Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo

Faustova M.R., Nikolskaya E.D., Mollaev M.D., Sokol M.B., Zabolotsky A.I., Zhunina O.A., Fomicheva M.V., Schvets V.I., Lobanov A.V., Yabbarov N.G.
Тип документаJournal Article
Дата публикации2019-12-25
Название журналаRussian Chemical Bulletin
ИздательSpringer Nature
Квартиль по SCImagoQ3
Квартиль по Web of ScienceQ4
Импакт-фактор 20211.70
ISSN10665285, 15739171
General Chemistry
Краткое описание
Reactive oxygen species are generated by the redox reaction involving metalloporphyrin and ascorbic acid (AA) and lead to oxidative stress followed by cancer cell death. Polymer particles based on the copolymer of lactic and glycolic acid (PLGA) containing FeIIICl-tetraphenylporphyrin (FeClTPP) were prepared and characterized. These particles in combination with AA exhibit cytotoxic activity against the K562 (human chronic myelogenous leukemia) and MCF7 (human breast adenocarcinoma) cell lines. Results in vitro indicated significant antitumor efficiency on mice inoculated with P388 leukemic cells and treated with FeClTPP/AA. The cytotoxic activity of the combined system is achieved due to the formation of reactive oxygen species. The application of this system to the study of anticancer efficiency in vivo on the model of mice that were hypodermically inoculated with P388 lymphocytic leukemia revealed a significant inhibition of tumor growth. The use of FeClTPP in combination with AA seems to be promising in cancer treatment.
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1. Faustova M. R. и др. Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo // Russian Chemical Bulletin. 2019. Т. 68. № 12. С. 2216–2224.


DO - 10.1007/s11172-019-2690-1

UR - http://dx.doi.org/10.1007/s11172-019-2690-1

TI - Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo

T2 - Russian Chemical Bulletin

AU - Faustova, M. R.

AU - Nikolskaya, E. D.

AU - Mollaev, M. D.

AU - Sokol, M. B.

AU - Zabolotsky, A. I.

AU - Zhunina, O. A.

AU - Fomicheva, M. V.

AU - Schvets, V. I.

AU - Lobanov, A. V.

AU - Yabbarov, N. G.

PY - 2019

DA - 2019/12

PB - Springer Science and Business Media LLC

SP - 2216-2224

IS - 12

VL - 68

SN - 1066-5285

SN - 1573-9171

ER -

BibTex |


doi = {10.1007/s11172-019-2690-1},

url = {https://doi.org/10.1007%2Fs11172-019-2690-1},

year = 2019,

month = {dec},

publisher = {Springer Science and Business Media {LLC}},

volume = {68},

number = {12},

pages = {2216--2224},

author = {M. R. Faustova and E. D. Nikolskaya and M. D. Mollaev and M. B. Sokol and A. I. Zabolotsky and O. A. Zhunina and M. V. Fomicheva and V. I. Schvets and A. V. Lobanov and N. G. Yabbarov},

title = {Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo},

journal = {Russian Chemical Bulletin}


Faustova, M. R., et al. “Polymer Particles Containing Fe-Based Metalloporphyrin as a Highly Efficient Stimulator of Reactive Oxygen Species Formation in Vitro and in Vivo.” Russian Chemical Bulletin, vol. 68, no. 12, Dec. 2019, pp. 2216–24. Crossref, https://doi.org/10.1007/s11172-019-2690-1.