Russian Chemical Bulletin, том 68, издание 12, страницы 2216-2224

Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo

Faustova M R 1, 2
Nikolskaya E D 1, 3
Mollaev M D 2
Sokol M B 1
Zabolotsky A I 1
Zhunina O A 1, 3
Fomicheva M V 1
Schvets V I 2
Lobanov A. V. 3
Тип публикацииJournal Article
Дата публикации2019-12-01
Квартиль SCImago
Q3
Квартиль WOS
Q3
Impact factor1.7
ISSN10665285, 15739171
General Chemistry
Краткое описание
Reactive oxygen species are generated by the redox reaction involving metalloporphyrin and ascorbic acid (AA) and lead to oxidative stress followed by cancer cell death. Polymer particles based on the copolymer of lactic and glycolic acid (PLGA) containing FeIIICl-tetraphenylporphyrin (FeClTPP) were prepared and characterized. These particles in combination with AA exhibit cytotoxic activity against the K562 (human chronic myelogenous leukemia) and MCF7 (human breast adenocarcinoma) cell lines. Results in vitro indicated significant antitumor efficiency on mice inoculated with P388 leukemic cells and treated with FeClTPP/AA. The cytotoxic activity of the combined system is achieved due to the formation of reactive oxygen species. The application of this system to the study of anticancer efficiency in vivo on the model of mice that were hypodermically inoculated with P388 lymphocytic leukemia revealed a significant inhibition of tumor growth. The use of FeClTPP in combination with AA seems to be promising in cancer treatment.

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Pharmaceutics
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Pharmaceutics
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
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Russian Chemical Bulletin
Russian Chemical Bulletin, 1, 20%
Russian Chemical Bulletin
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Polymers
Polymers, 1, 20%
Polymers
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Multidisciplinary Digital Publishing Institute (MDPI)
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ГОСТ |
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Faustova M. R. et al. Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2216-2224.
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Faustova M. R., Nikolskaya E. D., Mollaev M. D., Sokol M. B., Zabolotsky A. I., Zhunina O. A., Fomicheva M. V., Schvets V. I., Lobanov A. V., Yabbarov N. G. Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2216-2224.
RIS |
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TY - JOUR
DO - 10.1007/s11172-019-2690-1
UR - https://doi.org/10.1007/s11172-019-2690-1
TI - Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo
T2 - Russian Chemical Bulletin
AU - Faustova, M R
AU - Nikolskaya, E D
AU - Mollaev, M D
AU - Zabolotsky, A I
AU - Zhunina, O A
AU - Fomicheva, M V
AU - Schvets, V I
AU - Lobanov, A. V.
AU - Yabbarov, N G
AU - Sokol, M B
PY - 2019
DA - 2019/12/01 00:00:00
PB - Springer Nature
SP - 2216-2224
IS - 12
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
BibTex |
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@article{2019_Faustova
author = {M R Faustova and E D Nikolskaya and M D Mollaev and A I Zabolotsky and O A Zhunina and M V Fomicheva and V I Schvets and A. V. Lobanov and N G Yabbarov and M B Sokol},
title = {Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-019-2690-1},
number = {12},
pages = {2216--2224},
doi = {10.1007/s11172-019-2690-1}
}
MLA
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Faustova, M. R., et al. “Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo.” Russian Chemical Bulletin, vol. 68, no. 12, Dec. 2019, pp. 2216-2224. https://doi.org/10.1007/s11172-019-2690-1.