Russian Chemical Bulletin

, volume 68 , issue 5 , pages 1006-1013

Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity

A A Beloglazkina ¹

N A Karpov ¹

S R Mefedova ¹

V S Polyakov ¹

D A Skvortsov ¹

M A Kalinina ^{1, 2}

V. A. Tafeenko ¹

A G Majouga ^{1, 3}

N. V. Zyk ¹

E K Beloglazkina ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russian Federation |

Skolkovo Institute of Science and Technology, Territory of the Skolkovo Innovation Center, Moscow, Russian Federation |

D. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation |

Publication type: Journal Article

Publication date: 2019-05-01

Springer Nature

Russian Chemical Bulletin

scimago Q3

SJR: 0.305

CiteScore: 2.8

Impact factor: —

ISSN: 10665285, 15739171

DOI: 10.1007/s11172-019-2511-6

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General Chemistry

Abstract

A convenient method is proposed for the synthesis of N-unsubstituted spiroxindoles with different heterocyclic moieties (2-thiohydantoin, hydantoin, and thiazolidine) by the regio-selective 1,3-dipolar cycloaddition of azomethine ylides, generated from isatins and sarcosine, to arylidene derivatives of corresponding heterocycles. The cytotoxicity of compounds was tested by the MTT method against MCF7, A549, HEK, and VA13 cell lines and compared with the anticancer drug Nutlin-3a. The best bioactivity was observed for hydantoin-based dispiroindolinones, the most cytotoxic compound demonstrated selectivity against A549 lung cancer cells with an IC50 value of 6.6±1.6 μmol L−1.

Found

10 citations

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 214 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

5 citations

Skvortsov Dmitry

🥼

PhD in Chemistry

128 publications, 1 834 citations, 1 review

h-index: 26

Lomonosov Moscow State University

2 citations

Izmest'ev Alexei

PhD in Chemistry

33 publications, 306 citations

h-index: 12

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

1 citation

Finko Alexander

PhD in Chemistry, associate professor

49 publications, 225 citations, 2 reviews

h-index: 8

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Lomonosov Moscow State University

1 citation

Borisov Roman

🤝

PhD in Chemistry

184 publications, 1 708 citations, 19 reviews

h-index: 20

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Peoples' Friendship University of Russia

Research interests

Mass Spectrometry

1 citation

Babaeva Olga

PhD in Chemistry

56 publications, 436 citations

h-index: 12

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Organic Chemistry

Physical Chemistry

1 citation

Islamov Daut

PhD

168 publications, 1 549 citations

h-index: 20

Kazan Scientific Center of the Russian Academy of Sciences

Research interests

X-ray diffraction analysis

1 citation

Chmelyuk Nelly

25 publications, 201 citations

h-index: 8

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

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Beloglazkina A. A. et al. Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1006-1013.

GOST all authors (up to 50) Copy

Beloglazkina A. A., Karpov N. A., Mefedova S. R., Polyakov V. S., Skvortsov D. A., Kalinina M. A., Tafeenko V. A., Majouga A. G., Zyk N. V., Beloglazkina E. K. Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1006-1013.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s11172-019-2511-6

UR - http://link.springer.com/10.1007/s11172-019-2511-6

TI - Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity

T2 - Russian Chemical Bulletin

AU - Beloglazkina, A A

AU - Karpov, N A

AU - Mefedova, S R

AU - Polyakov, V S

AU - Skvortsov, D A

AU - Kalinina, M A

AU - Tafeenko, V. A.

AU - Majouga, A G

AU - Zyk, N. V.

AU - Beloglazkina, E K

PY - 2019

DA - 2019/05/01

PB - Springer Nature

SP - 1006-1013

IS - 5

VL - 68

SN - 1066-5285

SN - 1573-9171

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Beloglazkina,

author = {A A Beloglazkina and N A Karpov and S R Mefedova and V S Polyakov and D A Skvortsov and M A Kalinina and V. A. Tafeenko and A G Majouga and N. V. Zyk and E K Beloglazkina},

title = {Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity},

journal = {Russian Chemical Bulletin},

year = {2019},

volume = {68},

publisher = {Springer Nature},

month = {may},

url = {http://link.springer.com/10.1007/s11172-019-2511-6},

number = {5},

pages = {1006--1013},

doi = {10.1007/s11172-019-2511-6}

}

MLA

Cite this

MLA Copy

Beloglazkina, A. A., et al. “Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity.” Russian Chemical Bulletin, vol. 68, no. 5, May. 2019, pp. 1006-1013. http://link.springer.com/10.1007/s11172-019-2511-6.

Publisher

Springer Nature

Journal

Russian Chemical Bulletin

scimago Q3

SJR

0.305

CiteScore

2.8

Impact factor

—

ISSN

10665285 (Print)

15739171 (Electronic)

Labs

Laboratory of Biologically Active Organic Compounds (BAOС)

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