Springer Nature
Russian Chemical Bulletin
,  том 67 ,  издание 12 ,  страницы 2290-2296

Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid

Тип публикации: Journal Article
Дата публикации: 2018-12-01
Springer Nature
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SJR: 0.272
CiteScore: 2.8
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ISSN: 10665285, 15739171
General Chemistry
Краткое описание
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
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Tereshchenko O. G. et al. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.
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Tereshchenko O. G., Nikolskaya E. D., Zhunina O. A., Zavarzina V. V., Yabbarov N. G., Fomicheva M. V., Zubkov E. V., Sokol M. B., Gukasova N. V., Severin E. S. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.
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TY - JOUR
DO - 10.1007/s11172-018-2372-4
UR - https://doi.org/10.1007/s11172-018-2372-4
TI - Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
T2 - Russian Chemical Bulletin
AU - Tereshchenko, O G
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Zavarzina, V V
AU - Yabbarov, N G
AU - Fomicheva, M V
AU - Zubkov, E V
AU - Sokol, M B
AU - Gukasova, N V
AU - Severin, E S.
PY - 2018
DA - 2018/12/01
PB - Springer Nature
SP - 2290-2296
IS - 12
VL - 67
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2018_Tereshchenko,
author = {O G Tereshchenko and E D Nikolskaya and O A Zhunina and V V Zavarzina and N G Yabbarov and M V Fomicheva and E V Zubkov and M B Sokol and N V Gukasova and E S. Severin},
title = {Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid},
journal = {Russian Chemical Bulletin},
year = {2018},
volume = {67},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-018-2372-4},
number = {12},
pages = {2290--2296},
doi = {10.1007/s11172-018-2372-4}
}
MLA
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Tereshchenko, O. G., et al. “Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid.” Russian Chemical Bulletin, vol. 67, no. 12, Dec. 2018, pp. 2290-2296. https://doi.org/10.1007/s11172-018-2372-4.
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