, N G

AU - Gukasova, N V

AU - Lobanov, A. V.

AU - Shvets, V. I.

AU - Severin, E S.

PY - 2018

DA - 2018/04/01

PB - Springer Nature

SP - 747-756

IS - 4

VL - 67

SN - 1066-5285

SN - 1573-9171

ER -

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@article{2018_Nikolskaya,

author = {E D Nikolskaya and M R Faustova and M D Mollaev and O A Zhunina and M B Sokol and N G Yabbarov and N V Gukasova and A. V. Lobanov and V. I. Shvets and E S. Severin},

title = {Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance},

journal = {Russian Chemical Bulletin},

year = {2018},

volume = {67},

publisher = {Springer Nature},

month = {apr},

url = {https://doi.org/10.1007/s11172-018-2132-5},

number = {4},

pages = {747--756},

doi = {10.1007/s11172-018-2132-5}

}

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Nikolskaya, E. D., et al. “Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance.” Russian Chemical Bulletin, vol. 67, no. 4, Apr. 2018, pp. 747-756. https://doi.org/10.1007/s11172-018-2132-5.