Springer Nature
Russian Chemical Bulletin
,  volume 67 ,  issue 4 ,  pages 747-756

Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance

Publication type: Journal Article
Publication date: 2018-04-01
Springer Nature
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Method for the synthesis of polymeric nanoparticles (NP) with encapsulated daunorubicin (DNR) was developed on the basis of double emulsion solvent evaporation technique using biodegradable poly(lactide-co-glycolide) (PLGA), which is aimed at customization of pharmacokinetic properties of the preparation, enhanced accumulation of DNR in tumor cells and prolongation of its action. The obtained polymer nanoparticles (DNR-PLGA) had average size ranging around 138±36 nm, with zeta-potential of –25.3 mV and the polydispersity index (PDI) of 0.072. The release kinetics of DNR from polymer nanoparticles at pH 7.4 and 5.0 has been studied. In vitro studies showed similar specific activity of DNR- PLGA in K562 and MCF-7 cancer cell lines together with an increase in activity in K562 Adr and MCF-7 Adr cell lines, which are anthracycline resistant, by 1.6 and 3.4 times. The study demonstrated the efficacy of the developed PLGA-based DNR delivery system in the improvement of antitumor effect of DNR, overcoming multidrug resistance in cancer cells, and also in the decrease in nonspecific toxicity of the preparation.
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GOST Copy
Nikolskaya E. D. et al. Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance // Russian Chemical Bulletin. 2018. Vol. 67. No. 4. pp. 747-756.
GOST all authors (up to 50) Copy
Nikolskaya E. D., Faustova M. R., Mollaev M. D., Zhunina O. A., Sokol M. B., Yabbarov N. G., Gukasova N. V., Lobanov A. V., Shvets V. I., Severin E. S. Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance // Russian Chemical Bulletin. 2018. Vol. 67. No. 4. pp. 747-756.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11172-018-2132-5
UR - https://doi.org/10.1007/s11172-018-2132-5
TI - Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance
T2 - Russian Chemical Bulletin
AU - Nikolskaya, E D
AU - Faustova, M R
AU - Mollaev, M D
AU - Zhunina, O A
AU - Sokol, M B
AU - Yabbarov, N G
AU - Gukasova, N V
AU - Lobanov, A. V.
AU - Shvets, V. I.
AU - Severin, E S.
PY - 2018
DA - 2018/04/01
PB - Springer Nature
SP - 747-756
IS - 4
VL - 67
SN - 1066-5285
SN - 1573-9171
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Nikolskaya,
author = {E D Nikolskaya and M R Faustova and M D Mollaev and O A Zhunina and M B Sokol and N G Yabbarov and N V Gukasova and A. V. Lobanov and V. I. Shvets and E S. Severin},
title = {Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance},
journal = {Russian Chemical Bulletin},
year = {2018},
volume = {67},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007/s11172-018-2132-5},
number = {4},
pages = {747--756},
doi = {10.1007/s11172-018-2132-5}
}
MLA
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MLA Copy
Nikolskaya, E. D., et al. “Development of a polymer system for the delivery of daunorubicin to tumor cells to overcome drug resistance.” Russian Chemical Bulletin, vol. 67, no. 4, Apr. 2018, pp. 747-756. https://doi.org/10.1007/s11172-018-2132-5.