Springer Nature
Russian Chemical Bulletin
,  volume 67 ,  issue 12 ,  pages 2290-2296

Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid

O G Tereshchenko 1
, 
E D Nikolskaya 1
, 
O A Zhunina 1
, 
V V Zavarzina 2
, 
N G Yabbarov 1
, 
M V Fomicheva 1
, 
E V Zubkov 1, 3
, 
M B Sokol 1
, 
N V Gukasova 2
, 
E S. Severin 1
1
 
Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation | 
2
 
3
 
Publication type: Journal Article
Publication date: 2018-12-01
Springer Nature
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
Found 
Found 

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GOST Copy
Tereshchenko O. G. et al. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.
GOST all authors (up to 50) Copy
Tereshchenko O. G., Nikolskaya E. D., Zhunina O. A., Zavarzina V. V., Yabbarov N. G., Fomicheva M. V., Zubkov E. V., Sokol M. B., Gukasova N. V., Severin E. S. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s11172-018-2372-4
UR - https://doi.org/10.1007/s11172-018-2372-4
TI - Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
T2 - Russian Chemical Bulletin
AU - Tereshchenko, O G
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Zavarzina, V V
AU - Yabbarov, N G
AU - Fomicheva, M V
AU - Zubkov, E V
AU - Sokol, M B
AU - Gukasova, N V
AU - Severin, E S.
PY - 2018
DA - 2018/12/01
PB - Springer Nature
SP - 2290-2296
IS - 12
VL - 67
SN - 1066-5285
SN - 1573-9171
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Tereshchenko,
author = {O G Tereshchenko and E D Nikolskaya and O A Zhunina and V V Zavarzina and N G Yabbarov and M V Fomicheva and E V Zubkov and M B Sokol and N V Gukasova and E S. Severin},
title = {Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid},
journal = {Russian Chemical Bulletin},
year = {2018},
volume = {67},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-018-2372-4},
number = {12},
pages = {2290--2296},
doi = {10.1007/s11172-018-2372-4}
}
MLA
Cite this
MLA Copy
Tereshchenko, O. G., et al. “Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid.” Russian Chemical Bulletin, vol. 67, no. 12, Dec. 2018, pp. 2290-2296. https://doi.org/10.1007/s11172-018-2372-4.