Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity
Тип публикации: Journal Article
Дата публикации: 2019-05-01
scimago Q3
БС2
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
A convenient method is proposed for the synthesis of N-unsubstituted spiroxindoles with different heterocyclic moieties (2-thiohydantoin, hydantoin, and thiazolidine) by the regio-selective 1,3-dipolar cycloaddition of azomethine ylides, generated from isatins and sarcosine, to arylidene derivatives of corresponding heterocycles. The cytotoxicity of compounds was tested by the MTT method against MCF7, A549, HEK, and VA13 cell lines and compared with the anticancer drug Nutlin-3a. The best bioactivity was observed for hydantoin-based dispiroindolinones, the most cytotoxic compound demonstrated selectivity against A549 lung cancer cells with an IC50 value of 6.6±1.6 μmol L−1.
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Beloglazkina A. A. et al. Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1006-1013.
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Beloglazkina A. A., Karpov N. A., Mefedova S. R., Polyakov V. S., Skvortsov D. A., Kalinina M. A., Tafeenko V. A., Majouga A. G., Zyk N. V., Beloglazkina E. K. Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1006-1013.
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TY - JOUR
DO - 10.1007/s11172-019-2511-6
UR - http://link.springer.com/10.1007/s11172-019-2511-6
TI - Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity
T2 - Russian Chemical Bulletin
AU - Beloglazkina, A A
AU - Karpov, N A
AU - Mefedova, S R
AU - Polyakov, V S
AU - Skvortsov, D A
AU - Kalinina, M A
AU - Tafeenko, V. A.
AU - Majouga, A G
AU - Zyk, N. V.
AU - Beloglazkina, E K
PY - 2019
DA - 2019/05/01
PB - Springer Nature
SP - 1006-1013
IS - 5
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2019_Beloglazkina,
author = {A A Beloglazkina and N A Karpov and S R Mefedova and V S Polyakov and D A Skvortsov and M A Kalinina and V. A. Tafeenko and A G Majouga and N. V. Zyk and E K Beloglazkina},
title = {Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {may},
url = {http://link.springer.com/10.1007/s11172-019-2511-6},
number = {5},
pages = {1006--1013},
doi = {10.1007/s11172-019-2511-6}
}
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MLA
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Beloglazkina, A. A., et al. “Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity.” Russian Chemical Bulletin, vol. 68, no. 5, May. 2019, pp. 1006-1013. http://link.springer.com/10.1007/s11172-019-2511-6.