Russian Chemical Bulletin, volume 67, issue 12, pages 2290-2296

Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid

Tereshchenko O G ¹

Nikolskaya E D ¹

Zhunina O A ¹

Zavarzina V V ²

Yabbarov N G ¹

Fomicheva M V ¹

Zubkov E V ^{1, 3}

Sokol M B ¹

Gukasova N V ²

Severin E S. ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation |

National Research Center “Kurchatov Institute”, Moscow, Russian Federation |

Sechenov University, Ministry of Health of the Russian Federation, Moscow, Russian Federation |

Publication type: Journal Article

Publication date: 2018-12-01

Springer Nature

Journal: Russian Chemical Bulletin

Quartile SCImago

Quartile WOS

Impact factor: 1.7

ISSN: 10665285, 15739171

DOI: 10.1007/s11172-018-2372-4

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General Chemistry

Abstract

Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.

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Citations by journals

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Nanobiotechnology Reports	Nanobiotechnology Reports, 2, 28.57% Nanobiotechnology Reports 2 publications, 28.57%
Drug development & registration	Drug development & registration, 1, 14.29% Drug development & registration 1 publication, 14.29%
Pharmaceutics	Pharmaceutics, 1, 14.29% Pharmaceutics 1 publication, 14.29%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 14.29% Colloids and Surfaces B: Biointerfaces 1 publication, 14.29%
Journal of Healthcare Engineering	Journal of Healthcare Engineering, 1, 14.29% Journal of Healthcare Engineering 1 publication, 14.29%
Agrarian science	Agrarian science, 1, 14.29% Agrarian science 1 publication, 14.29%
	1 2

Citations by publishers

	1 2
Pleiades Publishing	Pleiades Publishing, 2, 28.57% Pleiades Publishing 2 publications, 28.57%
Center of Pharmaceutical Analytics Ltd	Center of Pharmaceutical Analytics Ltd, 1, 14.29% Center of Pharmaceutical Analytics Ltd 1 publication, 14.29%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 14.29% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 14.29%
Elsevier	Elsevier, 1, 14.29% Elsevier 1 publication, 14.29%
Hindawi Limited	Hindawi Limited, 1, 14.29% Hindawi Limited 1 publication, 14.29%
Agrarian Science	Agrarian Science, 1, 14.29% Agrarian Science 1 publication, 14.29%
	1 2

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Tereshchenko O. G. et al. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.

GOST all authors (up to 50) Copy

Tereshchenko O. G., Nikolskaya E. D., Zhunina O. A., Zavarzina V. V., Yabbarov N. G., Fomicheva M. V., Zubkov E. V., Sokol M. B., Gukasova N. V., Severin E. S. Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid // Russian Chemical Bulletin. 2018. Vol. 67. No. 12. pp. 2290-2296.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s11172-018-2372-4

UR - https://doi.org/10.1007%2Fs11172-018-2372-4

TI - Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid

T2 - Russian Chemical Bulletin

AU - Tereshchenko, O G

AU - Nikolskaya, E D

AU - Zhunina, O A

AU - Zavarzina, V V

AU - Yabbarov, N G

AU - Fomicheva, M V

AU - Zubkov, E V

AU - Gukasova, N V

AU - Severin, E S.

AU - Sokol, M B

PY - 2018

DA - 2018/12/01 00:00:00

PB - Springer Nature

SP - 2290-2296

IS - 12

VL - 67

SN - 1066-5285

SN - 1573-9171

ER -

BibTex |

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BibTex Copy

@article{2018_Tereshchenko,

author = {O G Tereshchenko and E D Nikolskaya and O A Zhunina and V V Zavarzina and N G Yabbarov and M V Fomicheva and E V Zubkov and N V Gukasova and E S. Severin and M B Sokol},

title = {Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid},

journal = {Russian Chemical Bulletin},

year = {2018},

volume = {67},

publisher = {Springer Nature},

month = {dec},

url = {https://doi.org/10.1007%2Fs11172-018-2372-4},

number = {12},

pages = {2290--2296},

doi = {10.1007/s11172-018-2372-4}

}

MLA

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MLA Copy

Tereshchenko, O. G., et al. “Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid.” Russian Chemical Bulletin, vol. 67, no. 12, Dec. 2018, pp. 2290-2296. https://doi.org/10.1007%2Fs11172-018-2372-4.

Found error?

Publisher

Springer Nature

Journal

Russian Chemical Bulletin

Quartile SCImago

Quartile WOS

Impact factor

1.7

ISSN

10665285 (Print)
15739171 (Electronic)

Labs

Laboratory of Biotechnologies and Nanostructures for targeted drug delivery

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